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All Outputs (9)

Eczema Care Online behavioural interventions to support self-care for children and young people: two independent, pragmatic, randomised controlled trials (2022)
Journal Article
Santer, M., Muller, I., Becque, T., Stuart, B., Hooper, J., Steele, M., …Thomas, K. S. (2022). Eczema Care Online behavioural interventions to support self-care for children and young people: two independent, pragmatic, randomised controlled trials. BMJ, 379, Article e072007. https://doi.org/10.1136/bmj-2022-072007

Objective: To determine the effectiveness of two online behavioural interventions, one for parents and carers and one for young people, to support eczema self-management. Design: Two independent, pragmatic, parallel group, unmasked, randomised contro... Read More about Eczema Care Online behavioural interventions to support self-care for children and young people: two independent, pragmatic, randomised controlled trials.

'Eczema shouldn't control you; you should control eczema': qualitative process evaluation of online behavioural interventions to support young people and parents/carers of children with eczema (2022)
Journal Article
Greenwell, K., Sivyer, K., Howells, L., Steele, M., Ridd, M. J., Roberts, A., …Muller, I. (2023). 'Eczema shouldn't control you; you should control eczema': qualitative process evaluation of online behavioural interventions to support young people and parents/carers of children with eczema. British Journal of Dermatology, 188(4), 506-513. https://doi.org/10.1093/bjd/ljac115

Background There is a lack of well-conducted randomized controlled trials evaluating the effectiveness of theory-based online interventions for eczema. To address these deficiencies, we previously developed and demonstrated the effectiveness of two o... Read More about 'Eczema shouldn't control you; you should control eczema': qualitative process evaluation of online behavioural interventions to support young people and parents/carers of children with eczema.

Measuring Atopic Eczema Control and Itch Intensity in Clinical Practice: A Consensus Statement from the Harmonising Outcome Measures for Eczema in Clinical Practice (HOME-CP) Initiative (2022)
Journal Article
Leshem, Y. A., Chalmers, J. R., Apfelbacher, C., Katoh, N., Gerbens, L. A., Schmitt, J., …Simpson, E. L. (2022). Measuring Atopic Eczema Control and Itch Intensity in Clinical Practice: A Consensus Statement from the Harmonising Outcome Measures for Eczema in Clinical Practice (HOME-CP) Initiative. JAMA Dermatology, 158(12), 1429-1435. https://doi.org/10.1001/jamadermatol.2022.4211

Importance: Measuring outcomes in clinical practice can aid patient care, quality improvement, and real-world evidence generation. The Harmonising Outcome Measures for Eczema (HOME) Clinical Practice initiative is developing a list of validated, feas... Read More about Measuring Atopic Eczema Control and Itch Intensity in Clinical Practice: A Consensus Statement from the Harmonising Outcome Measures for Eczema in Clinical Practice (HOME-CP) Initiative.

Effectiveness and safety of lotion, cream, gel, and ointment emollients for childhood eczema: a pragmatic, randomised, phase 4, superiority trial (2022)
Journal Article
Ridd, M. J., Santer, M., MacNeill, S. J., Sanderson, E., Wells, S., Webb, D., …Thomas, K. S. (2022). Effectiveness and safety of lotion, cream, gel, and ointment emollients for childhood eczema: a pragmatic, randomised, phase 4, superiority trial. Lancet Child and Adolescent Health, 6(8), 522-532. https://doi.org/10.1016/S2352-4642%2822%2900146-8

Background: To our knowledge, there are no trials comparing emollients commonly used for childhood eczema. We aimed to compare the clinical effectiveness and safety of the four main emollient types: lotions, creams, gels, and ointments. Methods: We d... Read More about Effectiveness and safety of lotion, cream, gel, and ointment emollients for childhood eczema: a pragmatic, randomised, phase 4, superiority trial.

Using the Vitiligo Noticeability Scale in clinical trials: construct validity, interpretability, reliability and acceptability (2022)
Journal Article
Batchelor, J. M., Gran, S., Leighton, P., Howells, L., Montgomery, A. A., Tan, W., …Thomas, K. S. (2022). Using the Vitiligo Noticeability Scale in clinical trials: construct validity, interpretability, reliability and acceptability. British Journal of Dermatology, 187(4), 548-556. https://doi.org/10.1111/bjd.21671

Background: Validated outcome measures are needed for vitiligo trials. Objectives: To assess construct validity, interpretability, reliability and acceptability of the Vitiligo Noticeability Scale (VNS). Methods: We used images of vitiligo before and... Read More about Using the Vitiligo Noticeability Scale in clinical trials: construct validity, interpretability, reliability and acceptability.

Treatment of Hidradenitis Suppurativa Evaluation Study (THESEUS): protocol for a prospective cohort study (2022)
Journal Article
Bates, J., Stanton, H., Cannings-John, R., Thomas, K. S., Leighton, P., Howells, L. M., …Ingram, J. R. (2022). Treatment of Hidradenitis Suppurativa Evaluation Study (THESEUS): protocol for a prospective cohort study. BMJ Open, 12(4), Article e060815. https://doi.org/10.1136/bmjopen-2022-060815

Background Hidradenitis suppurativa (HS) is a chronic, painful, inflammatory skin disease with estimates of prevalence in the European population of 1%–2%. Despite being a relatively common condition, the evidence base for management of HS is limited... Read More about Treatment of Hidradenitis Suppurativa Evaluation Study (THESEUS): protocol for a prospective cohort study.

The HOME Core outcome set for clinical trials of atopic dermatitis (2022)
Journal Article
Williams, H. C., Schmitt, J., Thomas, K. S., Spuls, P. I., Simpson, E. L., Apfelbacher, C. J., …Boers, M. (2022). The HOME Core outcome set for clinical trials of atopic dermatitis. Journal of Allergy and Clinical Immunology, 149(6), 1899-1911. https://doi.org/10.1016/j.jaci.2022.03.017

Core outcome sets are critically important outcomes that should be measured in clinical trials. Their absence in atopic dermatitis is a form of research waste and impedes combining evidence to inform patient care. Here, we articulate the rationale fo... Read More about The HOME Core outcome set for clinical trials of atopic dermatitis.