All Outputs (25)

Defining the disturbance in cortical glutamate and GABA function in psychosis and its origins and consequences (2024)
Working Paper

It is widely thought that the onset of psychotic symptoms in schizophrenia may arise from an early neurotoxic phase, possibly related to oxidative stress or inflammation, and a late residual damage phase associated with persistent negative symptoms.... Read More about Defining the disturbance in cortical glutamate and GABA function in psychosis and its origins and consequences.

We need timely access to mental health data: implications of the Goldacre review (2023)
Journal Article

The Goldacre review, published in April, 2022, 1 is a landmark evaluation of the use, availability, and safety of National Health Service (NHS) data across all four nations of the UK. The review underscores the necessary role of data in driving healt... Read More about We need timely access to mental health data: implications of the Goldacre review.

Beta-frequency electrophysiological bursts: BOLD correlates and relationships with psychotic illness (2021)
Journal Article

Regional Brain Correlates of Beta Bursts in Health and Psychosis: A Concurrent Electroencephalography and Functional Magnetic Resonance Imaging Study (2020)
Journal Article

Background: There is emerging evidence for abnormal beta oscillations in psychosis. Beta oscillations are likely to play a key role in the coordination of sensorimotor information that is crucial to healthy mental function. Growing evidence suggests... Read More about Regional Brain Correlates of Beta Bursts in Health and Psychosis: A Concurrent Electroencephalography and Functional Magnetic Resonance Imaging Study.

Lateralization of attention in adults with ADHD: Evidence of pseudoneglect (2020)
Journal Article

Background. We investigated whether adults with attention-deficit/hyperactivity disorder (ADHD) show pseudoneglect—preferential allocation of attention to the left visual field (LVF) and a resulting slowing of mean reaction times (MRTs) in the right... Read More about Lateralization of attention in adults with ADHD: Evidence of pseudoneglect.

Quantifying the core deficit in classical schizophrenia (2020)
Journal Article

In the classical descriptions of schizophrenia, Kraepelin and Bleuler recognised disorganization and impoverishment of mental activity as fundamental symptoms. Their classical descriptions also included a tendency to persisting disability. The psycho... Read More about Quantifying the core deficit in classical schizophrenia.

Neurological and psychiatric adverse effects of long-term methylphenidate treatment in ADHD: A map of the current evidence (2019)
Journal Article

Methylphenidate (MPH), the most common medication for children with Attention Deficit/Hyperactivity Disorder (ADHD) in many countries, is often prescribed for long periods of time. Any long-term psychotropic treatment in childhood raises concerns abo... Read More about Neurological and psychiatric adverse effects of long-term methylphenidate treatment in ADHD: A map of the current evidence.

Reduced Prefrontal Gyrification in Carriers of the Dopamine D4 Receptor 7-Repeat Allele With Attention Deficit/Hyperactivity Disorder: A Preliminary Report (2019)
Journal Article

Objective: Structural and functional abnormalities have been noted in the prefrontal cortex of individuals with neurodevelopmental disorders such as attention deficit/hyperactivity disorder (ADHD). Cortical thickness and gyrification, both of which h... Read More about Reduced Prefrontal Gyrification in Carriers of the Dopamine D4 Receptor 7-Repeat Allele With Attention Deficit/Hyperactivity Disorder: A Preliminary Report.

Development of human electrophysiological brain networks (2018)
Journal Article

Functional activity in the human brain is intrinsically organized into independently active, connected brain regions. These networks include sensorimotor systems, as well as higher-order cognitive networks such as the default mode network (DMN), whic... Read More about Development of human electrophysiological brain networks.

Effects of long-term methylphenidate use on growth and blood pressure: results of the German Health Interview and Examination Survey for Children and Adolescents (KiGGS) (2018)
Journal Article

© 2018 The Author(s). Background: Concerns have been raised over the safety of methylphenidate (MPH), with regard to adverse effects on growth and blood pressure. Our study investigates whether, and to what extent, methylphenidate use in boys with AD... Read More about Effects of long-term methylphenidate use on growth and blood pressure: results of the German Health Interview and Examination Survey for Children and Adolescents (KiGGS).

Attenuated post-movement beta rebound associated with schizotypal features in healthy people (2018)
Journal Article

© The Author(s) 2018. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. Introduction: Schizophrenia and schizotypal personality disorder (SPD) lie on a single spectrum of mental illness and converging evidenc... Read More about Attenuated post-movement beta rebound associated with schizotypal features in healthy people.

Changes in electrophysiological markers of cognitive control after administration of galantamine (2018)
Journal Article

© 2018 The healthy brain is able to maintain a stable balance between bottom-up sensory processing and top-down cognitive control. The neurotransmitter acetylcholine plays a substantial role in this. Disruption of this balance could contribute to sym... Read More about Changes in electrophysiological markers of cognitive control after administration of galantamine.

Glutathione and glutamate in schizophrenia: a 7T MRS study (2018)
Journal Article

© 2018 The Author(s) In schizophrenia, abnormal neural metabolite concentrations may arise from cortical damage following neuroinflammatory processes implicated in acute episodes. Inflammation is associated with increased glutamate, whereas the antio... Read More about Glutathione and glutamate in schizophrenia: a 7T MRS study.

Altered temporal stability in dynamic neural networks underlies connectivity changes in neurodevelopment (2018)
Journal Article

Network connectivity is an integral feature of human brain function, and characterising its maturational trajectory is a critical step towards understanding healthy and atypical neurodevelopment. Here, we used magnetoencephalography (MEG) to investig... Read More about Altered temporal stability in dynamic neural networks underlies connectivity changes in neurodevelopment.

Association of Risk of Suicide Attempts With Methylphenidate Treatment (2017)
Journal Article

IMPORTANCE Patients with attention-deficit/hyperactivity disorder (ADHD) are at an increased risk of attempting suicide. Stimulants, such as methylphenidate hydrochloride, are the most common treatment for ADHD, but the association between their ther... Read More about Association of Risk of Suicide Attempts With Methylphenidate Treatment.

Methylphenidate and the risk of psychotic disorders and hallucinations in children and adolescents in a large health system (2016)
Journal Article

Previous studies have suggested that risk of psychotic events may be increased in children exposed to methylphenidate (MPH). However, this risk has not been fully examined and the possibility of confounding factors has not been excluded. Patients age... Read More about Methylphenidate and the risk of psychotic disorders and hallucinations in children and adolescents in a large health system.

A multi-layer network approach to MEG connectivity analysis (2016)
Journal Article

© 2016 The Authors. Recent years have shown the critical importance of inter-regional neural network connectivity in supporting healthy brain function. Such connectivity is measurable using neuroimaging techniques such as MEG, however the richness of... Read More about A multi-layer network approach to MEG connectivity analysis.

Abnormal salience signaling in schizophrenia: The role of integrative beta oscillations: Salience Signaling in Schizophrenia (2016)
Journal Article

Aberrant salience attribution and cerebral dysconnectivity both have strong evidential support as core dysfunctions in schizophrenia. Aberrant salience arising from an excess of dopamine activity has been implicated in delusions and hallucinations, e... Read More about Abnormal salience signaling in schizophrenia: The role of integrative beta oscillations: Salience Signaling in Schizophrenia.

Morphological abnormalities in prefrontal surface area and thalamic volume in attention deficit/hyperactivity disorder (2015)
Journal Article

Although previous morphological studies have demonstrated abnormalities in prefrontal cortical thickness in children with attention deficit/hyperactivity disorder (ADHD), studies investigating cortical surface area are lacking. As the development of... Read More about Morphological abnormalities in prefrontal surface area and thalamic volume in attention deficit/hyperactivity disorder.

Functional connectivity in MRI is driven by spontaneous BOLD events (2015)
Journal Article