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The effect of influenza virus on the human oropharyngeal microbiome (2018)
Journal Article
Ramos-Sevillano, E., Wade, W. G., Mann, A., Gilbert, A., Lambkin-Williams, R., Killingley, B., …Tang, C. M. (2019). The effect of influenza virus on the human oropharyngeal microbiome. Clinical Infectious Diseases, 68(12), 1993-2002. https://doi.org/10.1093/cid/ciy821

© The Author(s) 2018. Background. Secondary bacterial infections are an important cause of morbidity and mortality associated with influenza infections. As bacterial disease can be caused by a disturbance of the host microbiome, we examined the impac... Read More about The effect of influenza virus on the human oropharyngeal microbiome.

Clinicians' attitude towards a placebo-controlled randomised clinical trial investigating the effect of neuraminidase inhibitors in adults hospitalised with influenza (2018)
Journal Article
Bradbury, N., Nguyen-Van-Tam, J. S., & Lim, W. S. (2018). Clinicians' attitude towards a placebo-controlled randomised clinical trial investigating the effect of neuraminidase inhibitors in adults hospitalised with influenza. BMC Health Services Research, 18, 1-9. https://doi.org/10.1186/s12913-018-3122-x

Background: The value of neuraminidase inhibitors (NAIs) in reducing severe clinical outcomes from influenza is debated. A clinical trial to generate better evidence is desirable. However, it is unknown whether UK clinicians would support a placebo c... Read More about Clinicians' attitude towards a placebo-controlled randomised clinical trial investigating the effect of neuraminidase inhibitors in adults hospitalised with influenza.

Five years of monitoring for the emergence of oseltamivir resistance in patients with influenza A infections in the Influenza Resistance Information Study (IRIS) (2018)
Journal Article
Lina, B., Boucher, C., Osterhaus, A., Monto, A. S., Schutten, M., Whitley, R. J., & Nguyen-Van-Tam, J. S. (2018). Five years of monitoring for the emergence of oseltamivir resistance in patients with influenza A infections in the Influenza Resistance Information Study (IRIS). Influenza and Other Respiratory Viruses, 12(2), 267-278. https://doi.org/10.1111/irv.12534

Effects of seasonal and pandemic influenza on health-related quality of life, work and school absence in England: Results from the Flu Watch cohort study (2017)
Journal Article
Fragaszy, E. B., Warren-Gash, C., White, P. J., Zambon, M., Edmunds, W. J., Nguyen-Van-Tam, J. S., & Hayward, A. C. (2018). Effects of seasonal and pandemic influenza on health-related quality of life, work and school absence in England: Results from the Flu Watch cohort study. Influenza and Other Respiratory Viruses, 12(1), 171-182. https://doi.org/10.1111/irv.12506

Background: Estimates of health‐related quality of life (HRQoL) and work/school absences for influenza are typically based on medically attended cases or those meeting influenza‐like‐illness (ILI) case definitions and thus biased towards severe disea... Read More about Effects of seasonal and pandemic influenza on health-related quality of life, work and school absence in England: Results from the Flu Watch cohort study.

Systematic review of respiratory viral pathogens identified in adults with community-acquired pneumonia in Europe (2017)
Journal Article
Alimi, Y., Lim, W., Lansbury, L. E., Leonardi-Bee, J., & Nguyen-Van-Tam, J. S. (2017). Systematic review of respiratory viral pathogens identified in adults with community-acquired pneumonia in Europe. Journal of Clinical Virology, 95, https://doi.org/10.1016/j.jcv.2017.07.019

Community-acquired pneumonia (CAP) is an important respiratory disease and the fifth leading cause of mortality in Europe. The development of molecular diagnostic tests has highlighted the contributions of respiratory viruses to the aetiology of CAP,... Read More about Systematic review of respiratory viral pathogens identified in adults with community-acquired pneumonia in Europe.

Influenza in long-term care facilities (2017)
Journal Article
Lansbury, L. E., Brown, C. S., & Nguyen-Van-Tam, J. S. (2017). Influenza in long-term care facilities. Influenza and Other Respiratory Viruses, 11(5), 356-366. https://doi.org/10.1111/irv.12464

Long-term care facility environments and the vulnerability of their residents provide a setting conducive to the rapid spread of influenza virus and other respiratory pathogens. Infections may be introduced by staff, visitors or new or transferred re... Read More about Influenza in long-term care facilities.

Evidence synthesis and decision modelling to support complex decisions: stockpiling neuraminidase inhibitors for pandemic influenza usage (2017)
Journal Article
Watson, S. I., Chen, Y.-F., Nguyen-Van-Tam, J. S., Myles, P. R., Venkatesan, S., Zambon, M., …Lilford, R. J. (2017). Evidence synthesis and decision modelling to support complex decisions: stockpiling neuraminidase inhibitors for pandemic influenza usage. F1000Research, 5, Article 2293. https://doi.org/10.12688/f1000research.9414.2

Objectives: The stockpiling of neuraminidase inhibitor (NAI) antivirals as a defence against pandemic influenza is a significant public health policy decision that must be made despite a lack of conclusive evidence from randomised controlled trials r... Read More about Evidence synthesis and decision modelling to support complex decisions: stockpiling neuraminidase inhibitors for pandemic influenza usage.

Evidence synthesis and decision modelling to support complex decisions: stockpiling neuraminidase inhibitors for pandemic influenza usage (2017)
Journal Article
Watson, S. I., Chen, Y.-F., Nguyen-Van-Tam, J. S., Myles, P. R., Venkatesan, S., Zambon, M., …Lilford, R. J. (2017). Evidence synthesis and decision modelling to support complex decisions: stockpiling neuraminidase inhibitors for pandemic influenza usage. F1000Research, 5, Article 2293. https://doi.org/10.12688/f1000research.9414.2

Objectives: The stockpiling of neuraminidase inhibitor (NAI) antivirals as a defence against pandemic influenza is a significant public health policy decision that must be made despite a lack of conclusive evidence from randomised controlled trials r... Read More about Evidence synthesis and decision modelling to support complex decisions: stockpiling neuraminidase inhibitors for pandemic influenza usage.

Effectiveness of 2009 pandemic influenza A(H1N1) vaccines: a systematic review and meta-analysis (2017)
Journal Article
Lansbury, L. E., Smith, S., Beyer, W., Karamehic, E., Pasic-Juhas, E., Sikira, H., …Nguyen-Van-Tam, J. (in press). Effectiveness of 2009 pandemic influenza A(H1N1) vaccines: a systematic review and meta-analysis. Vaccine, https://doi.org/10.1016/j.vaccine.2017.02.059

Background: The clinical effectiveness of monovalent influenza A(H1N1)pdm09 vaccines has not been comprehensively summarised. We undertook a systematic review and meta-analysis to assess vaccine effectiveness (VE) for adjuvanted and unadjuvanted vacc... Read More about Effectiveness of 2009 pandemic influenza A(H1N1) vaccines: a systematic review and meta-analysis.

Middle East respiratory syndrome (2017)
Journal Article
Arabi, Y. M., Balkhy, H. H., Hayden, F. G., Bouchama, A., Luke, T., Baillie, J. K., …Fowler, R. A. (2017). Middle East respiratory syndrome. New England Journal of Medicine, 376(6), 584-594. https://doi.org/10.1056/NEJMsr1408795

The Middle East respiratory syndrome is caused by a coronavirus that was first identified in Saudi Arabia in 2012. Periodic outbreaks continue to occur in the Middle East and elsewhere. This report provides the latest information on MERS.

The association between benzodiazepines and influenza-like illness-related pneumonia and mortality: a survival analysis using UK Primary Care data (2016)
Journal Article
Nakafero, G., Sanders, R. D., Nguyen-Van-Tam, J. S., & Myles, P. R. (2016). The association between benzodiazepines and influenza-like illness-related pneumonia and mortality: a survival analysis using UK Primary Care data. Pharmacoepidemiology and Drug Safety, 25(11), 1263-1273. https://doi.org/10.1002/pds.4028

Purpose: Bacterial superinfections, including pneumonia, are frequent complications of influenza-like illness (ILI). Clinical and laboratory evidence suggests that benzodiazepines and Z-drugs may influence susceptibility to infections and mortality.... Read More about The association between benzodiazepines and influenza-like illness-related pneumonia and mortality: a survival analysis using UK Primary Care data.

Risk of nosocomial respiratory syncytial virus infection and effectiveness of control measures to prevent transmission events: a systematic review (2016)
Journal Article
French, C. E., McKenzie, B. C., Coope, C., Rajanaidu, S., Paranthaman, K., Pebody, R., …Beck, C. R. (2016). Risk of nosocomial respiratory syncytial virus infection and effectiveness of control measures to prevent transmission events: a systematic review. Influenza and Other Respiratory Viruses, 10(4), 268-290. https://doi.org/10.1111/irv.12379

Respiratory syncytial virus (RSV) causes a significant public health burden, and outbreaks among vulnerable patients in hospital settings are of particular concern. We reviewed published and unpublished literature from hospital settings to assess: (i... Read More about Risk of nosocomial respiratory syncytial virus infection and effectiveness of control measures to prevent transmission events: a systematic review.

Corticosteroids as adjunctive therapy in the treatment of influenza (2016)
Journal Article
Rodrigo, C., Leonardi-Bee, J., Nguyen-Van-Tam, J., & Lim, W. S. (2016). Corticosteroids as adjunctive therapy in the treatment of influenza. Cochrane Database of Systematic Reviews, Article CD010406. https://doi.org/10.1002/14651858.CD010406.pub2

Background: Specific treatments for influenza are limited to neuraminidase inhibitors and adamantanes. Corticosteroids show evidence of benefit in sepsis and related conditions, most likely due to their anti-inflammatory and immunomodulatory properti... Read More about Corticosteroids as adjunctive therapy in the treatment of influenza.

Cohort profile: the Flu Watch Study (2016)
Journal Article
Fragaszy, E. B., Warren-Gash, C., Wang, L., Copas, A., Dukes, O., Edmunds, W. J., …Hayward, A. C. (in press). Cohort profile: the Flu Watch Study. International Journal of Epidemiology, https://doi.org/10.1093/ije/dyv370

Influenza is a common, highly contagious respiratory virus which infects all age groups, causing a range of outcomes from asymptomatic infection and mild respiratory disease to severe respiratory disease and death.1 If infected, the adaptive immune s... Read More about Cohort profile: the Flu Watch Study.

The roles of transportation and transportation hubs in the propagation of influenza and coronaviruses: a systematic review (2016)
Journal Article
Browne, A., Ahmad, S. S.-O., Beck, C. R., & Nguyen-Van-Tam, J. (in press). The roles of transportation and transportation hubs in the propagation of influenza and coronaviruses: a systematic review. Journal of Travel Medicine, 23(1), https://doi.org/10.1093/jtm/tav002

BACKGROUND: Respiratory viruses spread in humans across wide geographical areas in short periods of time, resulting in high levels of morbidity and mortality. We undertook a systematic review to assess the evidence that air, ground and sea mass trans... Read More about The roles of transportation and transportation hubs in the propagation of influenza and coronaviruses: a systematic review.

Influenza vaccines really work? Keeping apart the true from the false (2015)
Journal Article
Nguyen-Van-Tam, J., Gross, D., Sturkenboom, M., & Parrish-Sprowl, J. (2015). Influenza vaccines really work? Keeping apart the true from the false. Vaccine, 33(49), https://doi.org/10.1016/j.vaccine.2015.08.052

A yearly seasonal flu vaccine is the best preventive method we have against influenza at this time. Even then, vaccination adoption is hampered by on-going discussions about safety and effectiveness. In order to dot the I's and cross the T's at the f... Read More about Influenza vaccines really work? Keeping apart the true from the false.

Evaluation of the ‘Live Life Better Service’, a community-based weight management service, for morbidly obese patients (2015)
Journal Article
Wallace, D., Myles, P., Holt, R., & Van-Tam, J. N. (2016). Evaluation of the ‘Live Life Better Service’, a community-based weight management service, for morbidly obese patients. Journal of Public Health, 38(2), e138-e149. https://doi.org/10.1093/pubmed/fdv103

Background There is a limited evidence on the effectiveness of lifestyle interventions in achieving and maintaining a significant level of weight loss in morbidly obese patients. This study evaluated the impact on weight loss and psychological wel... Read More about Evaluation of the ‘Live Life Better Service’, a community-based weight management service, for morbidly obese patients.

Natural T Cell–mediated Protection against Seasonal and Pandemic Influenza. Results of the Flu Watch Cohort Study (2015)
Journal Article
Hayward, A. C., Wang, L., Goonetilleke, N., Fragaszy, E. B., Bermingham, A., Copas, A., …McMichael, A. J. (2015). Natural T Cell–mediated Protection against Seasonal and Pandemic Influenza. Results of the Flu Watch Cohort Study. American Journal of Respiratory and Critical Care Medicine, 191(12), 1422-1431. https://doi.org/10.1164/rccm.201411-1988oc

Rationale: A high proportion of influenza infections are asymptomatic. Animal and human challenge studies and observational studies suggest T cells protect against disease among those infected, but the impact of T-cell immunity at the population leve... Read More about Natural T Cell–mediated Protection against Seasonal and Pandemic Influenza. Results of the Flu Watch Cohort Study.

Association between benzodiazepine use and exacerbations and mortality in patients with asthma: a matched case-control and survival analysis using the United Kingdom Clinical Practice Research Datalink (2015)
Journal Article
Nakafero, G., Sanders, R. D., Nguyen-Van-Tam, J. S., & Myles, P. R. (2015). Association between benzodiazepine use and exacerbations and mortality in patients with asthma: a matched case-control and survival analysis using the United Kingdom Clinical Practice Research Datalink. Pharmacoepidemiology and Drug Safety, 24(8), 793-802. https://doi.org/10.1002/pds.3799

Purpose: To investigate the association between the GABAergic drugs, benzodiazepines or zopiclone, and the occurrence of asthma exacerbations and subsequent mortality in a cohort of asthma patients. Methods: 105,747 patients without asthma exacerba... Read More about Association between benzodiazepine use and exacerbations and mortality in patients with asthma: a matched case-control and survival analysis using the United Kingdom Clinical Practice Research Datalink.