All Outputs (87)

A dose- rather than delivery profile-dependent mechanism regulates the "muscle-full" effect in response to oral essential amino acid intake in young men (2014)
Journal Article
Mitchell, W. K., Phillips, B. E., Williams, J. P., Rankin, D., Lund, J. N., Smith, K., & Atherton, P. J. (2015). A dose- rather than delivery profile-dependent mechanism regulates the "muscle-full" effect in response to oral essential amino acid intake in young men. Journal of Nutrition, 145(2), https://doi.org/10.3945/jn.114.199604

Background: The anabolic response of skeletal muscle to essential amino acids (EAAs) is dose dependent, maximal at modest doses, and short lived, even with continued EAA availability, a phenomenon termed “muscle-full.” However, the effect of EAA inge... Read More about A dose- rather than delivery profile-dependent mechanism regulates the "muscle-full" effect in response to oral essential amino acid intake in young men.

An evaluation of POSSUM and P-POSSUM scoring in predicting post-operative mortality in a level 1 critical care setting (2014)
Journal Article
Scott, S., Lund, J. N., Gold, S., Elliott, R., Vater, M., Chakrabarty, M. P., Heinink, T. P., & Williams, J. P. (2014). An evaluation of POSSUM and P-POSSUM scoring in predicting post-operative mortality in a level 1 critical care setting. BMC Anesthesiology, 14(1), Article 104. https://doi.org/10.1186/1471-2253-14-104

Background

POSSUM and P-POSSUM are used in the assessment of outcomes in surgical patients. Neither scoring systems’ accuracy has been established where a level 1 critical care facility (level 1 care ward) is available for perioperative care. We c... Read More about An evaluation of POSSUM and P-POSSUM scoring in predicting post-operative mortality in a level 1 critical care setting.

One-third of patients fail to return to work 1 year after surgery for colorectal cancer (2014)
Journal Article
Bhalla, A., Williams, J. P., Hurst, N., Speake, W., Tierney, G., Tou, S., & Lund, J. N. (2014). One-third of patients fail to return to work 1 year after surgery for colorectal cancer. Techniques in Coloproctology, 18(12), https://doi.org/10.1007/s10151-014-1232-y

Background

Achieving full recovery after colorectal cancer surgery means a return to normal physical and psychological health and to a normal social life. Recovery data focusses on time to discharge rather than longer term functionality including... Read More about One-third of patients fail to return to work 1 year after surgery for colorectal cancer.

Effect of 3 to 5 years of scheduled CEA and CT follow-upto detect recurrence of colorectal cancer The FACS Randomized Clinical Trial (2014)
Journal Article
Primrose, J. N., Perera, R., Gray, A., Rose, P., Fuller, A., Corkhill, A., George, S., Mant, D., & FACS Trial Investigators. (2014). Effect of 3 to 5 years of scheduled CEA and CT follow-upto detect recurrence of colorectal cancer The FACS Randomized Clinical Trial. Journal of the American Medical Association, 311(3), https://doi.org/10.1001/jama.2013.285718

IMPORTANCE Intensive follow-up after surgery for colorectal cancer is common practice but is based on limited evidence.
OBJECTIVE To assess the effect of scheduled blood measurement of carcinoembryonic antigen (CEA) and computed tomography (CT) as f... Read More about Effect of 3 to 5 years of scheduled CEA and CT follow-upto detect recurrence of colorectal cancer The FACS Randomized Clinical Trial.

Effect of tumor burden and subsequent surgical resection on skeletal muscle mass and protein turnover in colorectal cancer patients (2012)
Journal Article
Williams, J. P., Phillips, B. E., Smith, K., Atherton, P. J., Rankin, D., Selby, A. L., Liptrot, S., Lund, J., Larvin, M., & Rennie, M. J. (2012). Effect of tumor burden and subsequent surgical resection on skeletal muscle mass and protein turnover in colorectal cancer patients. American Journal of Clinical Nutrition, 96(5), 1064-1070. https://doi.org/10.3945/ajcn.112.045708

Effect of colon cancer and surgical resection on skeletal muscle mitochondrial enzyme activity in colon cancer patients: a pilot study (2012)
Journal Article
Phillips, B. E., Smith, K., Liptrot, S., Atherton, P. J., Varadhan, K., Rennie, M. J., Larvin, M., Lund, J. N., & Williams, J. P. (2013). Effect of colon cancer and surgical resection on skeletal muscle mitochondrial enzyme activity in colon cancer patients: a pilot study. Journal of Cachexia, Sarcopenia and Muscle, 4(1), 71-77. https://doi.org/10.1007/s13539-012-0073-7

Expression of a large LINE-1-driven antisense RNA is linked to epigenetic silencing of the metastasis suppressor gene TFPI-2 in cancer
Journal Article
Cruickshanks, H., Vafadar-Isfahani, N., Dunican, D., Lee, A., Sproul, D., Lund, J. N., Meehan, R., & Tufarelli, C. Expression of a large LINE-1-driven antisense RNA is linked to epigenetic silencing of the metastasis suppressor gene TFPI-2 in cancer. Nucleic Acids Research, 41(14), https://doi.org/10.1093/nar/gkt438

LINE-1 retrotransposons are abundant repetitive
elements of viral origin, which in normal cells are
kept quiescent through epigenetic mechanisms.
Activation of LINE-1 occurs frequently in cancer
and can enable LINE-1 mobilization but also has
re... Read More about Expression of a large LINE-1-driven antisense RNA is linked to epigenetic silencing of the metastasis suppressor gene TFPI-2 in cancer.