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All Outputs (84)

Primary liver cancer risk and mortality in patients with alcohol-related cirrhosis in England and Denmark: observational cohort studies (2024)
Journal Article
Jensen, M. D., West, J., Crooks, C., Morling, J. R., Kraglund, F., Card, T., Askgaard, G., & Jepsen, P. (2024). Primary liver cancer risk and mortality in patients with alcohol-related cirrhosis in England and Denmark: observational cohort studies. American Journal of Gastroenterology, https://doi.org/10.14309/ajg.0000000000003077

Background & Aims:

Patients with alcohol-related cirrhosis (ALD cirrhosis) have an increased risk of primary liver cancer (hepatocellular carcinoma [HCC] or intrahepatic cholangiocarcinoma [iCCA]). England recommends surveillance for HCC in these... Read More about Primary liver cancer risk and mortality in patients with alcohol-related cirrhosis in England and Denmark: observational cohort studies.

Bringing the voice of social housing tenants into shaping the health and care research agenda (2024)
Journal Article
Phillips, O. R., Mardell, D., Stephenson, K., Hussain, S., Burton, D., Bernard, B., Stevenson, S., & Morling, J. R. (2024). Bringing the voice of social housing tenants into shaping the health and care research agenda. Research Involvement and Engagement, 10, Article 85. https://doi.org/10.1186/s40900-024-00613-y

Background: A larger percentage of social housing tenants have poorer physical and mental health outcomes compared to private renters and homeowners. They are also at a greater risk of respiratory conditions, cardiovascular disease, communicable dise... Read More about Bringing the voice of social housing tenants into shaping the health and care research agenda.

A requirement for the use of supplementary oxygen to guide medical treatment decisions may introduce bias against non-white individuals (2024)
Journal Article
Crooks, C. J., West, J., Morling, J. R., Simmonds, M., Juurlink, I., Briggs, S., Cruickshank, S., Hammond-Pears, S., Shaw, D., Card, T. R., & Fogarty, A. W. (2024). A requirement for the use of supplementary oxygen to guide medical treatment decisions may introduce bias against non-white individuals. European Respiratory Journal, 63(6), Article 2302320. https://doi.org/10.1183/13993003.02320-2023

What are the strengths and limitations to utilising creative methods in public and patient involvement in health and social care research? A qualitative systematic review (2024)
Journal Article
Phillips, O. R., Harries, C., Leonardi-Bee, J., Knight, H., Sherar, L. B., Varela-Mato, V., & Morling, J. R. (2024). What are the strengths and limitations to utilising creative methods in public and patient involvement in health and social care research? A qualitative systematic review. Research Involvement and Engagement, 10(1), Article 48. https://doi.org/10.1186/s40900-024-00580-4

Background: There is increasing interest in using patient and public involvement (PPI) in research to improve the quality of healthcare. Ordinarily, traditional methods have been used such as interviews or focus groups. However, these methods tend to... Read More about What are the strengths and limitations to utilising creative methods in public and patient involvement in health and social care research? A qualitative systematic review.

Facilitators and barriers to asylum seeker and refugee oral health care access: a qualitative systematic review (2024)
Journal Article
Wainman, N. E., Phillips, O. . R., & Morling, J. R. (2024). Facilitators and barriers to asylum seeker and refugee oral health care access: a qualitative systematic review. British Dental Journal, https://doi.org/10.1038/s41415-024-7235-9

Objectives Asylum seekers and refugees (ASRs) encounter barriers when accessing oral health care (OHC). A qualitative systematic review was conducted to understand the perceptions, attitudes, behaviours and experiences of ASRs regarding their OHC. Th... Read More about Facilitators and barriers to asylum seeker and refugee oral health care access: a qualitative systematic review.

Top ten research priorities for alcohol use disorder and alcohol-related liver disease: results of a multistakeholder research priority setting partnership (2024)
Journal Article
Subhani, M., Dhanda, A., Olaru, A., Dunford, L., Ahmad, N., Wragg, A., Frost, K., Greenwood, J., King, M., Jones, K. A., Rosenberg, W., Sinclair, J., Rennick-Egglestone, S., Morling, J. R., Patel, K., & Ryder, S. D. (2024). Top ten research priorities for alcohol use disorder and alcohol-related liver disease: results of a multistakeholder research priority setting partnership. The Lancet Gastroenterology & Hepatology, 9(5), 400-402. https://doi.org/10.1016/S2468-1253%2824%2900009-8

Alcohol is a preventable leading cause of liver disease and over 200 other acute or chronic medical conditions. 1 In the UK, 25% of the population drinks at an increasing risk level (ie, 15–34 units per week for women and 15–49 units per week for men... Read More about Top ten research priorities for alcohol use disorder and alcohol-related liver disease: results of a multistakeholder research priority setting partnership.

Population-based study of alcohol-related liver disease in England 2001-2018: Influence of socioeconomic position (2024)
Journal Article
Askgaard, G., Jepsen, P., Jensen, M. D., Kann, A. E., Morling, J., Kraglund, F., Card, T., Crooks, C., & West, J. (2024). Population-based study of alcohol-related liver disease in England 2001-2018: Influence of socioeconomic position. American Journal of Gastroenterology, 119(7), 1337-1345. https://doi.org/10.14309/ajg.0000000000002677

INTRODUCTION:
England has seen an increase in deaths due to alcohol-related liver disease (ALD) since 2001. We studied the influence of socioeconomic position on the incidence of ALD and the mortality after ALD diagnosis in England in 2001–2018.... Read More about Population-based study of alcohol-related liver disease in England 2001-2018: Influence of socioeconomic position.

‘Low’ faecal immunochemical test (FIT) colorectal cancer: a 4-year comparison of the Nottingham ‘4F’ protocol with FIT10 in symptomatic patients (2024)
Journal Article
Bailey, J. A., Morton, A. J., Jones, J., Oliver, S., Morling, J. R., Patel, H., …Banergee, A. (2024). ‘Low’ faecal immunochemical test (FIT) colorectal cancer: a 4-year comparison of the Nottingham ‘4F’ protocol with FIT10 in symptomatic patients. Colorectal Disease, 26(2), 309-316. https://doi.org/10.1111/codi.16848

Aim:

To evaluate colorectal cancer outcomes after “low” (sub-threshold) Faecal Immunochemical Test (FIT) results in symptomatic patients tested in primary care.

Method:

Retrospective audit of 35,289 patients with FIT results, having consulte... Read More about ‘Low’ faecal immunochemical test (FIT) colorectal cancer: a 4-year comparison of the Nottingham ‘4F’ protocol with FIT10 in symptomatic patients.

‘Low’ faecal immunochemical test (FIT) colorectal cancer: a 4-year comparison of the Nottingham ‘4F’ protocol with FIT10 in symptomatic patients (2024)
Journal Article
Bailey, J. A., Morton, A. J., Jones, J., Chapman, C. J., Oliver, S., Morling, J. R., …Banerjea, A. (2024). ‘Low’ faecal immunochemical test (FIT) colorectal cancer: a 4-year comparison of the Nottingham ‘4F’ protocol with FIT10 in symptomatic patients. Colorectal Disease, 26(2), 309-316. https://doi.org/10.1111/codi.16848

Aim
The aim of this work was to evaluate colorectal cancer (CRC) outcomes after ‘low’ (sub-threshold) faecal immunochemical test (FIT) results in symptomatic patients tested in primary care.

Method
This work comprised a retrospective audit of 3... Read More about ‘Low’ faecal immunochemical test (FIT) colorectal cancer: a 4-year comparison of the Nottingham ‘4F’ protocol with FIT10 in symptomatic patients.

Risk of alcohol-related liver disease in the offspring of parents with alcohol-related liver disease: A nationwide cohort study (2023)
Journal Article
Jepsen, P., West, J., Kann, A. E., Kraglund, F., Morling, J., Crooks, C., & Askgaard, G. (2024). Risk of alcohol-related liver disease in the offspring of parents with alcohol-related liver disease: A nationwide cohort study. Hepatology, 80(2), 418-427. https://doi.org/10.1097/hep.0000000000000747

Background and aims: Offspring of patients with alcohol-related liver disease (ALD) may have higher risk of ALD. We examined their risk of ALD and survival with ALD.

Approach & Results: We used Danish nationwide registries to identify offspring of... Read More about Risk of alcohol-related liver disease in the offspring of parents with alcohol-related liver disease: A nationwide cohort study.

Using a machine learning model to risk stratify for the presence of significant liver disease in a primary care population (2023)
Journal Article
Bennett, L., Mostafa, M., Hammersley, R., Purssell, H., Patel, M., Street, O., …Guha, I. N. (2023). Using a machine learning model to risk stratify for the presence of significant liver disease in a primary care population. Journal of Medical Artificial Intelligence, 6, Article 27. https://doi.org/10.21037/jmai-23-35

Background: Current strategies for detecting significant chronic liver disease (CLD) in the community are based on the extrapolation of diagnostic tests used in secondary care settings. Whilst this approach provides clinical utility, it has limitatio... Read More about Using a machine learning model to risk stratify for the presence of significant liver disease in a primary care population.

Sociodemographic Variations in the Uptake of Faecal Immunochemical Tests in Primary Care (2023)
Journal Article
Bailey, J. A., Morton, A. J., Jones, J., Chapman, C. J., Oliver, S., Morling, J. R., …Humes, D. J. (2023). Sociodemographic Variations in the Uptake of Faecal Immunochemical Tests in Primary Care. British Journal of General Practice, 73(736), e843-e849. https://doi.org/10.3399/bjgp.2023.0033

Background: Faecal Immunochemical Testing (FIT) usage for symptomatic patients is increasing, but variations in use by sociodemographics are unknown. We introduced FIT for symptomatic patients in November 2017. Aim: Identify whether demographics, eth... Read More about Sociodemographic Variations in the Uptake of Faecal Immunochemical Tests in Primary Care.

Transient elastography and video recovery narrative access to support recovery from alcohol misuse: development of a novel intervention for use in community alcohol treatment services (2023)
Journal Article
Rennick-Egglestone, S., Subhani, M., Knight, H., Jones, K. A., Hutton, C., Jackson, T., …Ryder, S. (2023). Transient elastography and video recovery narrative access to support recovery from alcohol misuse: development of a novel intervention for use in community alcohol treatment services. JMIR Formative Research, 7, Article e47109. https://doi.org/10.2196/47109

Background: Mortality from alcohol-related liver disease has risen significantly for three decades. Transient elastography (TE) is a non-invasive test providing a numerical marker of liver disease. Preliminary evidence suggests that receiving TE can... Read More about Transient elastography and video recovery narrative access to support recovery from alcohol misuse: development of a novel intervention for use in community alcohol treatment services.

Application and Extension of the Alcohol Recovery Narratives Conceptual Framework (2023)
Journal Article
Subhani, M., Talat, U., Knight, H., Morling, J. R., Jones, K. A., Aithal, G. P., …Rennick-Egglestone, S. (2023). Application and Extension of the Alcohol Recovery Narratives Conceptual Framework. Qualitative Health Research, 33(13), 1203-1217. https://doi.org/10.1177/10497323231197384

Recovery narratives are personal stories of health problems and recovery. A systematic review proposed a conceptual framework characterising alcohol misuse recovery narratives, consisting of eight principal dimensions, each with types and subtypes. T... Read More about Application and Extension of the Alcohol Recovery Narratives Conceptual Framework.

Mortality rates among patients successfully treated for hepatitis C in the era of interferon-free antivirals: population based cohort study (2023)
Journal Article
Hamill, V., Wong, S., Benselin, J., Krajden, M., Hayes, P. C., Mutimer, D., …Innes, H. (2023). Mortality rates among patients successfully treated for hepatitis C in the era of interferon-free antivirals: population based cohort study. BMJ, 382, Article e074001. https://doi.org/10.1136/bmj-2022-074001

Objectives To quantify mortality rates for patients successfully treated for hepatitis C in the era of interferon-free, direct acting antivirals and compare these rates with those of the general population.

Design Population based cohort study.... Read More about Mortality rates among patients successfully treated for hepatitis C in the era of interferon-free antivirals: population based cohort study.

Respiratory rate responses to both hypercapnia and acidaemia are modified by age in patients with acidosis (2023)
Journal Article
Crooks, C. J., West, J., Morling, J. R., Simmonds, M., Juurlink, I., Briggs, S., …Fogarty, A. W. (2023). Respiratory rate responses to both hypercapnia and acidaemia are modified by age in patients with acidosis. Respiratory Physiology and Neurobiology, 315, Article 104098. https://doi.org/10.1016/j.resp.2023.104098

Objective
To explore the associations between arterial pO2, pCO2 and pH and how these are modified by age.

Methods
An analysis of 2598 patients admitted with a diagnosis of Covid-19 infection to a large UK teaching hospital.

Results
There we... Read More about Respiratory rate responses to both hypercapnia and acidaemia are modified by age in patients with acidosis.

Does knowledge of liver fibrosis affect high-risk drinking behaviour (KLIFAD): an open-label pragmatic feasibility randomised controlled trial (2023)
Journal Article
Subhani, M., Enki, D. G., Knight, H., Jones, K. A., Sprange, K., Rennick-Egglestone, S., …Ryder, S. D. (2023). Does knowledge of liver fibrosis affect high-risk drinking behaviour (KLIFAD): an open-label pragmatic feasibility randomised controlled trial. eClinicalMedicine, 61, Article 102069. https://doi.org/10.1016/j.eclinm.2023.102069

Background: Early identification followed by effective behaviour interventions is pivotal to changing the natural history of alcohol-related liver disease. We examined the feasibility of using transient elastography based advice and alcohol recovery... Read More about Does knowledge of liver fibrosis affect high-risk drinking behaviour (KLIFAD): an open-label pragmatic feasibility randomised controlled trial.

Prevalence of Non-alcoholic Fatty Liver Disease (NAFLD) in Saudi Arabia: Systematic Review and Meta-analysis (2023)
Journal Article
Alenezi, Y. . M., Harris, R., Morling, J., & Card, T. (2023). Prevalence of Non-alcoholic Fatty Liver Disease (NAFLD) in Saudi Arabia: Systematic Review and Meta-analysis. Cureus, 15(6), Article e40308. https://doi.org/10.7759/cureus.40308

Liver disease is fast emerging as a global health priority. Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in Western countries, with an increasing prevalence associated with the rising prevalence of diabetes mellitus and... Read More about Prevalence of Non-alcoholic Fatty Liver Disease (NAFLD) in Saudi Arabia: Systematic Review and Meta-analysis.