All Outputs (10)

Hybrid Closed-Loop Therapy in Adults with Type 1 Diabetes in England: Long-Term Outcomes from a Real-World Observational Study (2025)
Journal Article
Liarakos, A. L., Crabtree, T. S., Griffin, T. P., Hussain, S., Gallen, G., Elliott, J., Furlong, N., Cranston, I., Narendran, P., Kamaruddin, S., Thabit, H., Htike, Z. Z., Leelarathna, L., Sawyer, L., Evans, M. L., Curtis, L., Philbey, C., Kirby, J., Douek, I., Chakera, A. J., …Wilmot, E. G. (2025). Hybrid Closed-Loop Therapy in Adults with Type 1 Diabetes in England: Long-Term Outcomes from a Real-World Observational Study. Diabetes Technology and Therapeutics, https://doi.org/10.1089/dia.2025.0165

Objective: To evaluate longitudinal real-world outcomes in adults with type 1 diabetes initiating hybrid closed loop (HCL).

Methods: Adults with type 1 diabetes, managed with an insulin pump and intermittently scanned continuous glucose monitorin... Read More about Hybrid Closed-Loop Therapy in Adults with Type 1 Diabetes in England: Long-Term Outcomes from a Real-World Observational Study.

Impact of real-time glucose monitoring using FreeStyle Libre 3 on glycaemia in type 2 diabetes managed with basal insulin plus SGLT2 inhibitor and/or GLP-1 agonist: the FreeDM2 randomised controlled trial protocol (2025)
Journal Article
Wilmot, E. G., Ajjan, R. A., Cheah, Y. S., Choudhary, P., Cranston, I., Elliott, R. A., Evans, M., Iqbal, A., Kamaruddin, S., Barnard-Kelly, K., Lumb, A., Min, T., Moore, P., Narendran, P., Neupane, S., Rayman, G., Sathyapalan, T., Thabit, H., Yates, T., & Leelarathna, L. (2025). Impact of real-time glucose monitoring using FreeStyle Libre 3 on glycaemia in type 2 diabetes managed with basal insulin plus SGLT2 inhibitor and/or GLP-1 agonist: the FreeDM2 randomised controlled trial protocol. BMJ Open, 15(4), Article e090154. https://doi.org/10.1136/bmjopen-2024-090154

Introduction Effective management of type 2 diabetes mellitus (T2DM) consists of lifestyle modification and therapy optimisation. While glycaemic monitoring can be used as a tool to guide these changes, this can be challenging with self-monitoring of... Read More about Impact of real-time glucose monitoring using FreeStyle Libre 3 on glycaemia in type 2 diabetes managed with basal insulin plus SGLT2 inhibitor and/or GLP-1 agonist: the FreeDM2 randomised controlled trial protocol.

Using normalisation process theory to understand implementation of effective early-onset type 2 diabetes treatment and care within England: a qualitative study (2025)
Journal Article
Chauhan, R., Davies, M. J., May, C., Misra, S., Sargeant, J. A., Skarlatos, M., Speight, J., Wilmot, E. G., Wilson, C., & Hadjiconstantinou, M. (2025). Using normalisation process theory to understand implementation of effective early-onset type 2 diabetes treatment and care within England: a qualitative study. BMC Health Services Research, 25(1), Article 422. https://doi.org/10.1186/s12913-025-12616-w

Background: Despite increasing prevalence, early-onset type 2 diabetes (EOT2D) has received little clinical and qualitative research attention within England. This qualitative study aimed to explore and understand the unmet needs of people living wit... Read More about Using normalisation process theory to understand implementation of effective early-onset type 2 diabetes treatment and care within England: a qualitative study.

Existing Knowledge Gaps in Risk Factors and Consequences of Lipohypertrophy in People Using Continuous Subcutaneous Insulin Infusion Therapy: A Systematic Review and Meta-analysis (2025)
Journal Article
Mader, J. K., Fornengo, R., Hassoun, A., Heinemann, L., Kulzer, B., Monica, M., Nguyen, T., Sieber, J., Renard, E., Reznik, Y., Ryś, P., Stożek-Tutro, A., & Wilmot, E. G. (2025). Existing Knowledge Gaps in Risk Factors and Consequences of Lipohypertrophy in People Using Continuous Subcutaneous Insulin Infusion Therapy: A Systematic Review and Meta-analysis. Journal of Diabetes Science and Technology, https://doi.org/10.1177/19322968251319806

Background:
Lipohypertrophy is a common skin complication in individuals with insulin-treated diabetes, but this condition in those using insulin pumps (continuous subcutaneous insulin infusion, CSII) remains poorly understood. This study aimed to i... Read More about Existing Knowledge Gaps in Risk Factors and Consequences of Lipohypertrophy in People Using Continuous Subcutaneous Insulin Infusion Therapy: A Systematic Review and Meta-analysis.

Risk factors for Lipohypertrophy in People With Insulin-Treated Diabetes: A Systematic Meta-Analysis (2025)
Journal Article
Mader, J. K., Fornengo, R., Hassoun, A., Heinemann, L., Kulzer, B., Monica, M., Nguyen, T., Sieber, J., Renard, E., Reznik, Y., Ryś, P., Stożek-Tutro, A., & Wilmot, E. G. (2025). Risk factors for Lipohypertrophy in People With Insulin-Treated Diabetes: A Systematic Meta-Analysis. Journal of Diabetes Science and Technology, https://doi.org/10.1177/19322968251325569

Background:
Lipohypertrophy is a common skin complication in people with insulin-treated diabetes. Despite its high prevalence and potential impact on diabetes management and outcomes, published data regarding the risk factors for the development of... Read More about Risk factors for Lipohypertrophy in People With Insulin-Treated Diabetes: A Systematic Meta-Analysis.

The challenge of assessing impaired awareness of hypoglycaemia in diabetes in the era of continuous glucose monitoring: A narrative review of evidence and translation into clinical practice (2025)
Journal Article
Berry, S. A., Liarakos, A. L., Koutroukas, V., Choudhary, P., Wilmot, E. G., & Iqbal, A. (2025). The challenge of assessing impaired awareness of hypoglycaemia in diabetes in the era of continuous glucose monitoring: A narrative review of evidence and translation into clinical practice. Diabetes, Obesity and Metabolism, 27(5), 2363-2376. https://doi.org/10.1111/dom.16284

Iatrogenic hypoglycaemia remains a major barrier in diabetes care. Over time, and with repeated hypoglycaemic episodes, the physiological responses to hypoglycaemia can become blunted, resulting in impaired awareness of hypoglycaemia (IAH). In IAH, t... Read More about The challenge of assessing impaired awareness of hypoglycaemia in diabetes in the era of continuous glucose monitoring: A narrative review of evidence and translation into clinical practice.

Implementation Strategies for Inpatient Continuous Glucose Monitoring-based Diabetes Management: A Systematic Review (2025)
Journal Article
Olsen, M. T., Liarakos, A. L., Wilmot, E. G., Dhatariya, K., Thabit, H., Sánchez-García, D., Nørgaard, K., Pedersen-Bjergaard, U., Hansen, K. B., Vangoitsenhoven, R., Mathieu, C., Kristensen, P. L., & Mader, J. K. (2025). Implementation Strategies for Inpatient Continuous Glucose Monitoring-based Diabetes Management: A Systematic Review. Journal of Clinical Endocrinology and Metabolism, 110(7), e2411–e2419. https://doi.org/10.1210/clinem/dgaf074

Introduction
Continuous glucose monitoring (CGM) provides real-time glucose data that has revolutionised outpatient diabetes care; however, its impact on inpatient care remains limited, likely due to the lack of standardised CGM-based insulin titrat... Read More about Implementation Strategies for Inpatient Continuous Glucose Monitoring-based Diabetes Management: A Systematic Review.

Existing Knowledge Gaps in Risk Factors and Consequences of Lipohypertrophy in People Using Therapy -A Systematic Review and Meta-analysis (2025)
Journal Article
Mader, J. K., Fornengo, R., Hassoun, A., Heinemann, L., Kulzer, B., Monica, M., Nguyen, T., Sieber, J., Renard, E., Reznik, Y., Ryś, P., Stożek-Tutro, A., & Wilmot, E. G. (in press). Existing Knowledge Gaps in Risk Factors and Consequences of Lipohypertrophy in People Using Therapy -A Systematic Review and Meta-analysis. Journal of Diabetes Science and Technology,

Long-Term Improvements in Glycemia and User-Reported Outcomes Associated with Open-Source Automated Insulin Delivery Systems in Adults with Type 1 Diabetes in the United Kingdom: A Real-World Observational Study (2025)
Journal Article
Liarakos, A. L., Crabtree, T. S., Hussain, S., Patel, R., Gazis, A., Mendis, B., Herring, R., Kennedy, A., Black, N., Ryder, R. E., & Wilmot, E. G. (2025). Long-Term Improvements in Glycemia and User-Reported Outcomes Associated with Open-Source Automated Insulin Delivery Systems in Adults with Type 1 Diabetes in the United Kingdom: A Real-World Observational Study. Diabetes Technology and Therapeutics, 27(4), 283-291. https://doi.org/10.1089/dia.2024.0556

Objective: To evaluate real-world outcomes in adults with type 1 diabetes initiating open-source automated insulin delivery systems (OS-AID).

Methods: Adults with type 1 diabetes who commenced OS-AID, between May 2016 and April 2021, across 12 ce... Read More about Long-Term Improvements in Glycemia and User-Reported Outcomes Associated with Open-Source Automated Insulin Delivery Systems in Adults with Type 1 Diabetes in the United Kingdom: A Real-World Observational Study.

Time Below Range and Its Influence on Hypoglycemia Awareness and Severe Hypoglycemia: Insights From the Association of British Clinical Diabetologists Study (2025)
Journal Article
Deshmukh, H., Wilmot, E. G., Choudhary, P., Ssemmondo, E., Barnes, D., Walker, N., Walton, C., Ryder, R. E., & Sathyapalan, T. (2025). Time Below Range and Its Influence on Hypoglycemia Awareness and Severe Hypoglycemia: Insights From the Association of British Clinical Diabetologists Study. Diabetes Care, 48(3), 437-443. https://doi.org/10.2337/dc24-1833

OBJECTIVE
This study aimed to explore the relationship between time below range (TBR), impaired awareness of hypoglycemia (IAH), and severe hypoglycemia (SH).

RESEARCH DESIGN AND METHODS
This cross-sectional study analyzed data from individuals... Read More about Time Below Range and Its Influence on Hypoglycemia Awareness and Severe Hypoglycemia: Insights From the Association of British Clinical Diabetologists Study.