All Outputs (2)

Detergent-free purification of ABC (ATP-binding-cassette) transporters (2014)
Journal Article
Gulati, S., Jamshad, M., Knowles, T. J., Morrison, K. A., Downing, R., Cant, N., …Rothnie, A. J. (2014). Detergent-free purification of ABC (ATP-binding-cassette) transporters. Biochemical Journal, 461(2), 269-278. https://doi.org/10.1042/BJ20131477

ABC (ATP-binding-cassette) transporters carry out many vital functions and are involved in numerous diseases, but study of the structure and function of these proteins is often hampered by their large size and membrane location. Membrane protein puri... Read More about Detergent-free purification of ABC (ATP-binding-cassette) transporters.

The central cavity of ABCB1 undergoes alternating access during ATP hydrolysis (2014)
Journal Article
van Wonderen, J. H., McMahon, R. M., OMara, M. L., McDevitt, C. A., Thomson, A. J., Kerr, I. D., …Callaghan, R. (2014). The central cavity of ABCB1 undergoes alternating access during ATP hydrolysis. FEBS Journal, 281(9), 2190-2201. https://doi.org/10.1111/febs.12773

Understanding the process that underlies multidrug recognition and efflux by P-glycoprotein (ABCB1) remains a key biological challenge. Structural data have recently become available for the murine and Caenorhabditis elegans homologues of ABCB1; howe... Read More about The central cavity of ABCB1 undergoes alternating access during ATP hydrolysis.