Skip to main content

Research Repository

Advanced Search

All Outputs (68)

Trajectories of pain predict disabilities affecting daily living in arthritis (2019)
Journal Article
James, R. J., Walsh, D. A., & Ferguson, E. (2019). Trajectories of pain predict disabilities affecting daily living in arthritis. British Journal of Health Psychology, 24(3), 465-496. https://doi.org/10.1111/bjhp.12364

Purpose: To examine the interplay between pain and disability in arthritis when adjusting for patient heterogeneity in pain progression. There is consistent evidence to suggest that people experience osteoarthritis heterogeneously, with subgroups of... Read More about Trajectories of pain predict disabilities affecting daily living in arthritis.

Associations of symptomatic knee OA with histopathologic features in subchondral bone (2019)
Journal Article
McWilliams, D. F., shahtaheri, S., Walsh, D. A., Aso, K., Wilson, D., & Hill, R. (2019). Associations of symptomatic knee OA with histopathologic features in subchondral bone. Arthritis and Rheumatology, 71(6), 916-924. https://doi.org/10.1002/art.40820

© 2019, American College of Rheumatology Objective: Subchondral bone and the osteochondral junction are thought to contribute to osteoarthritis (OA) knee pain. We undertook this study to identify osteochondral pathologies specifically associated with... Read More about Associations of symptomatic knee OA with histopathologic features in subchondral bone.

Discrete trajectories of resolving and persistent pain in people with rheumatoid arthritis despite undergoing treatment for inflammation: results from three UK cohorts (2019)
Journal Article
McWilliams, D. F., Dawson, O., Young, A., Kiely, P., Ferguson, E., & Walsh, D. A. (2019). Discrete trajectories of resolving and persistent pain in people with rheumatoid arthritis despite undergoing treatment for inflammation: results from three UK cohorts. Journal of Pain, 20(6), 716-727. https://doi.org/10.1016/j.jpain.2019.01.001

Rheumatoid arthritis (RA) is an example of human chronic inflammatory pain. Modern treatments suppress inflammation, yet pain remains a major problem for many people with RA. We hypothesised that discrete RA subgroups might display favourable or unfa... Read More about Discrete trajectories of resolving and persistent pain in people with rheumatoid arthritis despite undergoing treatment for inflammation: results from three UK cohorts.

Bidirectional association between disturbed sleep and neuropathic pain symptoms: a prospective cohort study in post-total joint replacement participants (2018)
Journal Article
Stocks, J., Tang, N. K., Walsh, D. A., Warner, S. C., Harvey, H., Jenkins, W., …Valdes, A. M. (2018). Bidirectional association between disturbed sleep and neuropathic pain symptoms: a prospective cohort study in post-total joint replacement participants. Journal of Pain Research, 2018(11), 1087—1093. https://doi.org/10.2147/JPR.S149830

Disturbed sleep is strongly correlated with chronic pain. The aim of this study was to examine the association between sleep disturbance and incident joint pain focusing on neuropathic pain-like symptoms. 423 individuals who had undergone total joint... Read More about Bidirectional association between disturbed sleep and neuropathic pain symptoms: a prospective cohort study in post-total joint replacement participants.

A clinical assessment tool to improve the use of pain relieving treatments in knee osteoarthritis (2018)
Presentation / Conference Contribution
Akin-Akinyosoye, K., Frowd, N., Marshall, L., Stocks, J., Fernandes, G., Valdes, A., McWilliams, D., Zhang, W., Doherty, M., Ferguson, E., & Walsh, D. (2018, April). A clinical assessment tool to improve the use of pain relieving treatments in knee osteoarthritis. Presented at 2018 OARSI World Congress on Osteoarthritis : Promoting Clinical and Basic Research in Osteoarthritis, Liverpool, United Kingdom

Purpose: Approximately 1 in 4 individuals in the UK over the age of 55 experience knee pain (KP), predominantly due to osteoarthritis (OA). Following treatment targeted at the affected knee, pain relief is reported in only 60%–80% of individuals with... Read More about A clinical assessment tool to improve the use of pain relieving treatments in knee osteoarthritis.

General and disease-specific pain trajectories as predictors of social and political outcomes in arthritis and cancer (2018)
Journal Article
James, R. J. E., Walsh, D. A., & Ferguson, E. (2018). General and disease-specific pain trajectories as predictors of social and political outcomes in arthritis and cancer. BMC Medicine, 16, Article 51. https://doi.org/10.1186/s12916-018-1031-9

Background: While the heterogeniety of pain progression has been studied in chronic diseases, it is unclear the extent to which patterns of pain progression among people in general as well as across different diseases impacts on social, civic and po... Read More about General and disease-specific pain trajectories as predictors of social and political outcomes in arthritis and cancer.

Interpretation of DAS28 and its components in the assessment of inflammatory and non-inflammatory aspects of rheumatoid arthritis (2018)
Journal Article
McWilliams, D. F., Kiely, P. D., Young, A., Joharatnam, N., Wilson, D., & Walsh, D. A. (in press). Interpretation of DAS28 and its components in the assessment of inflammatory and non-inflammatory aspects of rheumatoid arthritis. BMC Rheumatology, 2(8), https://doi.org/10.1186/s41927-018-0016-9

Background: DAS28 is interpreted as the inflammatory disease activity of RA. Non-inflammatory pain mechanisms can confound assessment. We aimed to examine the use of DAS28 components or DAS28-derived measures that have been published as indices of no... Read More about Interpretation of DAS28 and its components in the assessment of inflammatory and non-inflammatory aspects of rheumatoid arthritis.

Pain mechanisms in rheumatoid arthritis (2017)
Journal Article
McWilliams, D. F., & Walsh, D. A. (2017). Pain mechanisms in rheumatoid arthritis. Clinical and Experimental Rheumatology, 35(S107), Article s94-s101

Understanding of the causes and underlying mechanisms of pain in people with RA is rapidly changing. With the advent of more effective disease modifying drugs, joint inflammation is becoming a more treatable cause of pain, and joint damage can often... Read More about Pain mechanisms in rheumatoid arthritis.

New therapeutic targets for osteoarthritis pain (2017)
Journal Article
Walsh, D. A., & Stocks, J. (2017). New therapeutic targets for osteoarthritis pain. Slas Discovery, 22(8), https://doi.org/10.1177/2472555217716912

Osteoarthritis (OA), the most common form of arthritis, causes pain and disability, as well as emotional distress. While total joint replacement is one of the most effective treatments available for improving the quality of life in people with severe... Read More about New therapeutic targets for osteoarthritis pain.

Pain in knee osteoarthritis is associated with variation in the neurokinin 1/substance P receptor (TACR 1) gene (2017)
Journal Article
Warner, S., Walsh, D. A., Laslett, L., Maciewicz, R., Soni, A., Hart, D., …Valdes, A. M. (2017). Pain in knee osteoarthritis is associated with variation in the neurokinin 1/substance P receptor (TACR 1) gene. European Journal of Pain, 21(7), 1277-1284. https://doi.org/10.1002/ejp.1027

Background: Substance P (SP) is a pain- and inflammation-related neuropeptide which preferentially binds to the neurokinin receptor 1 (NK1). SP and NK1 receptors have been implicated in joint pain, inflammation and damage in animal models and human s... Read More about Pain in knee osteoarthritis is associated with variation in the neurokinin 1/substance P receptor (TACR 1) gene.

Reductions in radiographic progression in early RA over 25-years: changing contribution from RF in 2 multi-centre UK inception cohorts (2017)
Journal Article
Carpenter, L., Norton, S., Nikiphorou, E., Jayakumar, K., McWilliams, D. F., Rennie, K. L., …Young, A. (2017). Reductions in radiographic progression in early RA over 25-years: changing contribution from RF in 2 multi-centre UK inception cohorts. Arthritis Care and Research, 69(12), 1809-1817. https://doi.org/10.1002/acr.23217

Objectives: To assess 5-year progression of erosions and Joint Space Narrowing (JSN), and their associations with RF status in two large, multi-centre early-RA cohorts spanning 25-years. Methods: Radiographic joint damage was recorded using the Sh... Read More about Reductions in radiographic progression in early RA over 25-years: changing contribution from RF in 2 multi-centre UK inception cohorts.

Pain prediction by serum biomarkers of bone turnover in people with knee osteoarthritis: an observational study of TRAcP5b and cathepsin K in OA (2017)
Journal Article
Nwosu, L. N., Allen, M., Wyatt, L., Huebner, J., Chapman, V., Walsh, D. A., & Kraus, V. (2017). Pain prediction by serum biomarkers of bone turnover in people with knee osteoarthritis: an observational study of TRAcP5b and cathepsin K in OA. Osteoarthritis and Cartilage, 25(6), https://doi.org/10.1016/j.joca.2017.01.002

Objectives: To investigate serum biomarkers, tartrate resistant acid phosphatase 5b (TRAcP5b) and cathepsin K, indicative of osteoclastic bone resorption, and their relationship to pain and pain change in knee osteoarthritis (OA). Methods: Sera and... Read More about Pain prediction by serum biomarkers of bone turnover in people with knee osteoarthritis: an observational study of TRAcP5b and cathepsin K in OA.

Discordant inflammation and pain in early and established rheumatoid arthritis: Latent Class Analysis of Early Rheumatoid Arthritis Network and British Society for Rheumatology Biologics Register data (2016)
Journal Article
McWilliams, D. F., Ferguson, E., Young, A., Kiely, P. D., & Walsh, D. A. (2016). Discordant inflammation and pain in early and established rheumatoid arthritis: Latent Class Analysis of Early Rheumatoid Arthritis Network and British Society for Rheumatology Biologics Register data. Arthritis Research and Therapy, 18(1), Article 295. https://doi.org/10.1186/s13075-016-1186-8

Background Rheumatoid arthritis (RA) disease activity is often measured using the 28 joint Disease Activity Score (DAS28). We aimed to identify and independently verify subgroups of people with RA that may be discordant with respect to self-reported... Read More about Discordant inflammation and pain in early and established rheumatoid arthritis: Latent Class Analysis of Early Rheumatoid Arthritis Network and British Society for Rheumatology Biologics Register data.

Identifying placebo responders and predictors of response in osteoarthritis: a protocol for individual patient data meta-analysis (2016)
Journal Article
Fu, Y., Persson, M. S., Bhattacharya, A., Goh, S.-L., Stocks, J., van Middelkoop, M., …Zhang, W. (2016). Identifying placebo responders and predictors of response in osteoarthritis: a protocol for individual patient data meta-analysis. Systematic Reviews, 5(1), Article 183. https://doi.org/10.1186/s13643-016-0362-x

Background: The management of osteoarthritis (OA) is unsatisfactory, as most treatments are not clinically effective over placebo and most drugs have considerable side effects. On average, 75 % of the analgesic effect from OA treatments in clinical t... Read More about Identifying placebo responders and predictors of response in osteoarthritis: a protocol for individual patient data meta-analysis.

Factors predicting pain and early discontinuation of tumour necrosis factor-α-inhibitors in people with rheumatoid arthritis: results from the British society for rheumatology biologics register (2016)
Journal Article
McWilliams, D. F., & Walsh, D. A. (2016). Factors predicting pain and early discontinuation of tumour necrosis factor-α-inhibitors in people with rheumatoid arthritis: results from the British society for rheumatology biologics register. BMC Musculoskeletal Disorders, 17(1), Article 337. https://doi.org/10.1186/s12891-016-1192-7

Background: We examined pain levels in 2 cohorts assembled from the British Society for Rheumatology Biologics Register (BSRBR), and investigated which factors predicted Bodily Pain scores and discontinuation of TNFα-inhibitors. Method: Data were re... Read More about Factors predicting pain and early discontinuation of tumour necrosis factor-α-inhibitors in people with rheumatoid arthritis: results from the British society for rheumatology biologics register.

Relationship between structural pathology and pain behaviour in a model of osteoarthritis (OA) (2016)
Journal Article
Nwosu, L. N., Mapp, P. I., Chapman, V., & Walsh, D. A. (2016). Relationship between structural pathology and pain behaviour in a model of osteoarthritis (OA). Osteoarthritis and Cartilage, 24(11), 1910-1917. https://doi.org/10.1016/j.joca.2016.06.012

Objectives To address the hypothesis that different types of established OA pain behaviours have associations with different aspects of articular pathology, we investigated the relationship between structural knee joint pathology and pain behaviour... Read More about Relationship between structural pathology and pain behaviour in a model of osteoarthritis (OA).

Transient receptor potential canonical 5 (TRPC5) protects against pain and vascular inflammation in arthritis and joint inflammation (2016)
Journal Article
Alawi, K. M., Russell, F. A., Aubdool, A. A., Srivastava, S., Riffo-Vasquez, Y., Baldissera, L., …Brain, S. D. (2017). Transient receptor potential canonical 5 (TRPC5) protects against pain and vascular inflammation in arthritis and joint inflammation. Annals of the Rheumatic Diseases, 76(1), 252-260. https://doi.org/10.1136/annrheumdis-2015-208886

Objective: Transient receptor potential canonical 5 (TRPC5) is functionally expressed on a range of cells including fibroblast-like synoviocytes, which play an important role in arthritis. A role for TRPC5 in inflammation has not been previously show... Read More about Transient receptor potential canonical 5 (TRPC5) protects against pain and vascular inflammation in arthritis and joint inflammation.