All Outputs (6)

Representation of multiple cellular phenotypes within tissue-level simulations of cardiac electrophysiology (2018)
Journal Article
Bowler, L. A., Gavaghan, D. J., Mirams, G. R., & Whiteley, J. P. (2019). Representation of multiple cellular phenotypes within tissue-level simulations of cardiac electrophysiology. Bulletin of Mathematical Biology, 81(1), 7–38. https://doi.org/10.1007/s11538-018-0516-1

Distinct electrophysiological phenotypes are exhibited 1 by biological cells that have differentiated into particular cell types. The usual approach when simulating the cardiac electrophysiology of tissue that includes different cell types is to mode... Read More about Representation of multiple cellular phenotypes within tissue-level simulations of cardiac electrophysiology.

Assessment of an in silico mechanistic model for proarrhythmia risk prediction under the CiPA initiative (2018)
Journal Article
Li, Z., Wu, W. W., Sheng, J., Tran, P. N., Wu, M., Ranolph, A., …Strauss, D. G. (2019). Assessment of an in silico mechanistic model for proarrhythmia risk prediction under the CiPA initiative. Clinical Pharmacology and Therapeutics, 105(2), 466-475. https://doi.org/10.1002/cpt.1184

International Council on Harmonization S7B and E14 regulatory guidelines are sensitive but not specific for predicting which drugs are proarrhythmic. In response, the Comprehensive In Vitro Proarrhythmia Assay (CiPA) was proposed that integrates mult... Read More about Assessment of an in silico mechanistic model for proarrhythmia risk prediction under the CiPA initiative.

Reproducible model development in the Cardiac Electrophysiology Web Lab (2018)
Journal Article
Daly, A. C., Clerx, M., Beattie, K. A., Cooper, J., Gavaghan, D. J., & Mirams, G. R. (2018). Reproducible model development in the Cardiac Electrophysiology Web Lab. Progress in Biophysics and Molecular Biology, 139, 3-14. https://doi.org/10.1016/j.pbiomolbio.2018.05.011

The modelling of the electrophysiology of cardiac cells is one of the most mature areas of systems biology. This extended concentration of research effort brings with it new challenges, foremost among which is that of choosing which of these models i... Read More about Reproducible model development in the Cardiac Electrophysiology Web Lab.

Gaussian process emulation for discontinuous response surfaces with applications for cardiac electrophysiology models (2018)
Other
Ghosh, S., J. Gavaghan, D., & R. Mirams, G. Gaussian process emulation for discontinuous response surfaces with applications for cardiac electrophysiology models

Mathematical models of biological systems are beginning to be used for safety-critical applications, where large numbers of repeated model evaluations are required to perform uncertainty quantification and sensitivity analysis. Most of these models a... Read More about Gaussian process emulation for discontinuous response surfaces with applications for cardiac electrophysiology models.

Sinusoidal voltage protocols for rapid characterisation of ion channel kinetics (2018)
Journal Article
Beattie, K., Hill, A. P., Bardenet, R., Cui, Y., Vandenberg, J. I., Gavaghan, D. J., de Boer, T. P., & Mirams, G. R. (2018). Sinusoidal voltage protocols for rapid characterisation of ion channel kinetics. Journal of Physiology, 596(10), 1813-1828. https://doi.org/10.1113/JP275733

Understanding the roles of ion currents is crucial to predict the action of pharmaceuticals and mutations in different scenarios, and thereby to guide clinical interventions in the heart, brain and other electrophysiological systems. Our ability to p... Read More about Sinusoidal voltage protocols for rapid characterisation of ion channel kinetics.

Sequential forward and reverse transport of the Na+ Ca2+ exchanger generates Ca2+ oscillations within mitochondria (2018)
Journal Article
Samanta, K., Mirams, G. R., & Parekh, A. B. (in press). Sequential forward and reverse transport of the Na+ Ca2+ exchanger generates Ca2+ oscillations within mitochondria. Nature Communications, 9, Article 156. https://doi.org/10.1038/s41467-017-02638-2

Mitochondrial Ca2+ homoeostasis regulates aerobic metabolism and cell survival. Ca2+ flux into mitochondria is mediated by the mitochondrial calcium uniporter (MCU) channel whereas Ca2+ export is often through an electrogenic Na+–Ca2+ exchanger. Here... Read More about Sequential forward and reverse transport of the Na+ Ca2+ exchanger generates Ca2+ oscillations within mitochondria.