All Outputs (3)

Angiogenic and immune predictors of neoadjuvant axitinib response in renal cell carcinoma with venous tumour thrombus (2025)
Journal Article
Wray, R., Paverd, H., Machado, I., Barbieri, J., Easita, F., Edwards, A. R., Gallagher, F. A., Mendichovszky, I. A., Mitchell, T. J., De La Roche, M., Shields, J. D., Ursprung, S., Wallis, L., Warren, A. Y., Welsh, S. J., Crispin-Ortuzar, M., Stewart, G. D., & Jones, J. O. (2025). Angiogenic and immune predictors of neoadjuvant axitinib response in renal cell carcinoma with venous tumour thrombus. Nature Communications, 16, Article 3870

Venous tumour thrombus (VTT), where the primary tumour invades the renal vein and inferior vena cava, affects 10-15% of renal cell carcinoma (RCC) patients. Curative surgery for VTT is high-risk, but neoadjuvant therapy may improve outcomes. The NAXI... Read More about Angiogenic and immune predictors of neoadjuvant axitinib response in renal cell carcinoma with venous tumour thrombus.

Modelling structural and cellular elements and functional responses to lymphatic-delivered cues in a murine lymph node on a chip (2024)
Journal Article
Mazzaglia, C., Munir, H., Man Lei, I., Gerigk, M., Yan Shery Huang, Y., & Shields, J. (2024). Modelling structural and cellular elements and functional responses to lymphatic-delivered cues in a murine lymph node on a chip. Advanced Healthcare Materials, 13(18), Article 2303720. https://doi.org/10.1002/adhm.202303720

Lymph nodes (LNs) are organs of the immune system, critical for maintenance of homeostasis and initiation of immune responses, yet there are few models that accurately recapitulate LN functions in vitro. To tackle this issue, an engineered murine LN... Read More about Modelling structural and cellular elements and functional responses to lymphatic-delivered cues in a murine lymph node on a chip.

Disruption of CD47-SIRPα signaling restores inflammatory function in tumor-associated myeloid-derived suppressor cells (2024)
Journal Article
Zimarino, C., Moody, W., Davidson, S. E., Munir, H., & Shields, J. D. (2024). Disruption of CD47-SIRPα signaling restores inflammatory function in tumor-associated myeloid-derived suppressor cells. iScience, 27(4), Article 109546. https://doi.org/10.1016/j.isci.2024.109546

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous immune population with diverse immunosuppressive functions in solid tumors. Here, we explored the role of the tumor microenvironment in regulating MDSC differentiation and immunosuppressive... Read More about Disruption of CD47-SIRPα signaling restores inflammatory function in tumor-associated myeloid-derived suppressor cells.