All Outputs (145)

Changes in health in the countries of the UK and 150 English Local Authority areas 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016 (2018)
Journal Article
Steel, N., Ford, J. A., Newton, J. N., Davis, A. C. J., Vos, T., Naghavi, M., …Murray, C. J. L. (2018). Changes in health in the countries of the UK and 150 English Local Authority areas 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet, 392(10158), 1647-1661. https://doi.org/10.1016/S0140-6736%2818%2932207-4

Background
Previous studies have reported national and regional Global Burden of Disease (GBD) estimates for the UK. Because of substantial variation in health within the UK, action to improve it requires comparable estimates of disease burden and r... Read More about Changes in health in the countries of the UK and 150 English Local Authority areas 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016.

Development of a core outcome set for therapeutic clinical trials enrolling dogs with atopic dermatitis (COSCAD’18) (2018)
Journal Article
Olivry, T., Bensignor, E., Favrot, C., Griffin, C. E., Hill, P. B., Mueller, R. S., …Williams, H. C. (2018). Development of a core outcome set for therapeutic clinical trials enrolling dogs with atopic dermatitis (COSCAD’18). BMC Veterinary Research, 14, 1-8. https://doi.org/10.1186/s12917-018-1569-y

Background: For decades, the efficacy of interventions in clinical trials enrolling dogs with atopic dermatitis (AD) relied on heterogeneous evaluations of skin lesions and pruritus using unvalidated tools. Although some instruments for clinical sign... Read More about Development of a core outcome set for therapeutic clinical trials enrolling dogs with atopic dermatitis (COSCAD’18).

The development of a protocol for diagnosing hand dermatitis from photographic images (2018)
Journal Article
Parsons, V., Williams, H., English, J., Llewellyn, J., Ntani, G., & Madan, I. (2018). The development of a protocol for diagnosing hand dermatitis from photographic images. Contact Dermatitis, 79(5), 270-275. https://doi.org/10.1111/cod.13053

Background: A hand photography protocol was needed to ascertain the presence and severity of dermatitis in a trial testing the effectiveness of a behaviour change intervention to prevent hand dermatitis in nurses.
Methods: We developed the protocol... Read More about The development of a protocol for diagnosing hand dermatitis from photographic images.

What’s new in psoriasis treatment? An analysis of systematic reviews published in 2015 (2018)
Journal Article
Foulkes, A., Ferguson, F., Grindlay, D. J., Williams, H. C., Griffiths, C., & Warren, R. (2018). What’s new in psoriasis treatment? An analysis of systematic reviews published in 2015. Clinical and Experimental Dermatology, 43(7), 759-765. https://doi.org/10.1111/ced.13601

This review provides a summary of key findings from 27 systematic reviews of 51 articles first published or indexed during 2015, focusing on the treatment of psoriasis as well as precision medicine in psoriasis. Evidence supports weight loss interven... Read More about What’s new in psoriasis treatment? An analysis of systematic reviews published in 2015.

Standardized reporting of the Eczema Area and Severity Index (EASI) and the Patient-Oriented Eczema Measure (POEM): a recommendation by the Harmonising Outcome Measures for Eczema (HOME) Initiative (2018)
Journal Article
Grinich, E. E., Schmitt, J., Küster, D., Spuls, P. I., Williams, H. C., Chalmers, J. R., Thomas, K. S., Apfelbacher, C., Prinsen, C. A., Furue, M., Stuart, B., Carter, B., & Simpson, E. L. (2018). Standardized reporting of the Eczema Area and Severity Index (EASI) and the Patient-Oriented Eczema Measure (POEM): a recommendation by the Harmonising Outcome Measures for Eczema (HOME) Initiative. British Journal of Dermatology, 179(2), 540-541. https://doi.org/10.1111/bjd.16732

Emollient bath additives for the treatment of childhood eczema (BATHE): multi-centre pragmatic parallel group randomised controlled trial of clinical and cost-effectiveness (2018)
Journal Article
Santer, M., Ridd, M. J., Francis, N. A., Stuart, B., Rumsby, K., Chorozoglou, M., Becque, T., Roberts, A., Liddiard, L., Nollett, C., Hooper, J., Prude, M., Wood, W., Thomas, K. S., Thomas-Jones, E., Williams, H. C., & Little, P. (2018). Emollient bath additives for the treatment of childhood eczema (BATHE): multi-centre pragmatic parallel group randomised controlled trial of clinical and cost-effectiveness. BMJ, 361, 1-8. https://doi.org/10.1136/bmj.k1332

Objectives: To determine the clinical and cost-effectiveness of including emollient bath additives in the management of childhood eczema.
Trial design: Pragmatic randomised open-label superiority trial with two parallel groups.
Setting and recrui... Read More about Emollient bath additives for the treatment of childhood eczema (BATHE): multi-centre pragmatic parallel group randomised controlled trial of clinical and cost-effectiveness.

Interventions for preventing occupational irritant hand dermatitis (Review) (2018)
Journal Article
Bauer, A., Rönsch, H., Elsner, P., Dittmar, D., Bennett, C., Schuttelaar, M.-L. A., Lukács, J., John, S. M., & Williams, H. C. (in press). Interventions for preventing occupational irritant hand dermatitis (Review). Cochrane Database of Systematic Reviews, https://doi.org/10.1002/14651858.CD004414.pub3

Background:
Occupational irritant hand dermatitis (OIHD) causes significant functional impairment, disruption of work, and discomfort in the working population. Different preventive measures such as protective gloves, barrier creams and moisturisers... Read More about Interventions for preventing occupational irritant hand dermatitis (Review).

Report from the fifth international consensus meeting to harmonize core outcome measures for atopic eczema/dermatitis clinical trials (HOME initiative) (2018)
Journal Article
Chalmers, J., Thomas, K., Apfelbacher, C., Williams, H., Prinsen, C., Spuls, P., Simpson, E., Gerbens, L., Boers, M., Barbarot, S., Stalder, J., Abuabara, K., Aoki, V., Ardeleanu, M., Armstrong, J., Bang, B., Berents, T., Burton, T., Butler, L., Chubachi, T., …Zaniboni, M. (2018). Report from the fifth international consensus meeting to harmonize core outcome measures for atopic eczema/dermatitis clinical trials (HOME initiative). British Journal of Dermatology, 178(5), e332-e341. https://doi.org/10.1111/bjd.16543

This is the report from the fifth meeting of the Harmonising Outcome Measures for Eczema initiative (HOME V). The meeting was held on 12–14 June 2017 in Nantes, France, with 81 participants. The main aims of the meeting were (i) to achieve consensus... Read More about Report from the fifth international consensus meeting to harmonize core outcome measures for atopic eczema/dermatitis clinical trials (HOME initiative).

Home interventions and light therapy for treatment of vitiligo (HI-Light Vitiligo Trial): study protocol for a randomized controlled trial (2018)
Journal Article
Haines, R. H., Thomas, K. S., Montgomery, A. A., Ravenscroft, J. C., Akram, P., Chalmers, J., Whitman, D., Duley, L., Eleftheriadou, V., Meakin, G., Mitchell, E., White, J., Rogers, A., Sach, T., Santer, M., Tan, W., Hepburn, T., Williams, H. C., & Batchelor, J. M. (2018). Home interventions and light therapy for treatment of vitiligo (HI-Light Vitiligo Trial): study protocol for a randomized controlled trial. BMJ Open, 8(4), Article e018649. https://doi.org/10.1136/bmjopen-2017-018649

Vitiligo is a condition resulting in white patches on the skin. People with vitiligo can suffer from low self-esteem, psychological disturbance and diminished quality of life. Vitiligo is often poorly managed, partly due to lack of high quality evide... Read More about Home interventions and light therapy for treatment of vitiligo (HI-Light Vitiligo Trial): study protocol for a randomized controlled trial.

Core outcome sets in dermatology: report from the second meeting of the International Cochrane Skin Group Core Outcome Set Initiative (2018)
Journal Article
Kottner, J., Jacobi, L., Hahnel, E., Alam, M., Beeckman, D., Busard, C., Chalmers, J., Deckert, S., Eleftheriadou, V., Furlan, K., Horbach, S. E., Kirkham, J. J., Nast, A., Thiboutot, D., Thorlacius, L., Weller, K., Williams, H. C., & Schmitt, J. (2018). Core outcome sets in dermatology: report from the second meeting of the International Cochrane Skin Group Core Outcome Set Initiative. British Journal of Dermatology, 178(4), Article e279-e285. https://doi.org/10.1111/bjd.16324

Results of clinical trials are the most important information source for generating external clinical evidence. The use of different outcomes across trials, which investigate similar interventions for similar patient groups, significantly limits the... Read More about Core outcome sets in dermatology: report from the second meeting of the International Cochrane Skin Group Core Outcome Set Initiative.

Long-term management of moderate-to-severe atopic dermatitis with dupilumab and concomitant topical corticosteroids (LIBERTY AD CHRONOS): a critical appraisal (2018)
Journal Article
Thomson, J., Wernham, A., & Williams, H. C. (2018). Long-term management of moderate-to-severe atopic dermatitis with dupilumab and concomitant topical corticosteroids (LIBERTY AD CHRONOS): a critical appraisal. British Journal of Dermatology, 178(4), 897-902. https://doi.org/10.1111/bjd.16317

Aim

Blauvelt et al. (The Lancet 2017; 389: 2287-303) aimed to compare the long-term efficacy and safety of dupilumab with medium-potency topical corticosteroids (TCS) versus placebo with TCS in adults with moderate-to-severe atopic dermatitis (AD)... Read More about Long-term management of moderate-to-severe atopic dermatitis with dupilumab and concomitant topical corticosteroids (LIBERTY AD CHRONOS): a critical appraisal.

Ciclosporin compared to prednisolone therapy for patients with pyoderma gangrenosum: cost-effectiveness analysis of the STOP GAP trial (2017)
Journal Article
Mason, J., Thomas, K., Ormerod, A., Craig, F., Mitchell, E., Norrie, J., & Williams, H. (2017). Ciclosporin compared to prednisolone therapy for patients with pyoderma gangrenosum: cost-effectiveness analysis of the STOP GAP trial. British Journal of Dermatology, 177(6), 1527-1536. https://doi.org/10.1111/bjd.15561

Background

Pyoderma gangrenosum (PG) is a painful, ulcerating skin disease with poor evidence for management. Prednisolone and ciclosporin are the most commonly used treatments, although not previously compared within a randomised controlled trial... Read More about Ciclosporin compared to prednisolone therapy for patients with pyoderma gangrenosum: cost-effectiveness analysis of the STOP GAP trial.

Measuring long-term disease control in patients with atopic dermatitis: A validation study of well-controlled weeks (2017)
Journal Article
Langan, S. M., Stuart, B., Bradshaw, L., Schmitt, J., Williams, H. C., & Thomas, K. S. (2017). Measuring long-term disease control in patients with atopic dermatitis: A validation study of well-controlled weeks. Journal of Allergy and Clinical Immunology, 140(6), 1580-1586. https://doi.org/10.1016/j.jaci.2017.02.043

Background:Because atopic dermatitis (AD) is a relapsing, remitting disease, assessing long‐term control is important. Well controlled weeks (WCWs) have been used to assess asthma long‐term control, but never validated for AD.
Objectives: To assess... Read More about Measuring long-term disease control in patients with atopic dermatitis: A validation study of well-controlled weeks.

Development and validation of an algorithm to accurately identify atopic eczema patients in primary care electronic health records from the UK (2017)
Journal Article
Abuabara, K., Magyari, A., Hoffstad, O., Jabbar-Lopez, Z., Smeeth, L., Williams, H., …Langan, S. (2017). Development and validation of an algorithm to accurately identify atopic eczema patients in primary care electronic health records from the UK. Journal of Investigative Dermatology, 137(8), 1655-1662. https://doi.org/10.1016/j.jid.2017.03.029

Electronic health records hold great promise for clinical and epidemiologic research. Undertaking atopic eczema (AE) research using such data is challenging due to its episodic and heterogeneous nature. We sought to develop and validate a diagnostic... Read More about Development and validation of an algorithm to accurately identify atopic eczema patients in primary care electronic health records from the UK.

Silk garments plus standard care compared with standard care for treating eczema in children: A randomised, controlled, observer-blind, pragmatic trial (CLOTHES Trial) (2017)
Journal Article
Thomas, K. S., Bradshaw, L. E., Sach, T. H., Batchelor, J. M., Lawton, S., Harrison, E. F., …MacCallum, S. (2017). Silk garments plus standard care compared with standard care for treating eczema in children: A randomised, controlled, observer-blind, pragmatic trial (CLOTHES Trial). PLoS Medicine, 14(4), Article e1002280. https://doi.org/10.1371/journal.pmed.1002280

© 2017 Thomas et al. Background: The role of clothing in the management of eczema (also called atopic dermatitis or atopic eczema) is poorly understood. This trial evaluated the effectiveness and cost-effectiveness of silk garments (in addition to st... Read More about Silk garments plus standard care compared with standard care for treating eczema in children: A randomised, controlled, observer-blind, pragmatic trial (CLOTHES Trial).

Doxycycline versus prednisolone as an initial treatment strategy for bullous pemphigoid: a pragmatic non-inferiority randomised controlled trial (2017)
Journal Article
Williams, H. C., Wojnarowska, F., Kirtschig, G., Mason, J., Godec, T. R., Schmidt, E., Chalmers, J., Childs, M., Walton, S., Harman, K., Chapman, A., Whitham, D., & Nunn, A. J. (in press). Doxycycline versus prednisolone as an initial treatment strategy for bullous pemphigoid: a pragmatic non-inferiority randomised controlled trial. Lancet, 389(10079), https://doi.org/10.1016/S0140-6736%2817%2930560-3

Background: Bullous pemphigoid (BP) is a blistering skin disorder with increased mortality. We tested whether a strategy of starting treatment with doxycycline conveys acceptable short-term blister control whilst conferring long-term safety advantage... Read More about Doxycycline versus prednisolone as an initial treatment strategy for bullous pemphigoid: a pragmatic non-inferiority randomised controlled trial.

Surgery versus 5% imiquimod for nodular and superficial basal-cell carcinoma: five year results of the SINS randomised controlled trial (2016)
Journal Article
Williams, H. C., Bath-Hextall, F., Ozolins, M., Armstrong, S. J., Colver, G. B., Perkins, W., Miller, P. S., & Surgery versus Imiquimod forNodular and Superficial basal cell carcinoma (SINS) study group. (2017). Surgery versus 5% imiquimod for nodular and superficial basal-cell carcinoma: five year results of the SINS randomised controlled trial. Journal of Investigative Dermatology, 137(3), 614-619. https://doi.org/10.1016/j.jid.2016.10.019

Background: We previously reported modest clinical 3-year benefit for topical imiquimod compared with surgery for superficial or nodular basal cell carcinoma (sBCC, nBCC) at low risk sites in our non-inferiority randomised controlled SINS trial. Here... Read More about Surgery versus 5% imiquimod for nodular and superficial basal-cell carcinoma: five year results of the SINS randomised controlled trial.

Shared decision-making and patient decision aids in dermatology (2016)
Journal Article
Tan, J., Linos, E., Sendelweck, M. A., van Zuuren, E. J., Ersser, S., Dellavalle, R. P., & Williams, H. C. (in press). Shared decision-making and patient decision aids in dermatology. British Journal of Dermatology, 175(5), https://doi.org/10.1111/bjd.14803

Shared decision making combines individual patient interests and values with clinical best evidence under the guiding principle of patient autonomy. Patient decision aids can support shared decision making and facilitate decisions that have multiple... Read More about Shared decision-making and patient decision aids in dermatology.

What is the evidence-base for atopic eczema treatments? A summary of published randomised controlled trials (2016)
Journal Article
Nankervis, H., Thomas, K., Delamere, F. M., Barbarot, S., Smith, S., Rogers, N. K., & Williams, H. C. (in press). What is the evidence-base for atopic eczema treatments? A summary of published randomised controlled trials. British Journal of Dermatology, 176(4), https://doi.org/10.1111/bjd.14999

Atopic eczema (AE) is a common chronic inflammatory skin condition. Whilst many AE treatment options are available, the evidence to support their efficacy varies in depth and quality. In 2000, an NIHR HTA systematic review identified and evaluated ex... Read More about What is the evidence-base for atopic eczema treatments? A summary of published randomised controlled trials.

Clinical outcomes and response of patients applying topical therapy for pyoderma gangrenosum: A prospective cohort study (2016)
Journal Article
Thomas, K. S., Ormerod, A. D., Craig, F. E., Greenlaw, N., Norrie, J., Mitchell, E., …Williams, H. C. (2016). Clinical outcomes and response of patients applying topical therapy for pyoderma gangrenosum: A prospective cohort study. Journal of The American Academy of Dermatology, 75(5), 940-949. https://doi.org/10.1016/j.jaad.2016.06.016

Background: pyoderma gangrenosum (PG) is an uncommon dermatosis with a limited evidence base for treatment.

Objective: to estimate the effectiveness of topical therapies in the treatment of PG.

Methods: prospective cohort study of UK secondary... Read More about Clinical outcomes and response of patients applying topical therapy for pyoderma gangrenosum: A prospective cohort study.