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Discovery and Prevalence of Divergent RNA Viruses in European Field Voles and Rabbits (2019)
Journal Article
Tsoleridis, T., Chappell, J. G., Monchatre-Leroy, E., Umhang, G., Shi, M., Bennett, M., …Ball, J. K. (2019). Discovery and Prevalence of Divergent RNA Viruses in European Field Voles and Rabbits. Viruses, 12(1), https://doi.org/10.3390/v12010047

The advent of unbiased metagenomic virus discovery has revolutionized studies of virus biodiversity and evolution. Despite this, our knowledge of the virosphere, including in mammalian species, remains limited. We used unbiased metagenomic sequencing... Read More about Discovery and Prevalence of Divergent RNA Viruses in European Field Voles and Rabbits.

IFITMs mediate viral evasion in acute and chronic hepatitis C virus infection (2019)
Journal Article
Wrensch, F., Ligat, G., Heydmann, L., Schuster, C., Zeisel, M. B., Pessaux, P., …Baumert, T. F. (2019). IFITMs mediate viral evasion in acute and chronic hepatitis C virus infection. Hepatology, 70(5), 1506-1520. https://doi.org/10.1002/hep.30699

While adaptive immune responses against hepatitis C virus (HCV) infection have been studied in great detail, the role of innate immunity in protection against HCV infection and immune evasion is only partially understood. Interferon‐induced transmemb... Read More about IFITMs mediate viral evasion in acute and chronic hepatitis C virus infection.

Cross-genotype AR3-specific neutralizing antibodies confer long-term protection in injecting drug users after HCV clearance (2019)
Journal Article
Merat, S. J., Bru, C., van de Berg, D., Molenkamp, R., Tarr, A. W., Koekkoek, S., …Schinkel, J. (2019). Cross-genotype AR3-specific neutralizing antibodies confer long-term protection in injecting drug users after HCV clearance. Journal of Hepatology, 71(1), 14-24. doi:10.1016/j.jhep.2019.02.013

Background & Aims Understanding immune protection against hepatitis C virus (HCV) infection is necessary for designing an effective vaccine. A number of broadly-reactive, neutralizing antibodies have been isolated from B cells of HCV-infected subjec... Read More about Cross-genotype AR3-specific neutralizing antibodies confer long-term protection in injecting drug users after HCV clearance.

Expression of human ficolin-2 in hepatocytes confers resistance to infection by diverse hepatotropic viruses (2019)
Journal Article
Irving, W. L., Jalal, P. J., Urbanowicz, R. A., Horncastle, E., Pathak, M., Goddard, C., …Tarr, A. W. (2019). Expression of human ficolin-2 in hepatocytes confers resistance to infection by diverse hepatotropic viruses. Journal of Medical Microbiology, 68(4), 642-648. https://doi.org/10.1099/jmm.0.000935

The liver-expressed pattern recognition receptors (PRRs) mannose binding lectin (MBL), ficolin-2 and ficolin-3 contribute to the innate immune response by activating complement. Binding of soluble ficolin-2 to viral pathogens can directly neutralize... Read More about Expression of human ficolin-2 in hepatocytes confers resistance to infection by diverse hepatotropic viruses.

Shared common ancestry of rodent alphacoronaviruses sampled globally (2019)
Journal Article
Tsoleridis, T., Chappell, J. G., Onianwa, O., Marston, D. A., Fooks, A. R., Monchatre‐leroy, E., …K 7 Ball, J. (2019). Shared common ancestry of rodent alphacoronaviruses sampled globally. Viruses, 11(2), doi:10.3390/v11020125

The recent discovery of novel alphacoronaviruses (alpha-CoVs) in European and Asian rodents revealed that rodent coronaviruses (CoVs) sampled worldwide formed a discrete phylogenetic group within this genus. To determine the evolutionary history of r... Read More about Shared common ancestry of rodent alphacoronaviruses sampled globally.

Antigenicity and immunogenicity of differentially glycosylated HCV E2 envelope proteins expressed in mammalian and insect cells (2019)
Journal Article
Urbanowicz, R. A., Wang, R., Schiel, J. E., Keck, Z., Kerzic, M. C., Lau, P., …Fuerst, T. R. (2019). Antigenicity and immunogenicity of differentially glycosylated HCV E2 envelope proteins expressed in mammalian and insect cells. Journal of Virology, doi:10.1128/jvi.01403-18

Development of a prophylactic vaccine for hepatitis C virus (HCV) remains a global health challenge. Cumulative evidence supports the importance of antibodies targeting the HCV E2 envelope glycoprotein to facilitate viral clearance. However, a signif... Read More about Antigenicity and immunogenicity of differentially glycosylated HCV E2 envelope proteins expressed in mammalian and insect cells.


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