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All Outputs (65)

Neuropathic-like knee pain and associated risk factors: a cross-sectional study in a UK community sample (2018)
Journal Article
Fernandes, G. S., Valdes, A. M., Walsh, D. A., Zhang, W., & Doherty, M. (2018). Neuropathic-like knee pain and associated risk factors: a cross-sectional study in a UK community sample. Arthritis Research and Therapy, 20(1), Article 215. https://doi.org/10.1186/s13075-018-1717-6

Background

Neuropathic-like knee pain (NKP) is often reported in individuals with knee pain (KP), but the contribution of specific central and peripheral risk factors to NKP has not been studied previously. The aims of the present study were to de... Read More about Neuropathic-like knee pain and associated risk factors: a cross-sectional study in a UK community sample.

Contribution of central and peripheral risk factors to prevalence, incidence and progression of knee pain: a community-based cohort study (2018)
Journal Article
Sarmanova, A., Fernandes, G., Richardson, H., Valdes, A., Walsh, D., Zhang, W., & Doherty, M. (2018). Contribution of central and peripheral risk factors to prevalence, incidence and progression of knee pain: a community-based cohort study. Osteoarthritis and Cartilage, 26(11), 1461-1473. https://doi.org/10.1016/j.joca.2018.07.013

Aim

To explore risk factors that may influence knee pain (KP) through central or peripheral mechanisms.

Methods

A questionnaire-based prospective community cohort study with KP defined as pain in or around a knee on most days for at least a... Read More about Contribution of central and peripheral risk factors to prevalence, incidence and progression of knee pain: a community-based cohort study.

Prediction of persistent knee pain by pressure pain detection thresholds: results from the Knee Pain In the Community cohort (KPIC) (2018)
Presentation / Conference Contribution
McWilliams, D. F., Frowd, N., Marshall, L., Stocks, J., Sarmanova, A., Fernandes, G. S., Hall, M. C., Zhang, W., Doherty, M., & Walsh, D. A. Prediction of persistent knee pain by pressure pain detection thresholds: results from the Knee Pain In the Community cohort (KPIC). Presented at EULAR 2018 (Annual European Congress of Rheumatology)

Background:
Knee pain results from a combination of nociceptive input from the joint, and processing by the central nervous system. Pressure pain detection thresholds (PPTs) are lower and pain is more severe in people with greater central sensitisat... Read More about Prediction of persistent knee pain by pressure pain detection thresholds: results from the Knee Pain In the Community cohort (KPIC).

General and disease-specific pain trajectories as predictors of social and political outcomes in arthritis and cancer (2018)
Journal Article
James, R. J. E., Walsh, D. A., & Ferguson, E. (2018). General and disease-specific pain trajectories as predictors of social and political outcomes in arthritis and cancer. BMC Medicine, 16, Article 51. https://doi.org/10.1186/s12916-018-1031-9

Background:
While the heterogeniety of pain progression has been studied in chronic diseases, it is unclear the extent to which patterns of pain progression among people in general as well as across different diseases impacts on social, civic and po... Read More about General and disease-specific pain trajectories as predictors of social and political outcomes in arthritis and cancer.

Interpretation of DAS28 and its components in the assessment of inflammatory and non-inflammatory aspects of rheumatoid arthritis (2018)
Journal Article
McWilliams, D. F., Kiely, P. D., Young, A., Joharatnam, N., Wilson, D., & Walsh, D. A. (in press). Interpretation of DAS28 and its components in the assessment of inflammatory and non-inflammatory aspects of rheumatoid arthritis. BMC Rheumatology, 2(8), https://doi.org/10.1186/s41927-018-0016-9

Background: DAS28 is interpreted as the inflammatory disease activity of RA. Non-inflammatory pain mechanisms can confound assessment. We aimed to examine the use of DAS28 components or DAS28-derived measures that have been published as indices of no... Read More about Interpretation of DAS28 and its components in the assessment of inflammatory and non-inflammatory aspects of rheumatoid arthritis.

Traits associated with central pain augmentation in the Knee Pain in the Community (KPIC) cohort (2018)
Journal Article
Akin-Akinyosoye, K., Frowd, N., Marshall, L., Stocks, J., Fernandes, G. S., Valdes, A. M., McWilliams, D. F., Zhang, W., Doherty, M., Ferguson, E., & Walsh, D. A. (2018). Traits associated with central pain augmentation in the Knee Pain in the Community (KPIC) cohort. PAIN, 159(6), 1035–1044. https://doi.org/10.1097/j.pain.0000000000001183

This study aimed to identify self-report correlates of central pain augmentation in individuals with knee pain. A subset of participants (n=420) in the Knee Pain and related health In the Community (KPIC) baseline survey undertook pressure pain thres... Read More about Traits associated with central pain augmentation in the Knee Pain in the Community (KPIC) cohort.

Association between ultrasound-detected synovitis and knee pain: a population-based case-control study with both cross-sectional and follow-up data (2017)
Journal Article
Sarmanova, A., Hall, M. C., Fernandes, G. S., Bhattacharya, A., Valdes, A. M., Walsh, D. A., Doherty, M., & Zhang, W. (in press). Association between ultrasound-detected synovitis and knee pain: a population-based case-control study with both cross-sectional and follow-up data. Arthritis Research and Therapy, 19(281), https://doi.org/10.1186/s13075-017-1486-7

Background: Recently an important role for synovial pathology in the initiation and progression of knee osteoarthritis (OA) has been emphasised. This study aimed to examine whether ultrasonographydetected synovial changes (USSCs) associate with knee... Read More about Association between ultrasound-detected synovitis and knee pain: a population-based case-control study with both cross-sectional and follow-up data.

Pain mechanisms in rheumatoid arthritis (2017)
Journal Article
McWilliams, D. F., & Walsh, D. A. (2017). Pain mechanisms in rheumatoid arthritis. Clinical and Experimental Rheumatology, 35(S107), Article s94-s101

Understanding of the causes and underlying mechanisms of pain in people with RA is rapidly changing. With the advent of more effective disease modifying drugs, joint inflammation is becoming a more treatable cause of pain, and joint damage can often... Read More about Pain mechanisms in rheumatoid arthritis.

Knee pain and related health in the community study (KPIC): a cohort study protocol (2017)
Journal Article
Fernandes, G. S., Sarmanova, A., Warner, S. C., Harvey, H., Akin-Akinyosoye, K., Richardson, H., Frowd, N., Marshall, L., Stocks, J., Hall, M., Valdes, A. M., Walsh, D. A., Zhang, W., & Doherty, M. (in press). Knee pain and related health in the community study (KPIC): a cohort study protocol. BMC Musculoskeletal Disorders, 18(404), https://doi.org/10.1186/s12891-017-1761-4

Background: The incidence, progression and related risk factors for recent-onset knee pain (KP) remain uncertain. This study aims to examine the natural history of KP including incidence and progression and to identify possible phenotypes and their a... Read More about Knee pain and related health in the community study (KPIC): a cohort study protocol.

Imaging Pain Relief in Osteoarthritis (IPRO): protocol of a double-blind randomised controlled mechanistic study assessing pain relief and prediction of duloxetine treatment outcome (2017)
Journal Article
Reckziegel, D., Bailey, H., Cottam, W. J., Tench, C. R., Mahajan, R. P., Walsh, D. A., Knaggs, R., & Auer, D. P. (in press). Imaging Pain Relief in Osteoarthritis (IPRO): protocol of a double-blind randomised controlled mechanistic study assessing pain relief and prediction of duloxetine treatment outcome. BMJ Open, 7(6), Article e014013. https://doi.org/10.1136/bmjopen-2016-014013

Introduction: Osteoarthritis (OA) pain is a major cause of long-term disability and chronic pain in the adult population. One in five patients does not receive satisfactory pain relief, which reflects the complexity of chronic pain and the current la... Read More about Imaging Pain Relief in Osteoarthritis (IPRO): protocol of a double-blind randomised controlled mechanistic study assessing pain relief and prediction of duloxetine treatment outcome.

New therapeutic targets for osteoarthritis pain (2017)
Journal Article
Walsh, D. A., & Stocks, J. (2017). New therapeutic targets for osteoarthritis pain. Slas Discovery, 22(8), https://doi.org/10.1177/2472555217716912

Osteoarthritis (OA), the most common form of arthritis, causes pain and disability, as well as emotional distress. While total joint replacement is one of the most effective treatments available for improving the quality of life in people with severe... Read More about New therapeutic targets for osteoarthritis pain.

Reductions in radiographic progression in early RA over 25-years: changing contribution from RF in 2 multi-centre UK inception cohorts (2017)
Journal Article
Carpenter, L., Norton, S., Nikiphorou, E., Jayakumar, K., McWilliams, D. F., Rennie, K. L., Dixey, J., Kiely, P. D., Walsh, D. A., & Young, A. (2017). Reductions in radiographic progression in early RA over 25-years: changing contribution from RF in 2 multi-centre UK inception cohorts. Arthritis Care and Research, 69(12), 1809-1817. https://doi.org/10.1002/acr.23217

Objectives: To assess 5-year progression of erosions and Joint Space Narrowing (JSN), and their associations with RF status in two large, multi-centre early-RA cohorts spanning 25-years.

Methods: Radiographic joint damage was recorded using the Sh... Read More about Reductions in radiographic progression in early RA over 25-years: changing contribution from RF in 2 multi-centre UK inception cohorts.

Identifying placebo responders and predictors of response in osteoarthritis: a protocol for individual patient data meta-analysis (2016)
Journal Article
Fu, Y., Persson, M. S., Bhattacharya, A., Goh, S.-L., Stocks, J., van Middelkoop, M., Bierma-Zeinstra, S. M., Walsh, D., Doherty, M., & Zhang, W. (2016). Identifying placebo responders and predictors of response in osteoarthritis: a protocol for individual patient data meta-analysis. Systematic Reviews, 5(1), Article 183. https://doi.org/10.1186/s13643-016-0362-x

Background: The management of osteoarthritis (OA) is unsatisfactory, as most treatments are not clinically effective over placebo and most drugs have considerable side effects. On average, 75 % of the analgesic effect from OA treatments in clinical t... Read More about Identifying placebo responders and predictors of response in osteoarthritis: a protocol for individual patient data meta-analysis.

Histopathological subgroups in knee osteoarthritis (2016)
Journal Article
Wyatt, L., Morerton, B., Mapp, P. I., Wilson, D., Hill, R., Ferguson, E., Scammell, B. E., & Walsh, D. A. (in press). Histopathological subgroups in knee osteoarthritis. Osteoarthritis and Cartilage, 25(1), https://doi.org/10.1016/j.joca.2016.09.021

Objective: Osteoarthritis (OA) is a heterogeneous, multi-tissue disease. We hypothesised that different histopathological features characterise different stages during knee OA progression, and that discrete subgroups can be defined based on validated... Read More about Histopathological subgroups in knee osteoarthritis.

Factors predicting pain and early discontinuation of tumour necrosis factor-α-inhibitors in people with rheumatoid arthritis: results from the British society for rheumatology biologics register (2016)
Journal Article
McWilliams, D. F., & Walsh, D. A. (2016). Factors predicting pain and early discontinuation of tumour necrosis factor-α-inhibitors in people with rheumatoid arthritis: results from the British society for rheumatology biologics register. BMC Musculoskeletal Disorders, 17(1), Article 337. https://doi.org/10.1186/s12891-016-1192-7

Background: We examined pain levels in 2 cohorts assembled from the British Society for Rheumatology Biologics Register (BSRBR), and investigated which factors predicted Bodily Pain scores and discontinuation of TNFα-inhibitors.
Method: Data were re... Read More about Factors predicting pain and early discontinuation of tumour necrosis factor-α-inhibitors in people with rheumatoid arthritis: results from the British society for rheumatology biologics register.

Transient receptor potential canonical 5 (TRPC5) protects against pain and vascular inflammation in arthritis and joint inflammation (2016)
Journal Article
Alawi, K. M., Russell, F. A., Aubdool, A. A., Srivastava, S., Riffo-Vasquez, Y., Baldissera, L., Thakore, P., Saleque, N., Fernandes, E. S., Walsh, D. A., & Brain, S. D. (2017). Transient receptor potential canonical 5 (TRPC5) protects against pain and vascular inflammation in arthritis and joint inflammation. Annals of the Rheumatic Diseases, 76(1), 252-260. https://doi.org/10.1136/annrheumdis-2015-208886

Objective: Transient receptor potential canonical 5 (TRPC5) is functionally expressed on a range of cells including fibroblast-like synoviocytes, which play an important role in arthritis. A role for TRPC5 in inflammation has not been previously show... Read More about Transient receptor potential canonical 5 (TRPC5) protects against pain and vascular inflammation in arthritis and joint inflammation.

Selective inhibition of tropomyosin-receptor-kinase A (TrkA) reduces pain and joint damage in two rat models of inflammatory arthritis (2016)
Journal Article
Ashraf, S., Bouhana, K. S., Pheneger, J., Andrews, S. W., & Walsh, D. A. (2016). Selective inhibition of tropomyosin-receptor-kinase A (TrkA) reduces pain and joint damage in two rat models of inflammatory arthritis. Arthritis Research and Therapy, 18(1), https://doi.org/10.1186/s13075-016-0996-z

Background: Inflammation is an essential component of arthritis pain. Nerve growth factor (NGF) plays a key role in acute and chronic pain states especially those associated with inflammation. NGF acts through tropomyosin-receptor-kinase A (TrkA). NG... Read More about Selective inhibition of tropomyosin-receptor-kinase A (TrkA) reduces pain and joint damage in two rat models of inflammatory arthritis.

The measurement of psychological constructs in people with osteoarthritis of the knee: a psychometric evaluation (2016)
Journal Article
Lincoln, N., Moreton, B., Turner, K., & Walsh, D. A. (2017). The measurement of psychological constructs in people with osteoarthritis of the knee: a psychometric evaluation. Disability and Rehabilitation, 39(4), https://doi.org/10.3109/09638288.2016.1146356

Purpose: To examine the measurement properties of measures of psychological constructs in people with knee osteoarthritis.
Method: Participants with osteoarthritis of the knee completed the beck depression inventory (BDI-II), state-trait anxiety inv... Read More about The measurement of psychological constructs in people with osteoarthritis of the knee: a psychometric evaluation.

Home-administered pre-surgical psychological intervention for knee osteoarthritis (HAPPiKNEES): study protocol for a randomised controlled trial (2016)
Journal Article
das Nair, R., Anderson, P., Clarke, S. P., Leighton, P., Lincoln, N., Mhizha-Murira, J. R., Scammell, B. E., & Walsh, D. A. (2016). Home-administered pre-surgical psychological intervention for knee osteoarthritis (HAPPiKNEES): study protocol for a randomised controlled trial. Trials, 17(54), 1-11. https://doi.org/10.1186/s13063-016-1165-z

Background: Knee replacement surgery reduces pain for many people with osteoarthritis (OA). However, surgical outcomes are partly dependent on patients’ moods, and those with depression or anxiety have worse outcomes. Approximately one-third of peopl... Read More about Home-administered pre-surgical psychological intervention for knee osteoarthritis (HAPPiKNEES): study protocol for a randomised controlled trial.