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Nepalese indoor cookstove smoke extracts alter human airway epithelial gene expression, DNA methylation and hydroxymethylation (2023)
Journal Article

Household air pollution caused by inefficient cooking practices causes 4 million deaths a year worldwide. In Nepal, 86% of the rural population use solid fuels for cooking. Over 25% of premature deaths associated with air pollution are respiratory in... Read More about Nepalese indoor cookstove smoke extracts alter human airway epithelial gene expression, DNA methylation and hydroxymethylation.

Genome-wide association study of chronic sputum production implicates loci involved in mucus production and infection (2023)
Journal Article

Chronic sputum production impacts on quality of life and is a feature of many respiratory diseases. Identification of the genetic variants associated with chronic sputum production in a disease agnostic sample could improve understanding of its cause... Read More about Genome-wide association study of chronic sputum production implicates loci involved in mucus production and infection.

Evaluation of outpatient treatment for non-hospitalised patients with COVID-19: The experience of a regional centre in the UK (2023)
Journal Article

Introduction Antivirals, such as molnupiravir, and SARS-CoV-2 neutralising monoclonal antibodies (nMAbs), such as sotrovimab, reduced the risk of hospitalisation and death in clinical trials of high-risk non-hospitalised patients with Covid-19. Howev... Read More about Evaluation of outpatient treatment for non-hospitalised patients with COVID-19: The experience of a regional centre in the UK.

Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk (2023)
Journal Article

Lung-function impairment underlies chronic obstructive pulmonary disease (COPD) and predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of lung function to date, comprising 580,869 participants, we identified 1,020... Read More about Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk.

Genome-wide association study of chronic sputum production implicates loci involved in mucus production and infection (2022)
Working Paper

Background Chronic sputum production impacts on quality of life and is a feature of many respiratory diseases. Identification of the genetic variants associated with chronic sputum production in a disease agnostic sample could improve understanding o... Read More about Genome-wide association study of chronic sputum production implicates loci involved in mucus production and infection.

Mendelian randomisation of eosinophils and other cell types in relation to lung function and disease (2022)
Journal Article
Guyatt, A., John, C., Williams, A. T., Shrine, N., Reeve, N. F., Sayers, I., …SpiroMeta consortium. (2023). Mendelian randomisation of eosinophils and other cell types in relation to lung function and disease. Thorax, 78(5), 496-503. https://doi.org/10.1136/thoraxjnl-2021-217993

Rationale Eosinophils are associated with airway inflammation in respiratory disease. Eosinophil production and survival is controlled partly by interleukin-5: anti-interleukin-5 agents reduce asthma and response correlates with baseline eosinophil c... Read More about Mendelian randomisation of eosinophils and other cell types in relation to lung function and disease.

Functional genomics of GPR126 in airway smooth muscle and bronchial epithelial cells (2021)
Journal Article
Hall, R. J., O'Loughlin, J., Billington, C. K., Thakker, D., Hall, I. P., & Sayers, I. (2021). Functional genomics of GPR126 in airway smooth muscle and bronchial epithelial cells. FASEB Journal, 35(7), Article e21300. https://doi.org/10.1096/fj.202002073R

GPR126 is an adhesion G protein-coupled receptor which lies on chromosome 6q24. Genetic variants in this region are reproducibly associated with lung function and COPD in genome wide association studies (GWAS). The aims of this study were to define t... Read More about Functional genomics of GPR126 in airway smooth muscle and bronchial epithelial cells.

A data analysis of the Chilean housing stock and the development of modelling archetypes (2019)
Journal Article
Molina, C., Kent, M., Hall, I., & Jones, B. (2020). A data analysis of the Chilean housing stock and the development of modelling archetypes. Energy and Buildings, 206, Article 109568. https://doi.org/10.1016/j.enbuild.2019.109568

Chile is a South American country experiencing greater social and economic development than the majority of its neighbours and whose economy is transitioning from developing to developed status. It is committed to reduce its greenhouse gas (GHG) emis... Read More about A data analysis of the Chilean housing stock and the development of modelling archetypes.

Setting the standard: The acceptability of kitchen ventilation for the English housing stock (2019)
Journal Article
O'Leary, C., Jones, B., Dimitroulopoulou, S., & Hall, I. P. (2019). Setting the standard: The acceptability of kitchen ventilation for the English housing stock. Building and Environment, 166, Article 106417. https://doi.org/10.1016/j.buildenv.2019.106417

Exposure to particulate matter with diameter ≤2.5 μm (PM2.5) is associated with an elevated risk of adverse health effects and cooking is a primary source of PM2.5 in non-smoking households. Therefore, it is important to investigate PM2.5 concentrati... Read More about Setting the standard: The acceptability of kitchen ventilation for the English housing stock.

Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell type and phenotype associations (2019)
Journal Article
Sakornsakolpat, P., Prokopenko, D., Lamontagne, M., Reeve, N. F., Guyatt, A. L., Jackson, V. E., …Cho, M. H. (2019). Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell type and phenotype associations. Nature Genetics, 51(3), 494–505. https://doi.org/10.1038/s41588-018-0342-2

Chronic obstructive pulmonary disease (COPD) is the leading cause of respiratory mortality worldwide. Genetic risk loci provide novel insights into disease pathogenesis. We performed a genome-wide association study in 35,735 cases and 222,076 control... Read More about Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell type and phenotype associations.

Investigating measurements of fine particle (PM2.5) emissions from the cooking of meals and mitigating exposure using a cooker hood (2019)
Journal Article
O 'Leary, C., Kluizenaar, Y., Jacobs, P., Borsboom, W., Hall, I., & Jones, B. (2019). Investigating measurements of fine particle (PM2.5) emissions from the cooking of meals and mitigating exposure using a cooker hood. Indoor Air, 29(3), 423-438. https://doi.org/10.1111/ina.12542

There is growing awareness that indoor exposure to particulate matter with diameter ≤ 2.5μm (PM2.5) is associated with an increased risk of adverse health effects. Cooking is a key indoor source of PM2.5 and an activity conducted daily in most homes.... Read More about Investigating measurements of fine particle (PM2.5) emissions from the cooking of meals and mitigating exposure using a cooker hood.

Genetic risk factors for the development of pulmonary disease identified by genome-wide association (2018)
Journal Article
Hall, R., Hall, I. P., & Sayers, I. (2018). Genetic risk factors for the development of pulmonary disease identified by genome-wide association. Respirology, 24(3), 204-214. https://doi.org/10.1111/resp.13436

Chronic respiratory diseases are a major cause of morbidity and mortality. Asthma and chronic obstructive pulmonary disease (COPD) combined affect over 500 million people worldwide. While environmental factors are important in disease progression, as... Read More about Genetic risk factors for the development of pulmonary disease identified by genome-wide association.

A Genome-Wide Association Study in Hispanics/Latinos Identifies Novel Signals for Lung Function. The Hispanic Community Health Study/Study of Latinos (2018)
Journal Article
Burkart, K. M., Sofer, T., London, S. J., Manichaikul, A., Hartwig, F. P., Yan, Q., …Barr, R. G. (2018). A Genome-Wide Association Study in Hispanics/Latinos Identifies Novel Signals for Lung Function. The Hispanic Community Health Study/Study of Latinos. American Journal of Respiratory and Critical Care Medicine, 198(2), 208-219. https://doi.org/10.1164/rccm.201707-1493OC

Rationale: Lung function and chronic obstructive pulmonary disease (COPD) are heritable traits. Genome-wide association studies (GWAS) have identified numerous pulmonary function and COPD loci, primarily in cohorts of European ancestry. Objectives:... Read More about A Genome-Wide Association Study in Hispanics/Latinos Identifies Novel Signals for Lung Function. The Hispanic Community Health Study/Study of Latinos.

Targeted inhibition of Gq signaling induces airway relaxation in mouse models of asthma (2017)
Journal Article
Matthey, M., Roberts, R., Seidinger, A., Simon, A., Schröder, R., Kuschak, M., …Wenzel, D. (in press). Targeted inhibition of Gq signaling induces airway relaxation in mouse models of asthma. Science Translational Medicine, 9(407), https://doi.org/10.1126/scitranslmed.aag2288

Obstructive lung diseases are common causes of disability and death worldwide. A hallmark feature is aberrant activation of Gq protein–dependent signaling cascades. Currently, drugs targeting single G protein (heterotrimeric guanine nucleotide–bindin... Read More about Targeted inhibition of Gq signaling induces airway relaxation in mouse models of asthma.

Age at menarche and lung function: a Mendelian randomization study (2017)
Journal Article
Gill, D., Sheehan, N. A., Wielscher, M., Shrine, N., Amaral, A. F. S., Thompson, J. R., …Minelli, C. (2017). Age at menarche and lung function: a Mendelian randomization study. European Journal of Epidemiology, 32(8), 701-710. https://doi.org/10.1007/s10654-017-0272-9

A trend towards earlier menarche in women has been associated with childhood factors (e.g. obesity) and hypothesised environmental exposures (e.g. endocrine disruptors present in household products). Observational evidence has shown detrimental effec... Read More about Age at menarche and lung function: a Mendelian randomization study.