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All Outputs (7)

Control of NFAT Isoform Activation and NFAT-Dependent Gene Expression through Two Coincident and Spatially Segregated Intracellular Ca 2+ Signals (2016)
Journal Article
Kar, P., Mirams, G. R., Christian, H. C., & Parekh, A. B. (2016). Control of NFAT Isoform Activation and NFAT-Dependent Gene Expression through Two Coincident and Spatially Segregated Intracellular Ca 2+ Signals. Molecular Cell, 64(4), 746-759. https://doi.org/10.1016/j.molcel.2016.11.011

© 2016 The Author(s) Excitation-transcription coupling, linking stimulation at the cell surface to changes in nuclear gene expression, is conserved throughout eukaryotes. How closely related coexpressed transcription factors are differentially activa... Read More about Control of NFAT Isoform Activation and NFAT-Dependent Gene Expression through Two Coincident and Spatially Segregated Intracellular Ca 2+ Signals.

Computational cardiology and risk stratification for sudden cardiac death: one of the grand challenges for cardiology in the 21st century (2016)
Journal Article
Hill, A. P., Perry, M. D., Abi-Gerges, N., Couderc, J.-P., Fermini, B., Hancox, J. C., Knollmann, B. C., Mirams, G. R., Skinner, J., Zareba, W., & Vandenberg, J. I. (2016). Computational cardiology and risk stratification for sudden cardiac death: one of the grand challenges for cardiology in the 21st century. Journal of Physiology, 594(23), 6893-6908. https://doi.org/10.1113/jp272015

Connexin43 contributes to electrotonic conduction across scar tissue in the intact heart (2016)
Journal Article
Mahoney, V., Mezzano, V., Mirams, G., Maass, K., Li, Z., Cerrone, M., Vasquez, C., Bapat, A., Delmar, M., & Morley, G. (2016). Connexin43 contributes to electrotonic conduction across scar tissue in the intact heart. Scientific Reports, 6(1), Article 26744. https://doi.org/10.1038/srep26744

Studies have demonstrated non-myocytes, including fibroblasts, can electrically couple to myocytes in culture. However, evidence demonstrating current can passively spread across scar tissue in the intact heart remains elusive. We hypothesize electro... Read More about Connexin43 contributes to electrotonic conduction across scar tissue in the intact heart.

Hierarchical Bayesian modelling of variability and uncertainty in synthetic action potential traces (2016)
Presentation / Conference Contribution
Johnstone, R. H., Bardenet, R., Gavaghan, D. J., Polonchuk, L., Davies, M. R., & Mirams, G. R. Hierarchical Bayesian modelling of variability and uncertainty in synthetic action potential traces. Presented at 2016 Computing in Cardiology Conference (CinC), Vancouver, BC, Canada

© 2016 CCAL. There are many sources of uncertainty in the recording and modelling of membrane action potentials (APs) from cardiomyocytes. For example, there are measurement, parameter, and model uncertainties. There is also extrinsic variability bet... Read More about Hierarchical Bayesian modelling of variability and uncertainty in synthetic action potential traces.