Monitoring the Dissolution Mechanisms of Amorphous Bicalutamide Solid Dispersions via Real-Time Raman Mapping

Tres, Francesco; Aylott, Jonathan; Patient, Jamie D.; Williams, Philip M.; Treacher, Kevin; Booth, Jonathan; Hughes, Leslie P.; Wren, Stephen A.C.; Burley, Jonathan C.

doi:10.1021/mp500829v

All Outputs (6)

3D printing of tablets containing multiple drugs with defined release profiles (2015)
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3D printing of five-in-one dose combination polypill with defined immediate and sustained release profiles (2015)
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We have used three dimensional (3D) extrusion printing to manufacture a multi-active solid dosage form or so called polypill. This contains five compartmentalised drugs with two independently controlled and well-defined release profiles. This polypil... Read More about 3D printing of five-in-one dose combination polypill with defined immediate and sustained release profiles.

Investigating the dissolution performance of amorphous solid dispersions using magnetic resonance imaging and proton NMR (2015)
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Insights into the influence of the cooling profile on the reconstitution times of amorphous lyophilized protein formulations (2015)
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Lyophilized protein formulations must be reconstituted back into solution prior to patient administration and in this regard long reconstitution times are not ideal. The factors that govern reconstitution time remain poorly understood. The aim of thi... Read More about Insights into the influence of the cooling profile on the reconstitution times of amorphous lyophilized protein formulations.

The influence of polymer content on early gel-layer formation in HPMC matrices: the use of CLSM visualisation to identify the percolation threshold (2015)
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Monitoring the Dissolution Mechanisms of Amorphous Bicalutamide Solid Dispersions via Real-Time Raman Mapping (2015)
Journal Article

Real-time in situ Raman mapping has been employed to monitor, during dissolution, the crystallization transitions of amorphous bicalutamide formulated as a molecular dispersion in a copovidone VA64 matrix. The dissolution performance was also investi... Read More about Monitoring the Dissolution Mechanisms of Amorphous Bicalutamide Solid Dispersions via Real-Time Raman Mapping.