Development of a Gene-Activated Scaffold Incorporating Multifunctional Cell-Penetrating Peptides for pSDF-1α Delivery for Enhanced Angiogenesis in Tissue Engineering Applications

Power, Rachael N.; Cavanagh, Brenton L.; Dixon, James E.; Curtin, Caroline M.; O’Brien, Fergal J.

doi:10.3390/ijms23031460

All Outputs (3)

Direct contact-mediated non-viral gene therapy using thermo-sensitive hydrogel-coated dressings (2022)
Journal Article
Eltaher, H. M., Blokpoel Ferreras, L. A., Jalal, A. R., & Dixon, J. (2022). Direct contact-mediated non-viral gene therapy using thermo-sensitive hydrogel-coated dressings. Biomaterials Advances, 143, Article 213177. https://doi.org/10.1016/j.bioadv.2022.213177

Nanotechnologies are being increasingly applied as systems for peptide and nucleic acid macromolecule drug delivery. However systemic targeting of these, or efficient topical and localized delivery remains an issue. A controlled release system that c... Read More about Direct contact-mediated non-viral gene therapy using thermo-sensitive hydrogel-coated dressings.

RAPID INTRAOPERATIVE GENETIC AUGMENTATION OF AUTOGRAFTS FOR RECONSTRUCTIVE SURGERY OF SEVERE TRAUMA (2022)
Presentation / Conference Contribution
Dixon, J., Thi Mai, T., McLaren, J., Ollivere, B., Scammell, B., & Eltaher, H. (2022). RAPID INTRAOPERATIVE GENETIC AUGMENTATION OF AUTOGRAFTS FOR RECONSTRUCTIVE SURGERY OF SEVERE TRAUMA. Tissue Engineering: Parts A, B, and C, 28(S1),

Survivors with severe tissue injury have unmet clinical needs for better bone and soft tissue regeneration. Specifically they have progressive tissue loss due to inflammation, necrosis, infection and the development of critical size bone defects is a... Read More about RAPID INTRAOPERATIVE GENETIC AUGMENTATION OF AUTOGRAFTS FOR RECONSTRUCTIVE SURGERY OF SEVERE TRAUMA.

Development of a Gene-Activated Scaffold Incorporating Multifunctional Cell-Penetrating Peptides for pSDF-1α Delivery for Enhanced Angiogenesis in Tissue Engineering Applications (2022)
Journal Article
Power, R. N., Cavanagh, B. L., Dixon, J. E., Curtin, C. M., & O’Brien, F. J. (2022). Development of a Gene-Activated Scaffold Incorporating Multifunctional Cell-Penetrating Peptides for pSDF-1α Delivery for Enhanced Angiogenesis in Tissue Engineering Applications. International Journal of Molecular Sciences, 23(3), Article 1460. https://doi.org/10.3390/ijms23031460

Non-viral gene delivery has become a popular approach in tissue engineering, as it permits the transient delivery of a therapeutic gene, in order to stimulate tissue repair. However, the efficacy of non-viral delivery vectors remains an issue. Our la... Read More about Development of a Gene-Activated Scaffold Incorporating Multifunctional Cell-Penetrating Peptides for pSDF-1α Delivery for Enhanced Angiogenesis in Tissue Engineering Applications.