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All Outputs (134)

Winter cancellations of elective surgical procedures in the UK: a questionnaire survey of patients on the economic and psychological impact (2019)
Journal Article
Herrod, P. J. J., Adiamah, A., Boyd-Carson, H., Daliya, P., El-Sharkawy, A. M., Sarmah, P. B., …Lobo, D. N. (2019). Winter cancellations of elective surgical procedures in the UK: a questionnaire survey of patients on the economic and psychological impact. BMJ Open, 9(9), 1-8. https://doi.org/10.1136/bmjopen-2018-028753

Objectives To quantify the economic and psychological impact of the cancellation of operations due to winter pressures on patients, their families and the economy. Design This questionnaire study was designed with the help of patient groups. Data... Read More about Winter cancellations of elective surgical procedures in the UK: a questionnaire survey of patients on the economic and psychological impact.

Perioperative Probiotics or Synbiotics in Adults Undergoing Elective Abdominal Surgery: A Systematic Review and Meta-analysis of Randomized Controlled Trials (2019)
Journal Article
Chowdhury, A., Adiamah, A., Kushairi, A., Varadhan, K. K., Krznaric, Z., Kulkarni, A. D., …Lobo, D. N. (2020). Perioperative Probiotics or Synbiotics in Adults Undergoing Elective Abdominal Surgery: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Annals of Surgery, 271(6), 1036-1047. https://doi.org/10.1097/sla.0000000000003581

This meta-analysis of 34 randomized controlled trials reporting on 2723 participants has shown that perioperative administration of either probiotics or synbiotics was well tolerated and significantly reduced the risk of infectious complications foll... Read More about Perioperative Probiotics or Synbiotics in Adults Undergoing Elective Abdominal Surgery: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Thioredoxin system protein expression in carcinomas of the pancreas, bile duct and ampulla (2019)
Preprint / Working Paper
Al-hadyan, K., Storr, S., Zaitoun, A., Lobo, D., & Martin, S. Thioredoxin system protein expression in carcinomas of the pancreas, bile duct and ampulla

Background: Pancreatic cancer (PC), including the ampulla and bile duct, is very aggressive, and thus difficult to treat with effective therapies. The current treatment options have failed to improve PC five-year survival rates over the last 30 to 40... Read More about Thioredoxin system protein expression in carcinomas of the pancreas, bile duct and ampulla.

A systematic review of patient reported outcome measures (PROMs) and quality of life reporting in patients undergoing laparoscopic cholecystectomy (2019)
Journal Article
Daliya, P., Gemmill, E. H., Lobo, D. N., & Parsons, S. L. (2019). A systematic review of patient reported outcome measures (PROMs) and quality of life reporting in patients undergoing laparoscopic cholecystectomy. Hepatobiliary Surgery and Nutrition, 8(3), 228-245. https://doi.org/10.21037/hbsn.2019.03.16

Background Patient Reported Outcome Measures (PROMs) provide a valuable means of measuring outcomes subjectively from a patient's perspective, facilitating the assessment of service quality across healthcare providers, and assisting patients and clin... Read More about A systematic review of patient reported outcome measures (PROMs) and quality of life reporting in patients undergoing laparoscopic cholecystectomy.

Opioid stewardship: a need for opioid discharge guidance: comment on Br J Anaesth 2018 Dec 28 (2019)
Journal Article
Levy, N., Lobo, D. N., Fawcett, W. J., Ljungqvist, O., & Scott, M. J. (2019). Opioid stewardship: a need for opioid discharge guidance: comment on Br J Anaesth 2018 Dec 28. British Journal of Anaesthesia, 22(6), e215–e216. https://doi.org/10.1016/j.bja.2019.01.028

We read with interest the special and insightful article by Soffin and colleagues1 on the prescription opioid crisis. They carefully examine many of the drivers for subsequent opioid dependence after surgery and provide suggestions on how practice ca... Read More about Opioid stewardship: a need for opioid discharge guidance: comment on Br J Anaesth 2018 Dec 28.

The Impact of Preoperative Immune Modulating Nutrition on Outcomes in Patients Undergoing Surgery for Gastrointestinal Cancer: A Systematic Review and Meta-analysis (2019)
Journal Article
Adiamah, A., Skořepa, P., Weimann, A., & Lobo, D. N. (2019). The Impact of Preoperative Immune Modulating Nutrition on Outcomes in Patients Undergoing Surgery for Gastrointestinal Cancer: A Systematic Review and Meta-analysis. Annals of Surgery, 270(2), 247-246. https://doi.org/10.1097/SLA.0000000000003256

Objective: To define the influence of preoperative immune modulating nutrition (IMN) on postoperative outcomes in patients undergoing surgery for gastrointestinal cancer. Summary background data: Although studies have shown that perioperative IMN... Read More about The Impact of Preoperative Immune Modulating Nutrition on Outcomes in Patients Undergoing Surgery for Gastrointestinal Cancer: A Systematic Review and Meta-analysis.

The death of Charlotte Brontë from hyperemesis gravidarum and refeeding syndrome: A new perspective (2019)
Journal Article
Allison, S. P., & Lobo, D. N. (2020). The death of Charlotte Brontë from hyperemesis gravidarum and refeeding syndrome: A new perspective. Clinical Nutrition, 39(1), 304-305. https://doi.org/10.1016/j.clnu.2019.01.027

Many theories have been advanced concerning the cause of Charlotte Bronte’s death, none of which fully explain all the symptoms she experienced in the course of her final illness. Her death certificate records the cause of death as phthisis (tubercul... Read More about The death of Charlotte Brontë from hyperemesis gravidarum and refeeding syndrome: A new perspective.

The effects of terlipressin and direct portacaval shunting on liver hemodynamics following 80% hepatectomy in the pig (2019)
Journal Article
Hammond, J. S., Godtliebsen, F., Steigen, S., Guha, I. N., Wyatt, J., Revhaug, A., …Mortensen, K. E. (2019). The effects of terlipressin and direct portacaval shunting on liver hemodynamics following 80% hepatectomy in the pig. Clinical Science, 133(1), 153-166. https://doi.org/10.1042/CS20180858

Liver failure is the major cause of death following liver resection. Post-resection portal venous pressure (PVP) predicts liver failure, is implicated in its pathogenesis and when PVP is reduced, rates of liver dysfunction decrease. The aim of this s... Read More about The effects of terlipressin and direct portacaval shunting on liver hemodynamics following 80% hepatectomy in the pig.

Guidelines for Perioperative Care in Elective Colorectal Surgery: Enhanced Recovery After Surgery (ERAS®) Society Recommendations: 2018 (2018)
Journal Article
Gustafsson, U. O., Scott, M. J., Hubner, M., Nygren, J., Demartines, N., Francis, N., …Ljungqvist, O. (2019). Guidelines for Perioperative Care in Elective Colorectal Surgery: Enhanced Recovery After Surgery (ERAS®) Society Recommendations: 2018. World Journal of Surgery, 43(3), 659-695. https://doi.org/10.1007/s00268-018-4844-y

Background: This is the fourth updated Enhanced Recovery After Surgery (ERAS®) Society guideline presenting a consensus for optimal perioperative care in colorectal surgery and providing graded recommendations for each ERAS item within the ERAS® prot... Read More about Guidelines for Perioperative Care in Elective Colorectal Surgery: Enhanced Recovery After Surgery (ERAS®) Society Recommendations: 2018.

The reporting on ERAS Compliance, Outcomes, and Elements Research (RECOvER) checklist: a joint statement by the ERAS® and ERAS® USA societies (2018)
Journal Article
Elias, K. M., Stone, A. B., McGinigle, K., Tankou, J. I., Scott, M. J., Fawcett, W. J., …the ERAS® Society and ERAS® USA. (2019). The reporting on ERAS Compliance, Outcomes, and Elements Research (RECOvER) checklist: a joint statement by the ERAS® and ERAS® USA societies. World Journal of Surgery, 43(1), 1-8. https://doi.org/10.1007/s00268-018-4753-0

Background: Enhanced Recovery After Surgery (ERAS) programs are multimodal care pathways designed to minimize the physiologic and psychological impact of surgery for patients. Increased compliance with ERAS guidelines is associated with improved pati... Read More about The reporting on ERAS Compliance, Outcomes, and Elements Research (RECOvER) checklist: a joint statement by the ERAS® and ERAS® USA societies.

PET-PANC: multicentre prospective diagnostic accuracy and health economic analysis study of the impact of combined modality 18fluorine-2-fluoro-2-deoxy-d-glucose positron emission tomography with computed tomography scanning in the diagnosis and management of pancreatic cancer (2018)
Journal Article
Ghaneh, P., Hanson, R., Titman, A., Lancaster, G., Plumpton, C., Lloyd-Williams, H., …Neoptolemos, J. P. (2018). PET-PANC: multicentre prospective diagnostic accuracy and health economic analysis study of the impact of combined modality 18fluorine-2-fluoro-2-deoxy-d-glucose positron emission tomography with computed tomography scanning in the diagnosis and management of pancreatic cancer. Health Technology Assessment, 22(7), 1-114. https://doi.org/10.3310/hta22070

Background: Pancreatic cancer diagnosis and staging can be difficult in 10–20% of patients. Positron emission tomography (PET)/computed tomography (CT) adds precise anatomical localisation to functional data. The use of PET/CT may add further value t... Read More about PET-PANC: multicentre prospective diagnostic accuracy and health economic analysis study of the impact of combined modality 18fluorine-2-fluoro-2-deoxy-d-glucose positron emission tomography with computed tomography scanning in the diagnosis and management of pancreatic cancer.

Consensus on Training and Implementation of Enhanced Recovery After Surgery: A Delphi Study (2018)
Journal Article
Francis, N. K., Walker, T., Carter, F., Hübner, M., Balfour, A., Jakobsen, D. H., …Ljungqvist, O. (2018). Consensus on Training and Implementation of Enhanced Recovery After Surgery: A Delphi Study. World Journal of Surgery, 42(7), 1919–1928. https://doi.org/10.1007/s00268-017-4436-2

Background Enhanced Recovery After Surgery (ERAS) is widely accepted in current surgical practice due to its positive impact on patient outcomes. The successful implementation of ERAS is chal-lenging and compliance with protocols varies widely. Cont... Read More about Consensus on Training and Implementation of Enhanced Recovery After Surgery: A Delphi Study.

Development of a telehealth monitoring service after colorectal surgery: a feasibility study (2017)
Journal Article
Bragg, D. D., Edis, H., Clark, S., Parsons, S. L., Perumpalath, B., Lobo, D. N., & Maxwell-Armstrong, C. A. (in press). Development of a telehealth monitoring service after colorectal surgery: a feasibility study. World Journal of Gastroenterology, 9(9), https://doi.org/10.4240/wjgs.v9.i9.193

AIM: To evaluate the feasibility of a text-messaging system to remotely monitor and support patients after discharge following elective colorectal surgery, within an enhanced recovery protocol. METHODS: Florence (FLO) is a National Health Service te... Read More about Development of a telehealth monitoring service after colorectal surgery: a feasibility study.

Pancreas preserving distal duodenectomy: a versatile operation for a range of infra-papillary pathologies (2017)
Journal Article
Mitchell, W. K., Thomas, P. F., Zaitoun, A. M., Brooks, A. J., & Lobo, D. N. (in press). Pancreas preserving distal duodenectomy: a versatile operation for a range of infra-papillary pathologies. World Journal of Gastroenterology, 23(23), https://doi.org/10.3748/wjg.v23.i23.4252

AIM To investigate the range of pathologies treated by pancreas preserving distal duodenectomy (PPDD) and present the outcome of follow-up. METHODS Neoplastic lesions of the duodenum are treated conventionally by pancreaticoduodenectomy. Les... Read More about Pancreas preserving distal duodenectomy: a versatile operation for a range of infra-papillary pathologies.

Spontaneous central venous thrombosis and shunt occlusion following peritoneovenous shunt placement for intractable ascites (2017)
Journal Article
Hariharan, D., Wilkes, E. A., Aithal, G. P., Travis, S., & Lobo, D. N. (2017). Spontaneous central venous thrombosis and shunt occlusion following peritoneovenous shunt placement for intractable ascites. Annals of The Royal College of Surgeons of England, 99(5), Article e145-e147. https://doi.org/10.1308/rcsann.2017.0058

A 43-year-old man had a peritoneovenous shunt inserted for the treatment of chylous ascites secondary to myelofibrosis. Despite being on anticoagulation for superior mesenteric vein thrombosis, he developed shunt dysfunction within two weeks of inser... Read More about Spontaneous central venous thrombosis and shunt occlusion following peritoneovenous shunt placement for intractable ascites.

Spontaneous extrusion of gallstones after percutaneous drainage (2017)
Journal Article
Hariharan, D., & Lobo, D. N. (2017). Spontaneous extrusion of gallstones after percutaneous drainage. Annals of The Royal College of Surgeons of England, 99(3), Article e1-e2. https://doi.org/10.1308/rcsann.2017.0015

There have been reports of late discharge of gallstones through operative wounds after spillage into the peritoneal cavity during laparoscopic cholecystectomy and after the development of spontaneous cholecystocutaneous fistulae. However, spontaneous... Read More about Spontaneous extrusion of gallstones after percutaneous drainage.

Immune dysfunction in patients with obstructive jaundice before and after endoscopic retrograde cholangiopancreatography (2016)
Journal Article
Chowdhury, A. H., Camara, M., Martinez-Pomares, L., Zaitoun, A. M., Eremin, O., Aithal, G. P., & Lobo, D. (2016). Immune dysfunction in patients with obstructive jaundice before and after endoscopic retrograde cholangiopancreatography. Clinical Science, 130(17), 1535-1544. https://doi.org/10.1042/CS20160326

© 2016 The Author(s). This prospective observational study investigated monocyte cytokine responses to lipopolysaccharide (LPS) in patients with obstructive jaundice (OJ) before and after endoscopic biliary drainage. Dendritic cell (DC) subsets and t... Read More about Immune dysfunction in patients with obstructive jaundice before and after endoscopic retrograde cholangiopancreatography.

A dangerous loop (2016)
Journal Article
Ahmad, S., Bragg, D., Zaitoun, A., & Lobo, D. N. (in press). A dangerous loop. Clinical Case Reports, 4(5), https://doi.org/10.1002/ccr3.563

Key Clinical Message: A 76-year-old man developed a hemoperitoneum after ERCP for choledocholithiasis. He underwent a laparotomy and splenectomy for a capsular tear at the splenic hilum, a rare complication of ERCP. “Bowing” of the endoscope with to... Read More about A dangerous loop.

Intraoperative Goal-directed Fluid Therapy in Elective Major Abdominal Surgery: A Meta-analysis of Randomized Controlled Trials (2016)
Journal Article
Rollins, K. E., & Lobo, D. N. (2016). Intraoperative Goal-directed Fluid Therapy in Elective Major Abdominal Surgery: A Meta-analysis of Randomized Controlled Trials. Annals of Surgery, 263(3), 465-476. https://doi.org/10.1097/sla.0000000000001366

Objectives: To compare the effects of intraoperative goal-directed fluid therapy (GDFT) with conventional fluid therapy, and determine whether there was a difference in outcome between studies that did and did not use Enhanced Recovery After Surg... Read More about Intraoperative Goal-directed Fluid Therapy in Elective Major Abdominal Surgery: A Meta-analysis of Randomized Controlled Trials.