All Outputs (36)

Effect of oral prednisolone on symptom duration and severity in nonasthmatic adults with acute lower respiratory tract infection: a randomized clinical trial (2017)
Journal Article
Hay, A. D., Little, P., Harnden, A., Thompson, M., Wang, K., Kendrick, D., …Moore, M. (2017). Effect of oral prednisolone on symptom duration and severity in nonasthmatic adults with acute lower respiratory tract infection: a randomized clinical trial. Journal of the American Medical Association, 318(8), 721-730. https://doi.org/10.1001/jama.2017.10572

© 2017 American Medical Association. All rights reserved. IMPORTANCE: Acute lower respiratory tract infection is common and often treated inappropriately in primary care with antibiotics. Corticosteroids are increasingly used but without sufficient e... Read More about Effect of oral prednisolone on symptom duration and severity in nonasthmatic adults with acute lower respiratory tract infection: a randomized clinical trial.

Venous thromboembolism in adults screened for Sickle Cell Trait: a population based cohort study with nested case-control analysis (2017)
Journal Article
Little, I., Vinogradova, Y., Orton, E., Kai, J., & Qureshi, N. (2017). Venous thromboembolism in adults screened for Sickle Cell Trait: a population based cohort study with nested case-control analysis. BMJ Open, 7(3), Article e012665. https://doi.org/10.1136/bmjopen-2016-012665

Objective: To determine whether sickle cell carriers (‘sickle cell trait’) have an increased risk of venous thromboembolism (VTE).


Design: Cohort study with nested case-control analysis.
Setting: General population with data from 609 UK gener... Read More about Venous thromboembolism in adults screened for Sickle Cell Trait: a population based cohort study with nested case-control analysis.

Association between maternal depression and anxiety episodes and rates of childhood injuries: a cohort study from England (2017)
Journal Article
Baker, R., Kendrick, D., Tata, L. J., & Orton, E. (2017). Association between maternal depression and anxiety episodes and rates of childhood injuries: a cohort study from England. Injury Prevention, 23(6), 396-402. https://doi.org/10.1136/injuryprev-2016-042294

Background: Maternal depression is common and associated with several child health outcomes. The impact on childhood injuries is underexplored, with existing studies relying on maternal reporting of injury occurrences. Using population healthcare dat... Read More about Association between maternal depression and anxiety episodes and rates of childhood injuries: a cohort study from England.

School-based education programmes for the prevention of unintentional injuries in children and young people. (2016)
Journal Article
Orton, E., Whitehead, J., Mhizha-Murira, J. R., Clarkson, M., Watson, M. C., Mulvaney, C. A., …Bhuchar, M. (2016). School-based education programmes for the prevention of unintentional injuries in children and young people. Cochrane Database of Systematic Reviews, 12(CD0102), https://doi.org/10.1002/14651858.CD010246.pub2

Background: Unintentional injuries are the leading cause of death in children aged four to 18 years and are a major cause of ill health. The school setting offers the opportunity to deliver preventive interventions to a large number of children and h... Read More about School-based education programmes for the prevention of unintentional injuries in children and young people..

Differing patterns in intentional and unintentional poisonings among young people in England, 1998-2014: a population based cohort study (2016)
Journal Article
Tyrrell, E. G., Orton, E., Sayal, K., Baker, R., & Kendrick, D. (2017). Differing patterns in intentional and unintentional poisonings among young people in England, 1998-2014: a population based cohort study. Journal of Public Health, 39(2), Article e1-e9. https://doi.org/10.1093/pubmed/fdw075

Background Accurate and up to date data on changes in poisoning incidence among young people are lacking. Recent linkage of UK primary care, hospital and mortality data allows these to be quantified to inform service delivery.

Methods An open coh... Read More about Differing patterns in intentional and unintentional poisonings among young people in England, 1998-2014: a population based cohort study.

Differing patterns in thermal injury incidence and hospitalisations among 0–4 year old children from England (2016)
Journal Article
Baker, R., Tata, L. J., Kendrick, D., Burch, T., Kennedy, M., & Orton, E. (2016). Differing patterns in thermal injury incidence and hospitalisations among 0–4 year old children from England. Burns, 42(7), 1609-1616. https://doi.org/10.1016/j.burns.2016.05.007

Objective: To describe patterns in thermal injury incidence and hospitalisations by age, sex, calendar year and socioeconomic status among 0-4 year olds in England for the period 1998-2013.

Participants: 708,050 children with linked primary care a... Read More about Differing patterns in thermal injury incidence and hospitalisations among 0–4 year old children from England.

Epidemiology of poisonings, fractures and burns among 0–24 year olds in England using linked health and mortality data (2016)
Journal Article
Baker, R., Orton, E., Tata, L. J., & Kendrick, D. (2016). Epidemiology of poisonings, fractures and burns among 0–24 year olds in England using linked health and mortality data. European Journal of Public Health, 26(6), 940-946. https://doi.org/10.1093/eurpub/ckw064

Background:
Understanding patterns of injury in England is challenging due to a lack of national injury surveillance data. Through recent linkage of a large primary care research database to hospitalization and mortality data, we describe the epide... Read More about Epidemiology of poisonings, fractures and burns among 0–24 year olds in England using linked health and mortality data.

Changes in poisonings among adolescents in the UK between 1992 and 2012: a population based cohort study (2016)
Journal Article
Tyrrell, E. G., Orton, E., & Tata, L. J. (2016). Changes in poisonings among adolescents in the UK between 1992 and 2012: a population based cohort study. Injury Prevention, 22(6), 400-406. https://doi.org/10.1136/injuryprev-2015-041901

Background: Poisonings are a common cause of morbidity and mortality among adolescents. Yet surveillance data indicating current incidence rates (IRs) and time trends are lacking, making policy development and service planning difficult. We utilised... Read More about Changes in poisonings among adolescents in the UK between 1992 and 2012: a population based cohort study.

Sex and age differences in the early identification and treatment of alcohol use: a population-based study of patients with alcoholic cirrhosis (2015)
Journal Article
Otete, H. E., Orton, E., West, J., & Fleming, K. M. (2015). Sex and age differences in the early identification and treatment of alcohol use: a population-based study of patients with alcoholic cirrhosis. Addiction, 110(12), https://doi.org/10.1111/add.13081

Aim: To estimate sex differences in health-care utilization among harmful/hazardous drinkers in the period before alcoholic cirrhosis diagnosis, and estimate sex differences in the extent to which alcohol use and brief alcohol interventions were docu... Read More about Sex and age differences in the early identification and treatment of alcohol use: a population-based study of patients with alcoholic cirrhosis.

Identification of incident poisoning, fracture and burn events using linked primary care, secondary care, and mortality data from England: implications for research and surveillance (2015)
Journal Article
Baker, R., Tata, L. J., Kendrick, D., & Orton, E. (2015). Identification of incident poisoning, fracture and burn events using linked primary care, secondary care, and mortality data from England: implications for research and surveillance. Injury Prevention, https://doi.org/10.1136/injuryprev-2015-041561

Background: English national injury data collection systems are restricted to hospitalisations and deaths. With recent linkage of a large primary care database, the Clinical Practice Research Datalink (CPRD), with secondary care and mortality data we... Read More about Identification of incident poisoning, fracture and burn events using linked primary care, secondary care, and mortality data from England: implications for research and surveillance.

Risk factors for long-bone fractures in children up to 5 years of age: a nested case–control study (2015)
Journal Article
Baker, R., Orton, E., Tata, L. J., & Kendrick, D. (2015). Risk factors for long-bone fractures in children up to 5 years of age: a nested case–control study. Archives of Disease in Childhood, 100(5), https://doi.org/10.1136/archdischild-2013-305715

Aim: To investigate risk factors for first long-bone fractures in children up to 5 years old in order to provide evidence about which families could benefit from injury prevention interventions.
Methods: Population-based matched nested case–control... Read More about Risk factors for long-bone fractures in children up to 5 years of age: a nested case–control study.

Can oral corticosteroids reduce the severity or duration of an acute cough, and the associated National Health Service and societal costs, in adults presenting to primary care?: study protocol for a randomised controlled trial (2015)
Journal Article
Downing, H. E., Carroll, F., Brookes, S. T., Hollinghurst, S., Timmins, D., Orton, E., …Hay, A. D. (2015). Can oral corticosteroids reduce the severity or duration of an acute cough, and the associated National Health Service and societal costs, in adults presenting to primary care?: study protocol for a randomised controlled trial. Trials, 16(1), Article 78. https://doi.org/10.1186/s13063-015-0569-5

Background:
Acute lower respiratory tract infection (LRTI) is one of the most common conditions managed internationally and is costly to health services and patients. Despite good evidence that antibiotics are not effective for improving the symptom... Read More about Can oral corticosteroids reduce the severity or duration of an acute cough, and the associated National Health Service and societal costs, in adults presenting to primary care?: study protocol for a randomised controlled trial.

Persistence of health inequalities in childhood injury in the UK: a population-based cohort study of children under 5 (2014)
Journal Article
Orton, E., Kendrick, D., West, J., & Tata, L. J. (2014). Persistence of health inequalities in childhood injury in the UK: a population-based cohort study of children under 5. PLoS ONE, 9(10), Article e111631. https://doi.org/10.1371/journal.pone.0111631

BACKGROUND: Injury is a significant cause of childhood death and can result in substantial long-term disability. Injuries are more common in children from socio-economically deprived families, contributing to health inequalities between the most and... Read More about Persistence of health inequalities in childhood injury in the UK: a population-based cohort study of children under 5.

Risk factors for scald injury in children under 5 years of age: a case–control study using routinely collected data (2013)
Journal Article
Shah, M., Orton, E., Tata, L., Gomes, C., & Kendrick, D. (2013). Risk factors for scald injury in children under 5 years of age: a case–control study using routinely collected data. Burns, 39(7), https://doi.org/10.1016/j.burns.2013.03.022

Scald injury is common, accounting for half of all burns in pre-school children. Most scalds are preventable and health professionals can play an important role in targeting interventions to those at greatest risk. However, the potential for routinel... Read More about Risk factors for scald injury in children under 5 years of age: a case–control study using routinely collected data.

Equity of uptake of a diabetic retinopathy screening programme in a geographically and socio-economically diverse population (2013)
Journal Article
Orton, E., Forbes-Haley, A., Tunbridge, L., & Cohenc, S. (2013). Equity of uptake of a diabetic retinopathy screening programme in a geographically and socio-economically diverse population. Public Health, 127(9), https://doi.org/10.1016/j.puhe.2013.04.015

Objectives
At the time of undertaking the audit, the uptake of diabetic retinopathy screening in Derbyshire was 73%, below the national standard of 80%. To assess equity of access to diabetic retinopathy screening in a geographically and ethnically... Read More about Equity of uptake of a diabetic retinopathy screening programme in a geographically and socio-economically diverse population.

Independent risk factors for injury in pre-school children: three population-based nested case-control studies using routine primary care data (2012)
Journal Article
Orton, E., Kendrick, D., West, J., & Tata, L. J. (2012). Independent risk factors for injury in pre-school children: three population-based nested case-control studies using routine primary care data. PLoS ONE, 7(4), Article e35193. https://doi.org/10.1371/journal.pone.0035193

Background: Injuries in childhood are largely preventable yet an estimated 2,400 children die every day because of injury and violence. Despite this, the factors that contribute to injury occurrence have not been quantified at the population scale us... Read More about Independent risk factors for injury in pre-school children: three population-based nested case-control studies using routine primary care data.