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All Outputs (142)

Uncertainty about cellulitis and unmet patient information needs: a mixed methods study in primary and secondary care (2019)
Journal Article
Teasdale, E., Lalonde, A., Muller, I., Chalmers, J., Smart, P., Hooper, J., El-Gohary, M., Thomas, K. S., & Santer, M. (2019). Uncertainty about cellulitis and unmet patient information needs: a mixed methods study in primary and secondary care. British Journal of General Practice, 69(681), e279-e286. https://doi.org/10.3399/bjgp19X701873

Background: Cellulitis is a painful infection of the skin and underlying tissues, commonly affecting the lower leg: approximately a third of people experience recurrence. Patients’ ability to recover from cellulitis or prevent recurrence is likely to... Read More about Uncertainty about cellulitis and unmet patient information needs: a mixed methods study in primary and secondary care.

Navigating the landscape of core outcome set development in dermatology (2019)
Journal Article
Prinsen, C. A., Spuls, P. I., Kottner, J., Thomas, K. S., Apfelbacher, C., Chalmers, J. R., Deckert, S., Furue, M., Gerbens, L., Kirkham, J., Simpson, E. L., Alam, M., Balzer, K., Beeckman, D., Eleftheriadou, V., Ezzedine, K., Horbach, S. E., Ingram, J. R., Layton, A. M., Weller, K., …Schmitt, J. (2019). Navigating the landscape of core outcome set development in dermatology. Journal of The American Academy of Dermatology, 81(1), 297-305. https://doi.org/10.1016/j.jaad.2019.03.009

© 2019 American Academy of Dermatology, Inc. The development of core outcome sets (COSs; ie, a minimum set of core outcomes that should be measured and reported in all trials or in clinical practice for a specific condition) in dermatology is increas... Read More about Navigating the landscape of core outcome set development in dermatology.

A systematic review showing the lack of diagnostic criteria and tools developed for lower limb cellulitis (2019)
Journal Article
Patel, M., Lee, S. I., Akyea, R. K., Grindlay, D., Francis, N., Levell, N. J., Smart, P., Kai, J., & Thomas, K. (2019). A systematic review showing the lack of diagnostic criteria and tools developed for lower limb cellulitis. British Journal of Dermatology, 181(6), 1156-1165. https://doi.org/10.1111/bjd.17857

Background: Cellulitis can be a difficult diagnosis to make. 31% of patients admitted from the emergency department with suspected lower limb cellulitis are misdiagnoses, with incorrect treatment potentially resulting in avoidable hospital admission... Read More about A systematic review showing the lack of diagnostic criteria and tools developed for lower limb cellulitis.

Defining and measuring " eczema control " : an international qualitative study to explore the views of those living with and treating atopic eczema (2019)
Journal Article
Howells, L., Thomas, K. S., Sears, A. V., Nasr, I., Wollenberg, A., Schuttelaar, M. L., Romeijn, G. L., Paller, A. S., Mueller, K., Doytcheva, K., Kataoka, Y., Daguze, J., Barbarot, S., Von Kobyletzki, L. B., Beckman, L., Ratib, S., Cowdell, F., Santer, M., & Chalmers, J. R. (2019). Defining and measuring " eczema control " : an international qualitative study to explore the views of those living with and treating atopic eczema. Journal of the European Academy of Dermatology and Venereology, 33(6), 1124-1132. https://doi.org/10.1111/jdv.15475

Background: Atopic eczema (also known as eczema) is a chronic, inflammatory skin condition that often afflicts patients’ health and wellbeing. The Harmonising Outcome Measures for Eczema (HOME) initiative recommends that “long-term control of eczema”... Read More about Defining and measuring " eczema control " : an international qualitative study to explore the views of those living with and treating atopic eczema.

What's new in atopic eczema? An analysis of systematic reviews published in 2016. Part 2: Epidemiology, aetiology and risk factors (2019)
Journal Article
Lloyd-Lavery, A., Solman, L., Grindlay, D. J. C., Rogers, N. K., Thomas, K. S., & Harman, K. E. (2019). What's new in atopic eczema? An analysis of systematic reviews published in 2016. Part 2: Epidemiology, aetiology and risk factors. Clinical and Experimental Dermatology, 44(4), 370-375. https://doi.org/10.1111/ced.13853

© 2019 British Association of Dermatologists This review forms part of a series of annual updates that summarize the evidence base for atopic eczema (AE), providing a succinct guide for clinicians and patients. It presents the key findings from 14 sy... Read More about What's new in atopic eczema? An analysis of systematic reviews published in 2016. Part 2: Epidemiology, aetiology and risk factors.

What's new in atopic eczema? An analysis of systematic reviews published in 2016. Part 1: treatment and prevention (2019)
Journal Article
Solman, L., Lloyd-Lavery, A., Grindlay, D. J. C., Rogers, N. K., Thomas, K. S., & Harman, K. E. (2019). What's new in atopic eczema? An analysis of systematic reviews published in 2016. Part 1: treatment and prevention. Clinical and Experimental Dermatology, 44(4), 363-369. https://doi.org/10.1111/ced.13885

© 2019 British Association of Dermatologists This review is part of a series of annual updates summarizing the evidence base for atopic eczema (AE). It provides a summary of key findings from 28 systematic reviews that were published or indexed durin... Read More about What's new in atopic eczema? An analysis of systematic reviews published in 2016. Part 1: treatment and prevention.

What's new in atopic eczema? An analysis of systematic reviews published in 2016. Part 3: nomenclature and outcome assessment (2019)
Journal Article
Lloyd-Lavery, A., Solman, L., Grindlay, D. J. C., Rogers, N. K., Thomas, K. S., & Harman, K. E. (2019). What's new in atopic eczema? An analysis of systematic reviews published in 2016. Part 3: nomenclature and outcome assessment. Clinical and Experimental Dermatology, 44(4), 376-380. https://doi.org/10.1111/ced.13886

© 2019 British Association of Dermatologists This review forms part of a series of annual updates that summarize the evidence base for atopic eczema (AE). It presents the key findings from 11 systematic reviews published in 2016 that focus on AE outc... Read More about What's new in atopic eczema? An analysis of systematic reviews published in 2016. Part 3: nomenclature and outcome assessment.

Future research priorities for lichen sclerosus – results of a James Lind Alliance Priority Setting Partnership (2019)
Journal Article
Simpson, R., Cooper, S., Kirtschig, G., Larsen, S., Lawton, S., McPhee, M., Murphy, R., Nunns, D., Rees, S., Tarpey, M., Thomas, K., & Lichen Sclerosus Priority Setting Partnership Steering Group. (2019). Future research priorities for lichen sclerosus – results of a James Lind Alliance Priority Setting Partnership. British Journal of Dermatology, 180(5), 1236-1237. https://doi.org/10.1111/bjd.17447

Patients’ understanding of cellulitis and views about how best to prevent recurrent episodes: mixed-methods study in primary and secondary care (2018)
Journal Article
Teasdale, E. J., Lalonde, A., Muller, I., Chalmers, J., Smart, P., Hooper, J., El-Gohary, M., Thomas, K. S., & Santer, M. (2019). Patients’ understanding of cellulitis and views about how best to prevent recurrent episodes: mixed-methods study in primary and secondary care. British Journal of Dermatology, 180(4), 810-820. https://doi.org/10.1111/bjd.17445

Background: Cellulitis is a common painful infection of the skin and underlying tissues that recurs in approximately one-third of cases. The only proven strategy to reduce the risk of recurrence is long-term, low-dose antibiotics. Given current conce... Read More about Patients’ understanding of cellulitis and views about how best to prevent recurrent episodes: mixed-methods study in primary and secondary care.

The red leg dilemma: a scoping review of the challenges of diagnosing lower limb cellulitis (2018)
Journal Article
Patel, M., Kai, J., Lee, S., & Thomas, K. (2019). The red leg dilemma: a scoping review of the challenges of diagnosing lower limb cellulitis. British Journal of Dermatology, 180(5), 993-1000. https://doi.org/10.1111/bjd.17415

Background: Suspected lower limb cellulitis presentations are commonly misdiagnoses, resulting in avoidable antibiotic prescribing or hospital admissions. Understanding the challenges posed in diagnosing cellulitis may help enhance future care.

Ob... Read More about The red leg dilemma: a scoping review of the challenges of diagnosing lower limb cellulitis.

Adding emollient bath additives to standard eczema management for children with eczema: the BATHE RCT (2018)
Journal Article
Santer, M., Rumsby, K., Ridd, M. J., Francis, N. A., Stuart, B., Chorozoglou, M., Roberts, A., Liddiard, L., Nollett, C., Hooper, J., Prude, M., Wood, W., Thomas-Jones, E., Becque, T., Thomas, K. S., Williams, H. C., & Little, P. (2018). Adding emollient bath additives to standard eczema management for children with eczema: the BATHE RCT. Health Technology Assessment, 22(57), 1-116. https://doi.org/10.3310/hta22570

Plain English Summary
Eczema is very common in children and can have a significant impact, causing itching and sleep problems. The main treatments are emollients, which are used to moisturise the skin, and steroid creams or ointments to treat flare-... Read More about Adding emollient bath additives to standard eczema management for children with eczema: the BATHE RCT.

Feasibility of weekly participant‐reported data collection in a pragmatic randomised controlled trial in primary care: experiences from the BATHE trial (Bath Additives for the Treatment of cHildhood Eczema) (2018)
Journal Article
Stuart, B., Rumsby, K., Santer, M., Ridd, M. J., Francis, N. A., Chorozoglou, M., Spreadbury, C., Steele, M., Nollett, C., Liddiard, L., Prude, M., Hooper, J., Thomas‐Jones, E., Roberts, A., Thomas, K. S., Williams, H. C., & Little, P. (2018). Feasibility of weekly participant‐reported data collection in a pragmatic randomised controlled trial in primary care: experiences from the BATHE trial (Bath Additives for the Treatment of cHildhood Eczema). Trials, 19, Article 582. https://doi.org/10.1186/s13063-018-2962-3

Background: Patient‐reported outcomes measures in clinical trials ensure that evaluations of effectiveness focus on outcomes that are important to patients. In relapsing‐remitting conditions such as eczema, repeated measurements may allow a more accu... Read More about Feasibility of weekly participant‐reported data collection in a pragmatic randomised controlled trial in primary care: experiences from the BATHE trial (Bath Additives for the Treatment of cHildhood Eczema).

Development of a standardised set of metrics for monitoring site performance in multicentre randomised trials: a Delphi study (2018)
Journal Article
Whitham, D., Turzanski, J., Bradshaw, L., Clarke, M., Culliford, L., Duley, L., Shaw, L., Skea, Z., Treweek, S. P., Walker, K., Williamson, P. R., Montgomery, A. A., Bevan, S., Devall, A., Fairbrother, K., Goodman, K., Hewitt, C., Hobson, R., Lawton, S., Lock, S., …Wood, J. (2018). Development of a standardised set of metrics for monitoring site performance in multicentre randomised trials: a Delphi study. Trials, 19, Article 557. https://doi.org/10.1186/s13063-018-2940-9

Background
Site performance is key to the success of large multicentre randomised trials. A standardised set of clear and accessible summaries of site performance could facilitate the timely identification and resolution of potential problems, minim... Read More about Development of a standardised set of metrics for monitoring site performance in multicentre randomised trials: a Delphi study.

Help for Future Research: Lessons Learned in Trial Design, Recruitment, and Delivery From the “hELP” Study (2018)
Journal Article
Simpson, R. C., Murphy, R., Bratton, D. J., Sydes, M. R., Wilkes, S., Nankervis, H., Dowey, S., Bell, H., Cruickshank, M. E., Gibbon, K., Green, C. M., Wong, C., Owen, C. M., London, K., Haque, S., & Thomas, K. S. (2018). Help for Future Research: Lessons Learned in Trial Design, Recruitment, and Delivery From the “hELP” Study. Journal of Lower Genital Tract Disease, 22(4), 405-408. https://doi.org/10.1097/LGT.0000000000000407

What's new in atopic eczema? An analysis of systematic reviews published in 2015. Part 2: prevention and treatment (2018)
Journal Article
Lloyd-Lavery, A., Rogers, N. K., Davies, E., Grindlay, D. J. C., & Thomas, K. S. (2018). What's new in atopic eczema? An analysis of systematic reviews published in 2015. Part 2: prevention and treatment. Clinical and Experimental Dermatology, 43(6), 653-658. https://doi.org/10.1111/ced.13554

This review forms part of a series of annual updates that summarize the evidence base for atopic eczema (AE), providing a succinct guide for clinicians and patients. It provides a summary of key findings from 26 systematic reviews that were published... Read More about What's new in atopic eczema? An analysis of systematic reviews published in 2015. Part 2: prevention and treatment.

Standardized reporting of the Eczema Area and Severity Index (EASI) and the Patient-Oriented Eczema Measure (POEM): a recommendation by the Harmonising Outcome Measures for Eczema (HOME) Initiative (2018)
Journal Article
Grinich, E. E., Schmitt, J., Küster, D., Spuls, P. I., Williams, H. C., Chalmers, J. R., Thomas, K. S., Apfelbacher, C., Prinsen, C. A., Furue, M., Stuart, B., Carter, B., & Simpson, E. L. (2018). Standardized reporting of the Eczema Area and Severity Index (EASI) and the Patient-Oriented Eczema Measure (POEM): a recommendation by the Harmonising Outcome Measures for Eczema (HOME) Initiative. British Journal of Dermatology, 179(2), 540-541. https://doi.org/10.1111/bjd.16732

Emollient bath additives for the treatment of childhood eczema (BATHE): multi-centre pragmatic parallel group randomised controlled trial of clinical and cost-effectiveness (2018)
Journal Article
Santer, M., Ridd, M. J., Francis, N. A., Stuart, B., Rumsby, K., Chorozoglou, M., Becque, T., Roberts, A., Liddiard, L., Nollett, C., Hooper, J., Prude, M., Wood, W., Thomas, K. S., Thomas-Jones, E., Williams, H. C., & Little, P. (2018). Emollient bath additives for the treatment of childhood eczema (BATHE): multi-centre pragmatic parallel group randomised controlled trial of clinical and cost-effectiveness. BMJ, 361, 1-8. https://doi.org/10.1136/bmj.k1332

Objectives: To determine the clinical and cost-effectiveness of including emollient bath additives in the management of childhood eczema.
Trial design: Pragmatic randomised open-label superiority trial with two parallel groups.
Setting and recrui... Read More about Emollient bath additives for the treatment of childhood eczema (BATHE): multi-centre pragmatic parallel group randomised controlled trial of clinical and cost-effectiveness.

Report from the fifth international consensus meeting to harmonize core outcome measures for atopic eczema/dermatitis clinical trials (HOME initiative) (2018)
Journal Article
Chalmers, J., Thomas, K., Apfelbacher, C., Williams, H., Prinsen, C., Spuls, P., Simpson, E., Gerbens, L., Boers, M., Barbarot, S., Stalder, J., Abuabara, K., Aoki, V., Ardeleanu, M., Armstrong, J., Bang, B., Berents, T., Burton, T., Butler, L., Chubachi, T., …Zaniboni, M. (2018). Report from the fifth international consensus meeting to harmonize core outcome measures for atopic eczema/dermatitis clinical trials (HOME initiative). British Journal of Dermatology, 178(5), e332-e341. https://doi.org/10.1111/bjd.16543

This is the report from the fifth meeting of the Harmonising Outcome Measures for Eczema initiative (HOME V). The meeting was held on 12–14 June 2017 in Nantes, France, with 81 participants. The main aims of the meeting were (i) to achieve consensus... Read More about Report from the fifth international consensus meeting to harmonize core outcome measures for atopic eczema/dermatitis clinical trials (HOME initiative).

Home interventions and light therapy for treatment of vitiligo (HI-Light Vitiligo Trial): study protocol for a randomized controlled trial (2018)
Journal Article
Haines, R. H., Thomas, K. S., Montgomery, A. A., Ravenscroft, J. C., Akram, P., Chalmers, J., Whitman, D., Duley, L., Eleftheriadou, V., Meakin, G., Mitchell, E., White, J., Rogers, A., Sach, T., Santer, M., Tan, W., Hepburn, T., Williams, H. C., & Batchelor, J. M. (2018). Home interventions and light therapy for treatment of vitiligo (HI-Light Vitiligo Trial): study protocol for a randomized controlled trial. BMJ Open, 8(4), Article e018649. https://doi.org/10.1136/bmjopen-2017-018649

Vitiligo is a condition resulting in white patches on the skin. People with vitiligo can suffer from low self-esteem, psychological disturbance and diminished quality of life. Vitiligo is often poorly managed, partly due to lack of high quality evide... Read More about Home interventions and light therapy for treatment of vitiligo (HI-Light Vitiligo Trial): study protocol for a randomized controlled trial.