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A protocol to assess risk of fractures associated with use of menopausal hormone therapy: nested case-control study using CPRD (2024)
Preprint / Working Paper
Vinogradova, Y., Iyen, B., Masud, T., Taylor, L., & Kai, J. A protocol to assess risk of fractures associated with use of menopausal hormone therapy: nested case-control study using CPRD

Menopausal hormone therapy (MHT) is prescribed to women with severe symptoms of menopause. Various studies have demonstrated increased bone density and decreased fracture risk in women using MHT. The randomised controlled trials were, however, run ov... Read More about A protocol to assess risk of fractures associated with use of menopausal hormone therapy: nested case-control study using CPRD.

Precision Medicine—Are We There Yet? A Narrative Review of Precision Medicine’s Applicability in Primary Care (2024)
Journal Article
Evans, W., Meslin, E. M., Kai, J., & Qureshi, N. (2024). Precision Medicine—Are We There Yet? A Narrative Review of Precision Medicine’s Applicability in Primary Care. Journal of Personalized Medicine, 14(4), Article 418. https://doi.org/10.3390/jpm14040418

Precision medicine (PM), also termed stratified, individualised, targeted, or personalised medicine, embraces a rapidly expanding area of research, knowledge, and practice. It brings together two emerging health technologies to deliver better individ... Read More about Precision Medicine—Are We There Yet? A Narrative Review of Precision Medicine’s Applicability in Primary Care.

Experiences of coordinated care for people in the UK affected by rare diseases: cross-sectional survey of patients, carers, and healthcare professionals (2023)
Journal Article
Walton, H., Ng, P. L., Simpson, A., Bloom, L., Chitty, L. S., Fulop, N. J., …Morris, S. (2023). Experiences of coordinated care for people in the UK affected by rare diseases: cross-sectional survey of patients, carers, and healthcare professionals. Orphanet Journal of Rare Diseases, 18(1), Article 364. https://doi.org/10.1186/s13023-023-02934-9

Background
Poorly coordinated care can have major impacts on patients and families affected by rare conditions, with negative physical health, psychosocial and financial consequences. This study aimed to understand how care is coordinated for rare d... Read More about Experiences of coordinated care for people in the UK affected by rare diseases: cross-sectional survey of patients, carers, and healthcare professionals.

Alternative cascade-testing protocols for identifying and managing patients with familial hypercholesterolaemia: systematic reviews, qualitative study and cost-effectiveness analysis (2023)
Journal Article
Qureshi, N., Woods, B., Neves de Faria, R., Saramago Goncalves, P., Cox, E., Leonardi Bee, J., …Kai, J. (2023). Alternative cascade-testing protocols for identifying and managing patients with familial hypercholesterolaemia: systematic reviews, qualitative study and cost-effectiveness analysis. Health Technology Assessment, 27(16), https://doi.org/10.3310/CTMD0148

Background
Cascade testing the relatives of people with familial hypercholesterolaemia is an efficient approach to identifying familial hypercholesterolaemia. The cascade-testing protocol starts with identifying an index patient with familial hyperc... Read More about Alternative cascade-testing protocols for identifying and managing patients with familial hypercholesterolaemia: systematic reviews, qualitative study and cost-effectiveness analysis.

Rates of medical or surgical treatment for women with heavy menstrual bleeding: the ECLIPSE trial 10-year observational follow-up study (2023)
Journal Article
Kai, J., Dutton, B., Vinogradova, Y., Hilken, N., Gupta, J., & Daniels, J. (2023). Rates of medical or surgical treatment for women with heavy menstrual bleeding: the ECLIPSE trial 10-year observational follow-up study. Health Technology Assessment, 27(17), https://doi.org/10.3310/jhsw0174

Background: Heavy menstrual bleeding is a common problem that can significantly affect women’s lives until menopause. There is a lack of evidence on longer-term outcomes after seeking health care and treatment for heavy menstrual bleeding. Objectives... Read More about Rates of medical or surgical treatment for women with heavy menstrual bleeding: the ECLIPSE trial 10-year observational follow-up study.

A population-based study exploring phenotypic clusters and clinical outcomes in stroke using unsupervised machine learning approach (2023)
Journal Article
Akyea, R. K., Ntaios, G., Kontopantelis, E., Georgiopoulos, G., Soria, D., Asselbergs, F. W., …Qureshi, N. (2023). A population-based study exploring phenotypic clusters and clinical outcomes in stroke using unsupervised machine learning approach. PLOS Digital Health, 2(9), Article e0000334. https://doi.org/10.1371/journal.pdig.0000334

Individuals developing stroke have varying clinical characteristics, demographic, and biochemical profiles. This heterogeneity in phenotypic characteristics can impact on cardiovascular disease (CVD) morbidity and mortality outcomes. This study uses... Read More about A population-based study exploring phenotypic clusters and clinical outcomes in stroke using unsupervised machine learning approach.

Multinational prescribing trends of lithium from 2001 to 2019: a retrospective observational study using population-based databases from 17 countries and one special administrative region (2023)
Journal Article
Chan, A. Y., Chan, V. K., Bahmanyar, S., Beyene, K., Bushnell, G., Carleton, B., …Wong, I. C. K. Multinational prescribing trends of lithium from 2001 to 2019: a retrospective observational study using population-based databases from 17 countries and one special administrative region. Manuscript submitted for publication

Implementation of a diabetes prevention programme in a multi-ethnic community in primary care in England: An evaluation using constructs from the RE-AIM Framework (2023)
Journal Article
Dallosso, H., Khunti, K., Gray, L. J., Hulley, K., Ghaly, M., Patel, N., …Yates, T. (2023). Implementation of a diabetes prevention programme in a multi-ethnic community in primary care in England: An evaluation using constructs from the RE-AIM Framework. Primary Care Diabetes, 17(4), 309-313. https://doi.org/10.1016/j.pcd.2023.05.001

Aims: To implement a diabetes prevention programme in primary care Methods: The programme was implemented for 12 months in two neighbouring towns, served by eight general practices. Practices requested a referral pathway involving an external adminis... Read More about Implementation of a diabetes prevention programme in a multi-ethnic community in primary care in England: An evaluation using constructs from the RE-AIM Framework.