Selective Killing of BRCA2-Deficient Ovarian Cancer Cells via MRE11 Blockade

Alblihy, Adel; Ali, Reem; Algethami, Mashael; Ritchie, Alison A.; Shoqafi, Ahmed; Alqahtani, Shatha; Mesquita, Katia A.; Toss, Michael S.; Ordóñez-Morán, Paloma; Jeyapalan, Jennie N.; Dekker, Lodewijk; Salerno, Martina; Grabowska, Anna M.; Rakha, Emad A.; Mongan, Nigel P.; Madhusudan, Srinivasan

doi:10.3390/ijms241310966

All Outputs (1)

Selective Killing of BRCA2-Deficient Ovarian Cancer Cells via MRE11 Blockade (2023)
Journal Article
Alblihy, A., Ali, R., Algethami, M., Ritchie, A. A., Shoqafi, A., Alqahtani, S., Mesquita, K. A., Toss, M. S., Ordóñez-Morán, P., Jeyapalan, J. N., Dekker, L., Salerno, M., Hartsuiker, E., Grabowska, A. M., Rakha, E. A., Mongan, N. P., & Madhusudan, S. (2023). Selective Killing of BRCA2-Deficient Ovarian Cancer Cells via MRE11 Blockade. International Journal of Molecular Sciences, 24(13), https://doi.org/10.3390/ijms241310966

The MRE11 nuclease is essential during DNA damage recognition, homologous recombination, and replication. BRCA2 plays important roles during homologous recombination and replication. Here, we show that effecting an MRE11 blockade using a prototypical... Read More about Selective Killing of BRCA2-Deficient Ovarian Cancer Cells via MRE11 Blockade.