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All Outputs (21)

Ethical challenges experienced by veterinary practitioners in relation to adverse events: Insights from a qualitative study (2023)
Journal Article
Gibson, J., Brennan, M. L., Oxtoby, C., Mossop, L., & White, K. (2023). Ethical challenges experienced by veterinary practitioners in relation to adverse events: Insights from a qualitative study. Veterinary Record, 193(12), Article e3601. https://doi.org/10.1002/vetr.3601

Background
Understanding ethical challenges experienced in relation to adverse events is necessary to inform strategies that optimise patient safety and practitioner wellbeing.

Methods
A qualitative exploration of UK veterinary practitioners’ ex... Read More about Ethical challenges experienced by veterinary practitioners in relation to adverse events: Insights from a qualitative study.

Robenacoxib versus meloxicam following ovariohysterectomy in cats: A randomised, prospective clinical trial involving owner‐based assessment of pain (2023)
Journal Article
Hillen, F., Polson, S., Yates, D., Watkinson, R., & White, K. (in press). Robenacoxib versus meloxicam following ovariohysterectomy in cats: A randomised, prospective clinical trial involving owner‐based assessment of pain. Veterinary Record, Article e3264. https://doi.org/10.1002/vetr.3264

Background
Injectable non-steroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed to queens undergoing ovariohysterectomy (OVH), but the requirement for postoperative administration is unclear and practices vary. Existing studies assessin... Read More about Robenacoxib versus meloxicam following ovariohysterectomy in cats: A randomised, prospective clinical trial involving owner‐based assessment of pain.

Alfaxalone population pharmacokinetics in the rat: Model application for pharmacokinetic and pharmacodynamic design in inbred and outbred strains and sexes (2022)
Journal Article
White, K., Aldurdunji, M., Harris, J., Ortori, C., & Paine, S. (2022). Alfaxalone population pharmacokinetics in the rat: Model application for pharmacokinetic and pharmacodynamic design in inbred and outbred strains and sexes. Pharmacology Research and Perspectives, 10(6), Article e01031. https://doi.org/10.1002/prp2.1031

The translation of new injectable anaesthetic drugs from rodent to humans remains slow, despite the realisation that reliance on the volatile agents is unsustainable from an environmental perspective. The aim of this study was to investigate the infl... Read More about Alfaxalone population pharmacokinetics in the rat: Model application for pharmacokinetic and pharmacodynamic design in inbred and outbred strains and sexes.

Vitamin D status in chimpanzees in human care: a Europe wide study (2022)
Journal Article
Moittié, S., Jarvis, R., Bandelow, S., Byrne, S., Dobbs, P., Grant, M., …Baiker, K. (2022). Vitamin D status in chimpanzees in human care: a Europe wide study. Scientific Reports, 12, Article 17625. https://doi.org/10.1038/s41598-022-21211-6

While vitamin D deficiency is a public health concern in humans, comparatively little is known about vitamin D levels in non-human primates. Vitamin D plays a crucial role in overall health and its deficiency is associated with a range of disorders,... Read More about Vitamin D status in chimpanzees in human care: a Europe wide study.

“We’re gonna end up scared to do anything”: a qualitative exploration of how complaints are experienced by UK veterinary practitioners (2022)
Journal Article
Gibson, J., White, K., Mossop, L., Oxtoby, C., & Brennan, M. (2022). “We’re gonna end up scared to do anything”: a qualitative exploration of how complaints are experienced by UK veterinary practitioners. Veterinary Record, 191(4), Article e1737. https://doi.org/10.1002/vetr.1737

Background: UK veterinary practitioners are reported to be fearful of client complaints but their experiences have not been formally captured. Understanding how complaints impact veterinary practitioners is key to mitigating detrimental consequences.... Read More about “We’re gonna end up scared to do anything”: a qualitative exploration of how complaints are experienced by UK veterinary practitioners.

Sevoflurane or isoflurane anaesthesia? A prospective, randomised blinded clinical trial in horses undergoing elective surgery (2021)
Journal Article
White, K. L., Hird, J. F. R., & Taylor, P. M. (2021). Sevoflurane or isoflurane anaesthesia? A prospective, randomised blinded clinical trial in horses undergoing elective surgery. Veterinary Record, 189(3), Article e507. https://doi.org/10.1002/vetr.507

Background: Isoflurane is the only volatile anaesthetic agent licensed for equine use in the United Kingdom, but sevoflurane is also commonly used. The two agents have rarely been compared for use in clinical elective surgery. Methods: This single ce... Read More about Sevoflurane or isoflurane anaesthesia? A prospective, randomised blinded clinical trial in horses undergoing elective surgery.

Evaluation of the agreement of two oscillometric blood pressure devices with invasive blood pressure in anaesthetized chimpanzees (Pan troglodytes) (2021)
Journal Article
Moittié, S., Dobbs, P., Redrobe, S., Liptovszky, M., & White, K. (2021). Evaluation of the agreement of two oscillometric blood pressure devices with invasive blood pressure in anaesthetized chimpanzees (Pan troglodytes). Veterinary Anaesthesia and Analgesia, 48(5), 688-696. https://doi.org/10.1016/j.vaa.2021.01.010

Objective: To evaluate the agreement of two noninvasive blood pressure devices: a human device with the cuff placed on the wrist (Omron R1) and a veterinary device with the cuff placed on the upper brachium (Surgivet Advisor Vital Signs Monitor) with... Read More about Evaluation of the agreement of two oscillometric blood pressure devices with invasive blood pressure in anaesthetized chimpanzees (Pan troglodytes).

Assessing the Educational Value of a Zoo Placement for Veterinary Students: A Report on Student Feedback and Perceptions (2021)
Journal Article
Liptovszky, M., Dobbs, P., Moittie, S., White, K., Targett, M., & Strong, V. (2022). Assessing the Educational Value of a Zoo Placement for Veterinary Students: A Report on Student Feedback and Perceptions. Journal of Veterinary Medical Education, 49(2), 236-240. https://doi.org/10.3138/jvme-2020-0064

Zoological medicine is an expanding field with limited practical training opportunities for veterinary students. Those training programs that do exist require significant financial and resource investment by both veterinary schools and the zoological... Read More about Assessing the Educational Value of a Zoo Placement for Veterinary Students: A Report on Student Feedback and Perceptions.

Comparison of 25‐hydroxyvitamin D concentration in chimpanzee dried blood spots and serum (2020)
Journal Article
Moittié, S., Graham, P. A., Barlow, N., Dobbs, P., Liptovszky, M., Redrobe, S., & White, K. (2020). Comparison of 25‐hydroxyvitamin D concentration in chimpanzee dried blood spots and serum. Veterinary Clinical Pathology, 49(2), 299-306. https://doi.org/10.1111/vcp.12863

Background
Dried blood spots (DBS) are used in human medicine to measure total 25‐hydroxyvitamin D (25‐OHD) in the blood. However, this easy and affordable sampling technique has not been evaluated in primates to measure vitamin D concentrations.... Read More about Comparison of 25‐hydroxyvitamin D concentration in chimpanzee dried blood spots and serum.

Comparison of the effects of buprenorphine and methadone in combination with medetomidine followed by intramuscular alfaxalone for anaesthesia of cats undergoing ovariohysterectomy (2019)
Journal Article
Mahdmina, A., Evans, A., Yates, D., & White, K. L. (2019). Comparison of the effects of buprenorphine and methadone in combination with medetomidine followed by intramuscular alfaxalone for anaesthesia of cats undergoing ovariohysterectomy. Journal of Feline Medicine and Surgery, https://doi.org/10.1177/1098612x19826357

Objectives

The aim of this study was to compare quality of anaesthesia and analgesia between methadone and buprenorphine in combination with medetomidine after induction with intramuscular (IM) alfaxalone in cats undergoing ovariohysterectomy.... Read More about Comparison of the effects of buprenorphine and methadone in combination with medetomidine followed by intramuscular alfaxalone for anaesthesia of cats undergoing ovariohysterectomy.

A clinical study to evaluate the cardiopulmonary characteristics of two different anaesthetic protocols (tiletamine/zolazepam +/- medetomidine) and to evaluate their suitability for the immobilisation of healthy chimpanzees (2018)
Journal Article
Strong, V., Möller, T., Tillman, A.-S., Träff, S., Guevara, L., Martin, M., …White, K. (2018). A clinical study to evaluate the cardiopulmonary characteristics of two different anaesthetic protocols (tiletamine/zolazepam +/- medetomidine) and to evaluate their suitability for the immobilisation of healthy chimpanzees. Veterinary Anaesthesia and Analgesia, https://doi.org/10.1016/j.vaa.2018.06.015

Objective: To characterise the cardiopulmonary characteristics of two different anaesthetic protocols (tiletamine/zolazepam +/- medetomidine) and their suitability for the immobilisation of healthy chimpanzees undergoing cardiac assessment.
Study de... Read More about A clinical study to evaluate the cardiopulmonary characteristics of two different anaesthetic protocols (tiletamine/zolazepam +/- medetomidine) and to evaluate their suitability for the immobilisation of healthy chimpanzees.

A retrospective review of great ape cardiovascular disease epidemiology and pathology (2018)
Journal Article
Strong, V. J., Martin, M., Redrobe, S., White, K., & Baiker, K. (2018). A retrospective review of great ape cardiovascular disease epidemiology and pathology. International Zoo Yearbook, 52(1), 113-125. https://doi.org/10.1111/izy.12193

Cardiovascular disease is associated with significant mortality in zoo-housed great apes and yet little is know about its epidemiology and aetiopathogenesis, and therefore its diagnosis, treatment and prevention. In this retrospective study, the fre... Read More about A retrospective review of great ape cardiovascular disease epidemiology and pathology.

Gainfully employing descending controls in acute and chronic pain management (2018)
Journal Article
White, K., Targett, M., & Harris, J. (2018). Gainfully employing descending controls in acute and chronic pain management. Veterinary Journal, 237, 16-25. https://doi.org/10.1016/j.tvjl.2018.05.005

Specific primary afferent fibres termed nociceptors are responsible for transmitting nociceptive information. Centrally the axonal terminals of these fibres synapse with secondary projection neurones in the spinal dorsal horn to transmit nociceptive... Read More about Gainfully employing descending controls in acute and chronic pain management.

Clinical comparison of alfaxalone, ketamine and propofol following medetomidine and methadone in dogs (2017)
Journal Article
White, K. L., & Yates, D. (in press). Clinical comparison of alfaxalone, ketamine and propofol following medetomidine and methadone in dogs. Veterinary Anaesthesia and Analgesia, https://doi.org/10.1016/j.vaa.2016.12.057

Objective

To compare the clinical effects of alfaxalone, ketamine and propofol in dogs following premedication with medetomidine and methadone.

Study design

Prospective, ‘blinded’ and randomized clinical study.

Animals

A total of 75 ma... Read More about Clinical comparison of alfaxalone, ketamine and propofol following medetomidine and methadone in dogs.

A clinical evaluation of the pharmacokinetics and pharmacodynamics of intravenous alfaxalone in cyclodextrin in male and female rats following a loading dose and constant rate infusion (2017)
Journal Article
White, K. L., Paine, S., & Harris, J. (2017). A clinical evaluation of the pharmacokinetics and pharmacodynamics of intravenous alfaxalone in cyclodextrin in male and female rats following a loading dose and constant rate infusion. Veterinary Anaesthesia and Analgesia, 44(4), https://doi.org/10.1016/j.vaa.2017.01.001

Objective: To characterise, as a clinical study, the pharmacokinetics and pharmacodynamics and describe the hypnotic effect of the neurosteroid alfaxalone (3α-hydroxy-5 α-pregnane-11, 20-dione) formulated with 2-hydroxypropyl-β-cyclodextrin in male a... Read More about A clinical evaluation of the pharmacokinetics and pharmacodynamics of intravenous alfaxalone in cyclodextrin in male and female rats following a loading dose and constant rate infusion.

A systematic review of the literature relating to captive great ape morbidity and mortality (2016)
Journal Article
Strong, V. J., Grindlay, D. J., Redrobe, S., Cobb, M., & White, K. (2016). A systematic review of the literature relating to captive great ape morbidity and mortality. Journal of Zoo and Wildlife Medicine, 47(3), https://doi.org/10.1638/2015-0240.1

Wild bonobos (Pan paniscus), chimpanzees (Pan troglodytes), Western gorillas (Gorilla gorilla), and orangutans (Pongo pygmaeus, Pongo abelii) are threatened with extinction. In order to help maintain a self-sustaining zoo population, clinicians requi... Read More about A systematic review of the literature relating to captive great ape morbidity and mortality.

Assessment of acute pain in cats: signs, tools and limitations (2016)
Journal Article
L White, K. (2017). Assessment of acute pain in cats: signs, tools and limitations. Companion Animal, 21(8), 458-465. https://doi.org/10.12968/coan.2016.21.8.458

Recent advances in pain assessment in companion animals represent a tenacious, painstaking and time-consuming dedication to improving animal welfare. Attitudes and knowledge about pain assessment, particularly in cats, have changed dramatically in th... Read More about Assessment of acute pain in cats: signs, tools and limitations.

We need to talk about error: causes and types of error in veterinary practice (2015)
Journal Article
Oxtoby, C., Ferguson, E., White, K., & Mossop, L. (2015). We need to talk about error: causes and types of error in veterinary practice. Veterinary Record, 177(17), https://doi.org/10.1136/vr.103331

Patient safety research in human medicine has identified the causes and common types of medical error and subsequently informed the development of interventions which mitigate harm, such as the WHO’s safe surgery checklist. There is no such evidence... Read More about We need to talk about error: causes and types of error in veterinary practice.