Skip to main content

Research Repository

Advanced Search

All Outputs (28)

Cochrane reviews and dermatological trials outcome concordance: why Core Outcome Sets could make trial results more usable (2018)
Journal Article
Schmitt, J., Lange, T., Kottner, J., Prinsen, C. A. C., Weberschock, T., Hahnel, E., …Cochrane Skin Core Outcome Set Initiative (CS-COUSIN). (2019). Cochrane reviews and dermatological trials outcome concordance: why Core Outcome Sets could make trial results more usable. Journal of Investigative Dermatology, 139(5), 1045-1053. https://doi.org/10.1016/j.jid.2018.11.019

Evidence-based healthcare requires that relevant outcomes for patients are included in clinical trials which investigating treatment effects allowing subsequent systematic reviews to summarize all relevant evidence to guide clinical practice. Current... Read More about Cochrane reviews and dermatological trials outcome concordance: why Core Outcome Sets could make trial results more usable.

Optical coherence tomography for the diagnosis of skin cancer in adults (2018)
Journal Article
Ferrante di Ruffano, L., Dinnes, J., Deeks, J. J., Chuchu, N., Bayliss, S. E., Davenport, C., Takwoingi, Y., Godfrey, K., O'Sullivan, C., Matin, R. N., Tehrani, H., & Williams, H. C. (2018). Optical coherence tomography for the diagnosis of skin cancer in adults. Cochrane Database of Systematic Reviews, 2018(12), https://doi.org/10.1002/14651858.CD013189

Background:
Early accurate detection of all skin cancer types is essential to guide appropriate management and to improve morbidity and survival. Melanoma and squamous cell carcinoma (SCC) are high-risk skin cancers, which have the potential to meta... Read More about Optical coherence tomography for the diagnosis of skin cancer in adults.

Are environmental factors for atopic eczema in ISAAC Phase Three due to reverse causation? (2018)
Journal Article
Rutter, C., Silverwood, R. J., Williams, H. C., Elwood, P., Asher, I., Garcia-Marcos, L., …ISAAC Phase Three Group. (2019). Are environmental factors for atopic eczema in ISAAC Phase Three due to reverse causation?. Journal of Investigative Dermatology, 139(5), 1023-1036. https://doi.org/10.1016/j.jid.2018.08.035

Some previously described environmental associations for atopic eczema (AE) may be due to reverse causation. We explored the role of reverse causation by comparing individual- and school-level results for multiple AE risk factors.

ISAAC Phase Thre... Read More about Are environmental factors for atopic eczema in ISAAC Phase Three due to reverse causation?.

Computer assisted diagnosis techniques (dermoscopy and spectroscopy-based) for diagnosing skin cancer in adults (2018)
Journal Article
Ferrante di Ruffano, L., Takwoingi, Y., Dinnes, J., Chuchu, N., Bayliss, S. E., Davenport, C., Matin, R. N., Godfrey, K., O'Sullivan, C., Gulati, A., Chan, S. A., Durack, A., O'Connell, S., Gardiner, M. D., Bamber, J., Deeks, J. J., & Williams, H. C. (2018). Computer assisted diagnosis techniques (dermoscopy and spectroscopy-based) for diagnosing skin cancer in adults. Cochrane Database of Systematic Reviews, 2018(12), Article CD013186. https://doi.org/10.1002/14651858.CD013186

Background: Early accurate detection of all skin cancer types is essential to guide appropriate management and to improve morbidity and survival. Melanoma and cutaneous squamous cell carcinoma (cSCC) are high‐risk skin cancers which have the potentia... Read More about Computer assisted diagnosis techniques (dermoscopy and spectroscopy-based) for diagnosing skin cancer in adults.

Reflectance confocal microscopy for diagnosising keratinocyte skin cancers in adults (2018)
Journal Article
Dinnes, J., Deeks, J. J., Chuchu, N., Saleh, D., Bayliss, S. E., Takwoingi, Y., Davenport, C., Patel, L., Matin, R. N., O'Sullivan, C., Patalay, R., & Williams, H. C. (2018). Reflectance confocal microscopy for diagnosising keratinocyte skin cancers in adults. Cochrane Database of Systematic Reviews, 2018(12), 1-154. https://doi.org/10.1002/14651858.CD013191

Background
Early accurate detection of all skin cancer types is important to guide appropriate management and to improve morbidity and survival. Basal cell carcinoma (BCC) is usually a localised skin cancer but with potential to infiltrate and damag... Read More about Reflectance confocal microscopy for diagnosising keratinocyte skin cancers in adults.

High frequency ultrasound for the diagnosis of skin cancer in adults (2018)
Journal Article
Dinnes, J., Bamber, J., Chuchu, N., Bayliss, S. E., Takwoingi, Y., Davenport, C., Godfrey, K., O'Sullivan, C., Matin, R. N., Deeks, J. J., & Williams, H. C. (2018). High frequency ultrasound for the diagnosis of skin cancer in adults. Cochrane Database of Systematic Reviews, 2018(12), Article CD013188. https://doi.org/10.1002/14651858.CD013188

Background: Early accurate detection of all skin cancer types is essential to guide appropriate management and to improve morbidity and survival. Melanoma and squamous cell carcinoma (SCC) are high risk skin cancers which have the potential to metast... Read More about High frequency ultrasound for the diagnosis of skin cancer in adults.

Reflectance confocal microscopy for diagnosing cutaneous melanoma in adults (2018)
Journal Article
Dinnes, J., Deeks, J. J., Saleh, D., Chuchu, N., Bayliss, S. E., Patel, L., Davenport, C., Takwoingi, Y., Godfrey, K., Matin, R. N., Patalay, R., & Williams, H. C. (2018). Reflectance confocal microscopy for diagnosing cutaneous melanoma in adults. Cochrane Database of Systematic Reviews, 2018(12), Article CD013190. https://doi.org/10.1002/14651858.CD013190

Background: Melanoma has one of the fastest rising incidence rates of any cancer. It accounts for a small percentage of skin cancer cases but is responsible for the majority of skin cancer deaths. Early detection and treatment is key to improving sur... Read More about Reflectance confocal microscopy for diagnosing cutaneous melanoma in adults.

Visual inspection for the diagnosis of cutaneous melanoma in adults (2018)
Journal Article
Dinnes, J., Deeks, J. J., Grainge, M. J., Chuchu, N., Ferrante di Ruffano, L., Matin, R. N., Thomson, D. R., Wong, K. Y., Aldridge, R. B., Abbott, R., Fawzy, M., Bayliss, S. E., Takwoingi, Y., Davenport, C., Godfrey, K., Walter, F. M., & Williams, H. C. (2018). Visual inspection for the diagnosis of cutaneous melanoma in adults. Cochrane Database of Systematic Reviews, 2018(12), Article CD013194. https://doi.org/10.1002/14651858.CD013194

Background: Melanoma has one of the fastest rising incidence rates of any cancer. It accounts for a small percentage of skin cancer cases but is responsible for the majority of skin cancer deaths. History-taking and visual inspection of a suspicious... Read More about Visual inspection for the diagnosis of cutaneous melanoma in adults.

Smartphone applications for triaging adults with skin lesions that are suspicious for melanoma (2018)
Journal Article
Chuchu, N., Takwoingi, Y., Dinnes, J., Matin, R. N., Bassett, O., Moreau, J. F., …Williams, H. C. (2018). Smartphone applications for triaging adults with skin lesions that are suspicious for melanoma. Cochrane Database of Systematic Reviews, 2018(12), Article CD013192. https://doi.org/10.1002/14651858.CD013192

Background: Melanoma accounts for a small proportion of all skin cancer cases but is responsible for the majority of skin cancer-related deaths. Early detection and treatment can improve survival. Smartphone applications are readily accessible and po... Read More about Smartphone applications for triaging adults with skin lesions that are suspicious for melanoma.

Visual inspection and dermoscopy, alone or in combination, for diagnosing keratinocyte skin cancers in adults (2018)
Journal Article
Dinnes, J., Deeks, J. J., Chuchu, N., Matin, R. N., Wong, K. Y., Aldridge, R. B., Durack, A., Gulati, A., Chan, S. A., Johnston, L., Bayliss, S. E., Leonardi-Bee, J. O., Takwoingi, Y., Davenport, C., O'sullivan, C., Tehrani, H., & Williams, H. C. (2018). Visual inspection and dermoscopy, alone or in combination, for diagnosing keratinocyte skin cancers in adults. Cochrane Database of Systematic Reviews, 2018(12), Article CD011901. https://doi.org/10.1002/14651858.CD011901.pub2

© 2018 The Cochrane Collaboration. Background: Early accurate detection of all skin cancer types is important to guide appropriate management, to reduce morbidity and to improve survival. Basal cell carcinoma (BCC) is almost always a localised skin c... Read More about Visual inspection and dermoscopy, alone or in combination, for diagnosing keratinocyte skin cancers in adults.

Exfoliative cytology for the diagnosis of basal cell carcinoma and other skin cancers in adults (2018)
Journal Article
Ferrante di Ruffano, L., Dinnes, J., Chuchu, N., Bayliss, S. E., Takwoingi, Y., Davenport, C., Matin, R. N., O'Sullivan, C., Roskell, D., Deeks, J. J., & Williams, H. C. (2018). Exfoliative cytology for the diagnosis of basal cell carcinoma and other skin cancers in adults. Cochrane Database of Systematic Reviews, 2018(12), Article CD013187. https://doi.org/10.1002/14651858.CD013187

Background: Early accurate detection of all skin cancer types is essential to guide appropriate management and to reduce morbidity and improve survival. Basal cell carcinoma (BCC) is usually localised to the skin with potential to infiltrate and dama... Read More about Exfoliative cytology for the diagnosis of basal cell carcinoma and other skin cancers in adults.

Teledermatology for the diagnosis of skin cancer in adults (2018)
Journal Article
Chuchu, N., Dinnes, J., Takwoingi, Y., Matin, R. N., Bayliss, S. E., Davenport, C., Moreau, J. F., Bassett, O., Godfrey, K., O'Sullivan, C., Walter, F. M., Motley, R., Deeks, J. J., & Williams, H. C. (2018). Teledermatology for the diagnosis of skin cancer in adults. Cochrane Database of Systematic Reviews, 2018(12), Article CD013193. https://doi.org/10.1002/14651858.CD013193

Background: Early accurate detection of all skin cancer types is essential to guide appropriate management and to improve morbidity and survival. Melanoma and squamous cell carcinoma (SCC) are high risk skin cancers which have the potential to metast... Read More about Teledermatology for the diagnosis of skin cancer in adults.

Dermoscopy, with and without visual inspection, for the diagnosis of melanoma in adults (2018)
Journal Article
Dinnes, J., Deeks, J. J., Chuchu, N., Ferrante di Ruffano, L., Matin, R. N., Thomson, D. R., Wong, K. Y., Aldridge, R. B., Abbott, R., Fawzy, M., Bayliss, S. E., Grainge, M. J., Takwoingi, Y., Davenport, C., Godfrey, K., Walter, F. M., & Williams, H. C. (2018). Dermoscopy, with and without visual inspection, for the diagnosis of melanoma in adults. Cochrane Database of Systematic Reviews, 2018(12), Article CD011902. https://doi.org/10.1002/14651858.CD011902.pub2

Background: Melanoma has one of the fastest rising incidence rates of any cancer. It accounts for a small percentage of skin cancer cases but is responsible for the majority of skin cancer deaths. Although history-taking and visual inspection of a su... Read More about Dermoscopy, with and without visual inspection, for the diagnosis of melanoma in adults.

Early aggressive intervention for infantile atopic dermatitis to prevent development of food allergy: a multicenter, investigator-blinded, randomized, parallel group controlled trial (PACI Study): protocol for a randomized controlled trial (2018)
Journal Article
Yamamoto-Hanada, K., Kobayashi, T., Williams, H. C., Mikami, M., Saito-Abe, M., Morita, K., …Ohya, Y. (2018). Early aggressive intervention for infantile atopic dermatitis to prevent development of food allergy: a multicenter, investigator-blinded, randomized, parallel group controlled trial (PACI Study): protocol for a randomized controlled trial. Clinical and Translational Allergy, 8, Article 47. https://doi.org/10.1186/s13601-018-0233-8

Background: Atopic dermatitis is the first clinical manifestation of the atopic march, with the highest incidence in the first year of life. Those affected often go on to develop other allergic diseases including food allergy, asthma, and allergic rh... Read More about Early aggressive intervention for infantile atopic dermatitis to prevent development of food allergy: a multicenter, investigator-blinded, randomized, parallel group controlled trial (PACI Study): protocol for a randomized controlled trial.

Adding emollient bath additives to standard eczema management for children with eczema: the BATHE RCT (2018)
Journal Article
Santer, M., Rumsby, K., Ridd, M. J., Francis, N. A., Stuart, B., Chorozoglou, M., …Little, P. (2018). Adding emollient bath additives to standard eczema management for children with eczema: the BATHE RCT. Health Technology Assessment, 22(57), 1-116. https://doi.org/10.3310/hta22570

Plain English Summary
Eczema is very common in children and can have a significant impact, causing itching and sleep problems. The main treatments are emollients, which are used to moisturise the skin, and steroid creams or ointments to treat flare-... Read More about Adding emollient bath additives to standard eczema management for children with eczema: the BATHE RCT.

Feasibility of weekly participant‐reported data collection in a pragmatic randomised controlled trial in primary care: experiences from the BATHE trial (Bath Additives for the Treatment of cHildhood Eczema) (2018)
Journal Article
Stuart, B., Rumsby, K., Santer, M., Ridd, M. J., Francis, N. A., Chorozoglou, M., …Little, P. (2018). Feasibility of weekly participant‐reported data collection in a pragmatic randomised controlled trial in primary care: experiences from the BATHE trial (Bath Additives for the Treatment of cHildhood Eczema). Trials, 19, Article 582. https://doi.org/10.1186/s13063-018-2962-3

Background: Patient‐reported outcomes measures in clinical trials ensure that evaluations of effectiveness focus on outcomes that are important to patients. In relapsing‐remitting conditions such as eczema, repeated measurements may allow a more accu... Read More about Feasibility of weekly participant‐reported data collection in a pragmatic randomised controlled trial in primary care: experiences from the BATHE trial (Bath Additives for the Treatment of cHildhood Eczema).

Changes in health in the countries of the UK and 150 English Local Authority areas 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016 (2018)
Journal Article
Steel, N., Ford, J. A., Newton, J. N., Davis, A. C. J., Vos, T., Naghavi, M., …Murray, C. J. L. (2018). Changes in health in the countries of the UK and 150 English Local Authority areas 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet, 392(10158), 1647-1661. https://doi.org/10.1016/S0140-6736%2818%2932207-4

Background
Previous studies have reported national and regional Global Burden of Disease (GBD) estimates for the UK. Because of substantial variation in health within the UK, action to improve it requires comparable estimates of disease burden and r... Read More about Changes in health in the countries of the UK and 150 English Local Authority areas 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016.

Development of a core outcome set for therapeutic clinical trials enrolling dogs with atopic dermatitis (COSCAD’18) (2018)
Journal Article
Olivry, T., Bensignor, E., Favrot, C., Griffin, C. E., Hill, P. B., Mueller, R. S., …Williams, H. C. (2018). Development of a core outcome set for therapeutic clinical trials enrolling dogs with atopic dermatitis (COSCAD’18). BMC Veterinary Research, 14, 1-8. https://doi.org/10.1186/s12917-018-1569-y

Background: For decades, the efficacy of interventions in clinical trials enrolling dogs with atopic dermatitis (AD) relied on heterogeneous evaluations of skin lesions and pruritus using unvalidated tools. Although some instruments for clinical sign... Read More about Development of a core outcome set for therapeutic clinical trials enrolling dogs with atopic dermatitis (COSCAD’18).

The development of a protocol for diagnosing hand dermatitis from photographic images (2018)
Journal Article
Parsons, V., Williams, H., English, J., Llewellyn, J., Ntani, G., & Madan, I. (2018). The development of a protocol for diagnosing hand dermatitis from photographic images. Contact Dermatitis, 79(5), 270-275. https://doi.org/10.1111/cod.13053

Background: A hand photography protocol was needed to ascertain the presence and severity of dermatitis in a trial testing the effectiveness of a behaviour change intervention to prevent hand dermatitis in nurses.
Methods: We developed the protocol... Read More about The development of a protocol for diagnosing hand dermatitis from photographic images.