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All Outputs (182)

Effectiveness and safety of lotion, cream, gel, and ointment emollients for childhood eczema: a pragmatic, randomised, phase 4, superiority trial (2022)
Journal Article
Ridd, M. J., Santer, M., MacNeill, S. J., Sanderson, E., Wells, S., Webb, D., Banks, J., Sutton, E., Roberts, A., Liddiard, L., Wilkins, Z., Clayton, J., Garfield, K., Barrett, T. J., Lane, J. A., Baxter, H., Howells, L., Taylor, J., Hay, A. D., Williams, H. C., & Thomas, K. S. (2022). Effectiveness and safety of lotion, cream, gel, and ointment emollients for childhood eczema: a pragmatic, randomised, phase 4, superiority trial. Lancet Child and Adolescent Health, 6(8), 522-532. https://doi.org/10.1016/S2352-4642%2822%2900146-8

Background: To our knowledge, there are no trials comparing emollients commonly used for childhood eczema. We aimed to compare the clinical effectiveness and safety of the four main emollient types: lotions, creams, gels, and ointments. Methods: We d... Read More about Effectiveness and safety of lotion, cream, gel, and ointment emollients for childhood eczema: a pragmatic, randomised, phase 4, superiority trial.

Incidence and pattern of mycophenolate discontinuation associated with abnormal monitoring blood-test results: cohort study using data from the Clinical Practice Research Datalink Aurum (2022)
Journal Article
Nakafero, G., Grainge, M. J., Card, T., Mallen, C. D., Riley, R., Van Der Windt, D., Fox, C. P., Taal, M. W., Aithal, G. P., Williams, H. C., & Abhishek, A. (2022). Incidence and pattern of mycophenolate discontinuation associated with abnormal monitoring blood-test results: cohort study using data from the Clinical Practice Research Datalink Aurum. Rheumatology Advances in Practice, 6(2), Article rkac046. https://doi.org/10.1093/rap/rkac046

Objective: The aim was to examine the incidence and pattern of MMF discontinuation associated with abnormal monitoring blood-test results. Methods: Data from people prescribed MMF for common inflammatory conditions in the Clinical Practice Research D... Read More about Incidence and pattern of mycophenolate discontinuation associated with abnormal monitoring blood-test results: cohort study using data from the Clinical Practice Research Datalink Aurum.

Effects of temporarily suspending low-dose methotrexate treatment for 2 weeks after SARS-CoV-2 vaccine booster on vaccine response in immunosuppressed adults with inflammatory conditions: protocol for a multicentre randomised controlled trial and nested mechanistic substudy (Vaccine Response On/Off Methotrexate (VROOM) study) (2022)
Journal Article
Abhishek, A., Boyton, R. J., McKnight, Á., Coates, L. C., Bluett, J., Barber, V., Cureton, L., Francis, A., Appelbe, D., Eldridge, L., Julier, P., Peckham, N., Valdes, A. M., Rombach, I., Altmann, D. M., Nguyen-Van-Tam, J., Williams, H. C., & Cook, J. A. (2022). Effects of temporarily suspending low-dose methotrexate treatment for 2 weeks after SARS-CoV-2 vaccine booster on vaccine response in immunosuppressed adults with inflammatory conditions: protocol for a multicentre randomised controlled trial and nested mechanistic substudy (Vaccine Response On/Off Methotrexate (VROOM) study). BMJ Open, 12(5), Article e062599. https://doi.org/10.1136/bmjopen-2022-062599

Introduction It is unknown if a temporary break in long-term immune-suppressive treatment after vaccination against COVID-19 improves vaccine response. The objective of this study was to evaluate if a 2-week interruption in low-dose weekly methotrexa... Read More about Effects of temporarily suspending low-dose methotrexate treatment for 2 weeks after SARS-CoV-2 vaccine booster on vaccine response in immunosuppressed adults with inflammatory conditions: protocol for a multicentre randomised controlled trial and nested mechanistic substudy (Vaccine Response On/Off Methotrexate (VROOM) study).

Eczema Care Online: development and qualitative optimisation of an online behavioural intervention to support self-management in young people with eczema (2022)
Journal Article
Greenwell, K., Ghio, D., Sivyer, K., Steele, M., Teasdale, E., Ridd, M. J., Roberts, A., Chalmers, J. R., Lawton, S., Langan, S., Cowdell, F., Le Roux, E., Wilczynska, S., Jones, H., Whittaker, E., Williams, H. C., Thomas, K. S., Yardley, L., Santer, M., & Muller, I. (2022). Eczema Care Online: development and qualitative optimisation of an online behavioural intervention to support self-management in young people with eczema. BMJ Open, 12(4), Article e056867. https://doi.org/10.1136/bmjopen-2021-056867

Objectives To describe the development of Eczema Care Online (ECO), an online behaviour change intervention for young people with eczema (phase I); and explore and optimise the acceptability of ECO among this target group using think-aloud interviews... Read More about Eczema Care Online: development and qualitative optimisation of an online behavioural intervention to support self-management in young people with eczema.

Celebrating 20 years of the UK Dermatology Clinical Trials Network. Part 2: education, training and capacity building (2022)
Journal Article
Layfield, C. P., Williams, H. C., & The UK Dermatology Clinical Trials Network. (2022). Celebrating 20 years of the UK Dermatology Clinical Trials Network. Part 2: education, training and capacity building. Clinical and Experimental Dermatology, 47(6), 1060-1067. https://doi.org/10.1111/ced.15132

In Part 1 of this 2-part review of the 20th anniversary of the UK Dermatology Clinical Trials Network (UK DCTN), we described its role in developing and supporting clinical trial proposals, elaborating on structure, process and clinical trials activi... Read More about Celebrating 20 years of the UK Dermatology Clinical Trials Network. Part 2: education, training and capacity building.

Avoidable research waste in dermatology: what are the solutions? (2022)
Journal Article
Williams, H. C. (2022). Avoidable research waste in dermatology: what are the solutions?. British Journal of Dermatology, 186(4), 599-601. https://doi.org/10.1111/bjd.20755

In the last editorial, I provided examples of research waste in dermatology and suggested that it was due to a system failure rather than just a few “bad apples”. Here, I focus on possible solutions, mainly in relation to clinical trials, building on... Read More about Avoidable research waste in dermatology: what are the solutions?.

Avoidable research waste in dermatology: what are the solutions? (2022)
Journal Article
Williams, H. C. (2022). Avoidable research waste in dermatology: what are the solutions?. British Journal of Dermatology, 186(4), 599-601. https://doi.org/10.1111/bjd.20755

In the last editorial, I provided examples of research waste in dermatology and suggested that it was due to a system failure rather than just a few “bad apples”. Here, I focus on possible solutions, mainly in relation to clinical trials, building on... Read More about Avoidable research waste in dermatology: what are the solutions?.

The HOME Core outcome set for clinical trials of atopic dermatitis (2022)
Journal Article
Williams, H. C., Schmitt, J., Thomas, K. S., Spuls, P. I., Simpson, E. L., Apfelbacher, C. J., Chalmers, J. R., Furue, M., Katoh, N., Gerbens, L. A., Leshem, Y. A., Howells, L., Singh, J. A., & Boers, M. (2022). The HOME Core outcome set for clinical trials of atopic dermatitis. Journal of Allergy and Clinical Immunology, 149(6), 1899-1911. https://doi.org/10.1016/j.jaci.2022.03.017

Core outcome sets are critically important outcomes that should be measured in clinical trials. Their absence in atopic dermatitis is a form of research waste and impedes combining evidence to inform patient care. Here, we articulate the rationale fo... Read More about The HOME Core outcome set for clinical trials of atopic dermatitis.

Classifying atopic dermatitis: a systematic review of phenotypes and associated characteristics (2022)
Journal Article
Bosma, A. L., Ascott, A., Iskandar, R., Farquhar, K., Matthewman, J., Langendam, M. W., Mulick, A., Abuabara, K., Williams, H. C., Spuls, P. I., Langan, S. M., & Middelkamp-Hup, M. A. (2022). Classifying atopic dermatitis: a systematic review of phenotypes and associated characteristics. Journal of the European Academy of Dermatology and Venereology, 36(6), 807-819. https://doi.org/10.1111/jdv.18008

Atopic dermatitis is a heterogeneous disease, accompanied by a wide variation in disease presentation and the potential to identify many phenotypes that may be relevant for prognosis and treatment. We aimed to systematically review previously reporte... Read More about Classifying atopic dermatitis: a systematic review of phenotypes and associated characteristics.

Celebrating 20 years of the UK Dermatology Clinical Trials Network. Part 1: Developing and delivering high-quality independent clinical trials (2022)
Journal Article
Williams, H. C., McPhee, M., Layfield, C., & The UK Dermatology Clinical Trials Network. (2022). Celebrating 20 years of the UK Dermatology Clinical Trials Network. Part 1: Developing and delivering high-quality independent clinical trials. Clinical and Experimental Dermatology, 47(6), 1048-1059. https://doi.org/10.1111/ced.15140

The UK Dermatology Clinical Trials Network (UK DCTN) was formed in 2002 with the aim of developing and supporting high-quality independent national clinical trials that address prioritized research questions for people with skin disease. Its philosop... Read More about Celebrating 20 years of the UK Dermatology Clinical Trials Network. Part 1: Developing and delivering high-quality independent clinical trials.

Response to ‘The role of curettage as an intervention for basal cell carcinoma’. Re. ‘Interventions for basal cell carcinoma: abridged Cochrane systematic review and GRADE assessments’: reply from the authors (2021)
Journal Article
Bath-Hextall, F. J., Thomson, J., Hogan, S., Leonardi-Bee, J., Williams, H. C., & Bath‐Hextall, F. (2022). Response to ‘The role of curettage as an intervention for basal cell carcinoma’. Re. ‘Interventions for basal cell carcinoma: abridged Cochrane systematic review and GRADE assessments’: reply from the authors. British Journal of Dermatology, 186(4), 751-752. https://doi.org/10.1111/bjd.20950

Clinical examination for hyperlinear palms to determine filaggrin genotype: A diagnostic test accuracy study (2021)
Journal Article
Bradshaw, L. E., Haines, R. H., Thomas, K. S., Chalmers, J. R., Irvine, A. D., Williams, H. C., & Brown, S. J. (2021). Clinical examination for hyperlinear palms to determine filaggrin genotype: A diagnostic test accuracy study. Clinical and Experimental Allergy, 51(11), 1421-1428. https://doi.org/10.1111/cea.14025

Background: Palmar hyperlinearity is a feature of ichthyosis vulgaris, the monogenic skin disorder caused by FLG loss-of-function mutations. Objective: To investigate how well the presence or absence of hyperlinear palms (HLP) detect FLG genotype in... Read More about Clinical examination for hyperlinear palms to determine filaggrin genotype: A diagnostic test accuracy study.

Patterns of Atopic Eczema Disease Activity from Birth through Midlife in 2 British Birth Cohorts (2021)
Journal Article
Abuabara, K., Ye, M., Margolis, D. J., Mcculloch, C. E., Mulick, A. R., Silverwood, R. J., Sullivan, A., Williams, H. C., & Langan, S. M. (2021). Patterns of Atopic Eczema Disease Activity from Birth through Midlife in 2 British Birth Cohorts. JAMA Dermatology, 157(10), 1191-1199. https://doi.org/10.1001/jamadermatol.2021.2489

Importance: Atopic eczema is characterized by a heterogenous waxing and waning course, with variable age of onset and persistence of symptoms. Distinct patterns of disease activity such as early-onset/resolving and persistent disease have been identi... Read More about Patterns of Atopic Eczema Disease Activity from Birth through Midlife in 2 British Birth Cohorts.

Safety of topical corticosteroids in atopic eczema: an umbrella review (2021)
Journal Article
Axon, E., Chalmers, J. R., Santer, M., Ridd, M. J., Lawton, S., Langan, S. M., Grindlay, D. J., Muller, I., Roberts, A., Ahmed, A., Williams, H. C., & Thomas, K. S. (2021). Safety of topical corticosteroids in atopic eczema: an umbrella review. BMJ Open, 11(7), Article e046476. https://doi.org/10.1136/bmjopen-2020-046476

Objective An umbrella review summarising all safety data from systematic reviews of topical corticosteroids (TCS) in adults and children with atopic eczema. Methods Embase, MEDLINE, PubMed, Cochrane Database of Systematic Reviews and the Centre of Ev... Read More about Safety of topical corticosteroids in atopic eczema: an umbrella review.

Realising the full potential of data-enabled trials in the UK: a call for action (2021)
Journal Article
Sydes, M. R., Barbachano, Y., Bowman, L., Denwood, T., Farmer, A., Garfield-Birkbeck, S., Gibson, M., Gulliford, M. C., Harrison, D. A., Hewitt, C., Logue, J., Navaie, W., Norrie, J., O’Kane, M., Quint, J. K., Rycroft-Malone, J., Sheffield, J., Smeeth, L., Sullivan, F., Tizzard, J., …Valentine, J. (2021). Realising the full potential of data-enabled trials in the UK: a call for action. BMJ Open, 11(6), 1-15. https://doi.org/10.1136/bmjopen-2020-043906

Rationale: Clinical trials are the gold standard for testing interventions. COVID-19 has further raised their public profile, and emphasised the need to deliver better, faster, more efficient trials for patient benefit. Considerable overlap exists be... Read More about Realising the full potential of data-enabled trials in the UK: a call for action.