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Defining the disturbance in cortical glutamate and GABA function in psychosis and its origins and consequences (2024)
Working Paper

It is widely thought that the onset of psychotic symptoms in schizophrenia may arise from an early neurotoxic phase, possibly related to oxidative stress or inflammation, and a late residual damage phase associated with persistent negative symptoms.... Read More about Defining the disturbance in cortical glutamate and GABA function in psychosis and its origins and consequences.

Regional Brain Correlates of Beta Bursts in Health and Psychosis: A Concurrent Electroencephalography and Functional Magnetic Resonance Imaging Study (2020)
Journal Article

Background: There is emerging evidence for abnormal beta oscillations in psychosis. Beta oscillations are likely to play a key role in the coordination of sensorimotor information that is crucial to healthy mental function. Growing evidence suggests... Read More about Regional Brain Correlates of Beta Bursts in Health and Psychosis: A Concurrent Electroencephalography and Functional Magnetic Resonance Imaging Study.

Development of human electrophysiological brain networks (2018)
Journal Article
Briley, P. M., Liddle, E. B., Groom, M. J., Smith, H. J. F., Morris, P. G., Colclough, G. L., …Liddle, P. F. (2018). Development of human electrophysiological brain networks. Journal of Neurophysiology, 120(6), 3122-3130. https://doi.org/10.1152/jn.00293.2018

Functional activity in the human brain is intrinsically organized into independently active, connected brain regions. These networks include sensorimotor systems, as well as higher-order cognitive networks such as the default mode network (DMN), whic... Read More about Development of human electrophysiological brain networks.

Effects of long-term methylphenidate use on growth and blood pressure: results of the German Health Interview and Examination Survey for Children and Adolescents (KiGGS) (2018)
Journal Article
McCarthy, S., Neubert, A., Man, K. K. C., Banaschewski, T., Buitelaar, J., Carucci, S., …Wong, I. C. K. (2018). Effects of long-term methylphenidate use on growth and blood pressure: results of the German Health Interview and Examination Survey for Children and Adolescents (KiGGS). BMC Psychiatry, 18(1), Article 327. https://doi.org/10.1186/s12888-018-1884-7

© 2018 The Author(s). Background: Concerns have been raised over the safety of methylphenidate (MPH), with regard to adverse effects on growth and blood pressure. Our study investigates whether, and to what extent, methylphenidate use in boys with AD... Read More about Effects of long-term methylphenidate use on growth and blood pressure: results of the German Health Interview and Examination Survey for Children and Adolescents (KiGGS).

Changes in electrophysiological markers of cognitive control after administration of galantamine (2018)
Journal Article
Robson, S. E., Gascoyne, L. E., Mullinger, K. J., Robson, S., Kumar, J., O'Neill, G. C., …Liddle, P. F. (2018). Changes in electrophysiological markers of cognitive control after administration of galantamine. NeuroImage: Clinical, 20, 228-235. https://doi.org/10.1016/j.nicl.2018.07.019

© 2018 The healthy brain is able to maintain a stable balance between bottom-up sensory processing and top-down cognitive control. The neurotransmitter acetylcholine plays a substantial role in this. Disruption of this balance could contribute to sym... Read More about Changes in electrophysiological markers of cognitive control after administration of galantamine.

Association of Risk of Suicide Attempts With Methylphenidate Treatment (2017)
Journal Article
Man, K. K., Coghill, D., Chan, E. W., Lau, W. C., Hollis, C., Liddle, E., …Wong, I. C. (2017). Association of Risk of Suicide Attempts With Methylphenidate Treatment. JAMA Psychiatry, 74(10), 1048-1055. https://doi.org/10.1001/jamapsychiatry.2017.2183

IMPORTANCE Patients with attention-deficit/hyperactivity disorder (ADHD) are at an increased risk of attempting suicide. Stimulants, such as methylphenidate hydrochloride, are the most common treatment for ADHD, but the association between their ther... Read More about Association of Risk of Suicide Attempts With Methylphenidate Treatment.

Methylphenidate and the risk of psychotic disorders and hallucinations in children and adolescents in a large health system (2016)
Journal Article
Man, K. K., Coghill, D., Chan, E. W., Lau, W. C., Hollis, C., Liddle, E., …Wong, I. C. (in press). Methylphenidate and the risk of psychotic disorders and hallucinations in children and adolescents in a large health system. Translational Psychiatry, 6, Article e956. https://doi.org/10.1038/tp.2016.216

Previous studies have suggested that risk of psychotic events may be increased in children exposed to methylphenidate (MPH). However, this risk has not been fully examined and the possibility of confounding factors has not been excluded. Patients age... Read More about Methylphenidate and the risk of psychotic disorders and hallucinations in children and adolescents in a large health system.

Abnormal salience signaling in schizophrenia: The role of integrative beta oscillations: Salience Signaling in Schizophrenia (2016)
Journal Article
Liddle, E. B., Price, D., Palaniyappan, L., Brookes, M. J., Robson, S. E., Hall, E. L., …Liddle, P. F. (2016). Abnormal salience signaling in schizophrenia: The role of integrative beta oscillations: Salience Signaling in Schizophrenia. Human Brain Mapping, 37(4), 1361-1374. https://doi.org/10.1002/hbm.23107

Aberrant salience attribution and cerebral dysconnectivity both have strong evidential support as core dysfunctions in schizophrenia. Aberrant salience arising from an excess of dopamine activity has been implicated in delusions and hallucinations, e... Read More about Abnormal salience signaling in schizophrenia: The role of integrative beta oscillations: Salience Signaling in Schizophrenia.

Morphological abnormalities in prefrontal surface area and thalamic volume in attention deficit/hyperactivity disorder (2015)
Journal Article

Although previous morphological studies have demonstrated abnormalities in prefrontal cortical thickness in children with attention deficit/hyperactivity disorder (ADHD), studies investigating cortical surface area are lacking. As the development of... Read More about Morphological abnormalities in prefrontal surface area and thalamic volume in attention deficit/hyperactivity disorder.

Dissociated large-scale functional connectivity networks of the precuneus in medication-naïve first-episode depression (2015)
Journal Article

An imbalance in neural activity within large-scale networks appears to be an important pathophysiological aspect of depression. Yet, there is little consensus regarding the abnormality within the default mode network (DMN) in major depressive disorde... Read More about Dissociated large-scale functional connectivity networks of the precuneus in medication-naïve first-episode depression.

Motivational incentives and methylphenidate enhance electrophysiological correlates of error monitoring in children with attention deficit/hyperactivity disorder (2013)
Journal Article
Groom, M. J., Liddle, E. B., Scerif, G., Liddle, P. F., Batty, M. J., Liotti, M., & Hollis, C. (2013). Motivational incentives and methylphenidate enhance electrophysiological correlates of error monitoring in children with attention deficit/hyperactivity disorder. Journal of Child Psychology and Psychiatry, 54(8), https://doi.org/10.1111/jcpp.12069

Background Children with attention deficit hyperactivity disorder (ADHD) are characterised by developmentally inappropriate levels of hyperactivity, impulsivity and/or inattention and are particularly impaired when performing tasks that require a hi... Read More about Motivational incentives and methylphenidate enhance electrophysiological correlates of error monitoring in children with attention deficit/hyperactivity disorder.

Motion-related artefacts in EEG predict neuronally plausible patterns of activation in fMRI data (2012)
Journal Article
Jansen, M., White, T. P., Mullinger, K. J., Liddle, E. B., Gowland, P. A., Francis, S. T., …Liddle, P. F. (2012). Motion-related artefacts in EEG predict neuronally plausible patterns of activation in fMRI data. NeuroImage, 59(1), https://doi.org/10.1016/j.neuroimage.2011.06.094

The simultaneous acquisition and subsequent analysis of EEG and fMRI data is challenging owing to increased noise levels in the EEG data. A common method to integrate data from these two modalities is to use aspects of the EEG data, such as the ampli... Read More about Motion-related artefacts in EEG predict neuronally plausible patterns of activation in fMRI data.

Task-related default mode network modulation and inhibitory control in ADHD: effects of motivation and methylphenidate (2011)
Journal Article
Liddle, E. B., Hollis, C., Batty, M. J., Groom, M. J., Totman, J. J., Liotti, M., …Liddle, P. F. (2011). Task-related default mode network modulation and inhibitory control in ADHD: effects of motivation and methylphenidate. Journal of Child Psychology and Psychiatry, 52(7), https://doi.org/10.1111/j.1469-7610.2010.02333.x

Background: Deficits characteristic of Attention Deficit/Hyperactivity Disorder (ADHD), including poor attention and inhibitory control, are at least partially alleviated by factors that increase engagement of attention, suggesting a hypodopaminergic... Read More about Task-related default mode network modulation and inhibitory control in ADHD: effects of motivation and methylphenidate.