All Outputs (2)

Profiling Allosteric Modulators of CB1R with an Allosteric Fluoroprobe (2025)
Journal Article
Carreira, E. M., Kosar, M., Perera, T., Ganzoni, R. L. Z., Sarott, R. C., Borrega-Roman, L., Vitale, R. M., Ligresti, A., Rufer, A. C., Guba, W., Grether, U., Veprintsev, D. B., & Sykes, D. A. (2025). Profiling Allosteric Modulators of CB1R with an Allosteric Fluoroprobe. Angewandte Chemie International Edition, 64(20), Article e202421885. https://doi.org/10.1002/anie.202421885

Allosteric modulation of cannabinoid receptor type 1 (CB1R) offers a promising alternative to conventional therapeutic approaches using orthosteric ligands (OLs). Currently, CB1R allosteric modulators (AMs) are characterized based on their ability to... Read More about Profiling Allosteric Modulators of CB1R with an Allosteric Fluoroprobe.

Structural basis of THC analog activity at the Cannabinoid 1 receptor (2025)
Journal Article
Thorsen, T. S., Kulkarni, Y., Sykes, D. A., Bøggild, A., Drace, T., Hompluem, P., Iliopoulos-Tsoutsouvas, C., Nikas, S. P., Daver, H., Makriyannis, A., Nissen, P., Gajhede, M., Veprintsev, D. B., Boesen, T., Kastrup, J. S., & Gloriam, D. E. (2025). Structural basis of THC analog activity at the Cannabinoid 1 receptor. Nature Communications, 16(1), Article 486. https://doi.org/10.1038/s41467-024-55808-4

Tetrahydrocannabinol (THC) is the principal psychoactive compound derived from the cannabis plant Cannabis sativa and approved for emetic conditions, appetite stimulation and sleep apnea relief. THC’s psychoactive actions are mediated primarily by th... Read More about Structural basis of THC analog activity at the Cannabinoid 1 receptor.