All Outputs (4)

A hybrid approach to multi-scale modelling of cancer (2010)
Journal Article
Osborne, J. M., Walter, A., Kershaw, S. K., Mirams, G. R., Fletcher, A. G., Pathmanathan, P., Gavaghan, D., Jensen, O. E., Maini, P. K., & Byrne, H. M. (2010). A hybrid approach to multi-scale modelling of cancer. Philosophical Transactions A: Mathematical, Physical and Engineering Sciences, 368(1930), 5013-5028. https://doi.org/10.1098/rsta.2010.0173

In this paper, we review multi-scale models of solid tumour growth and discuss a middleout framework that tracks individual cells. By focusing on the cellular dynamics of a healthy colorectal crypt and its invasion by mutant, cancerous cells, we comp... Read More about A hybrid approach to multi-scale modelling of cancer.

Phenomenological modeling of cell-to-cell and beat-to-beat variability in isolated guinea pig ventricular myocytes (2010)
Presentation / Conference Contribution
Walmsley, J., Mirams, G., Bahoshy, M., Bollensdorff, C., Rodriguez, B., & Burrage, K. (2010, August). Phenomenological modeling of cell-to-cell and beat-to-beat variability in isolated guinea pig ventricular myocytes. Presented at 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10, Buenos Aires, Argentina

Experimental action potential (AP) recordings in isolated ventricular myoctes display significant temporal beatto- beat variability in morphology and duration. Furthermore, significant cell-to-cell differences in AP also exist even for isolated cells... Read More about Phenomenological modeling of cell-to-cell and beat-to-beat variability in isolated guinea pig ventricular myocytes.

Modelling spatially regulated β-catenin dynamics and invasion in intestinal crypts (2010)
Journal Article
Murray, P. J., Kang, J. W., Mirams, G. R., Shin, S. Y., Byrne, H. M., Maini, P. K., & Cho, K. H. (2010). Modelling spatially regulated β-catenin dynamics and invasion in intestinal crypts. Biophysical Journal, 99(3), 716-725. https://doi.org/10.1016/j.bpj.2010.05.016

Experimental data (e.g., genetic lineage and cell population studies) on intestinal crypts reveal that regulatory features of crypt behavior, such as control via morphogen gradients, are remarkably well conserved among numerous organisms (e.g., from... Read More about Modelling spatially regulated β-catenin dynamics and invasion in intestinal crypts.

Multiscale modeling of colonic crypts and early colorectal cancer (2010)
Book Chapter
Fletcher, A. G., Mirams, G. R., Murray, P. J., Walter, A., Kang, J. W., Cho, K. H., Maini, P. K., & Byrne, H. M. (2010). Multiscale modeling of colonic crypts and early colorectal cancer. In T. S. Deisboeck, & G. Stamatakos (Eds.), Multiscale Cancer Modeling (111-131). CRC Press. https://doi.org/10.1201/b10407

© 2011 by Taylor & Francis Group, LLC. Colorectal cancer accounts for 13% of all cancers in the United Kingdom, with around 35,300 new diagnoses and 16,000 deaths occurring each year (http://info.cancerresearchuk.org). Colorectal cancer is predomin... Read More about Multiscale modeling of colonic crypts and early colorectal cancer.