Long-term exposure to irinotecan reduces cell migration in glioma cells.

Al-Ghafari, Ayat B.; Punjaruk, Wiyada; Storer, L.C.D.; Carrier, D.J.; Hussein, D.; Coyle, Beth; Kerr, Ian D.

doi:10.1007/s11060-016-2058-4

All Outputs (3)

Location of contact residues in pharmacologically distinct drug binding sites on P-glycoprotein (2016)
Journal Article
Mittra, R., Pavy, M., Subramanian, N., George, A. M., O'Mara, M. L., Kerr, I. D., & Callaghan, R. (2017). Location of contact residues in pharmacologically distinct drug binding sites on P-glycoprotein. Biochemical Pharmacology, 123, 19-28. https://doi.org/10.1016/j.bcp.2016.10.002

© 2016 Elsevier Inc. The multidrug resistance P-glycoprotein (P-gp) is characterised by the ability to bind and/or transport an astonishing array of drugs. This poly-specificity is imparted by at least four pharmacologically distinct binding sites wi... Read More about Location of contact residues in pharmacologically distinct drug binding sites on P-glycoprotein.

The multidrug transporter ABCG2: still more questions than answers (2016)
Journal Article
Horsey, A. J., Cox, M. H., Sarwat, S., & Kerr, I. D. (2016). The multidrug transporter ABCG2: still more questions than answers. Biochemical Society Transactions, 44(3), 824-830. https://doi.org/10.1042/BST20160014

ABCG2 is one of at least three human ATP binding cassette (ABC) transporters which can facilitate the export from cells of a wide range of chemically unrelated drug molecules. This capacity for multidrug transport is not only a confounding factor in... Read More about The multidrug transporter ABCG2: still more questions than answers.

Long-term exposure to irinotecan reduces cell migration in glioma cells. (2016)
Journal Article
Al-Ghafari, A. B., Punjaruk, W., Storer, L., Carrier, D., Hussein, D., Coyle, B., & Kerr, I. D. (2016). Long-term exposure to irinotecan reduces cell migration in glioma cells. Journal of Neuro-Oncology, 127(3), 455-462. https://doi.org/10.1007/s11060-016-2058-4

In spite of considerable research into the therapies for glioblastoma multiforme this tumour type remains very difficult to treat. As well as having a tendency to be inherently resistant to chemotherapy, glioblastoma multiforme also displays local in... Read More about Long-term exposure to irinotecan reduces cell migration in glioma cells..