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Ex Vivo investigation of a Smart Endotracheal Tube for Identifying Oesophageal Intubation (2025)
Journal Article
Gadsby, B., Korposh, S., Correia, R., He, C., Hayes-Gill, B. R., Norris, A. M., Hardman, J. G., Hewson, D. W., & Morgan, S. P. (2025). Ex Vivo investigation of a Smart Endotracheal Tube for Identifying Oesophageal Intubation. Journal of Biomedical Optics, 30(6), Article 067003. https://doi.org/10.1117/1.JBO.30.6.067003

Significance
Unrecognized intubation of the esophagus instead of the trachea results in rapid and severe consequences for the patient. Utilizing the spectral properties of the tissues could reduce incidents of these events.

Aim
We aim to investi... Read More about Ex Vivo investigation of a Smart Endotracheal Tube for Identifying Oesophageal Intubation.

Core concepts in statistics and research methods. Part 2: clinical research principles and observational studies (2025)
Journal Article
Hewson, D. W., & Stuart, B. (2025). Core concepts in statistics and research methods. Part 2: clinical research principles and observational studies. BJA Education, 25(4), 146-154. https://doi.org/10.1016/j.bjae.2024.11.006

• Primary clinical research can be categorised as either observational or experimental.

• Bias is present in all observational studies.

•The relationship between an exposure and outcome can be distorted by a third extraneous variable, a confoun... Read More about Core concepts in statistics and research methods. Part 2: clinical research principles and observational studies.

The Role of Processed Electroencephalography in the Detection and Management of Acute Cerebral Ischemia: A Scoping Review (2025)
Journal Article
Hewson, D. W., Mankoo, A., Bath, P. M., Barley, M., Dhillon, P., Malik, L., & Krishnan, K. (2025). The Role of Processed Electroencephalography in the Detection and Management of Acute Cerebral Ischemia: A Scoping Review. Journal of Neurosurgical Anesthesiology, https://doi.org/10.1097/ANA.0000000000001018

Processed electroencephalography (pEEG) is increasingly used to titrate the depth of anesthesia. Whether such intra-procedural pEEG monitoring can offer additional information on cerebral perfusion or acute focal or global cerebral ischemia is unknow... Read More about The Role of Processed Electroencephalography in the Detection and Management of Acute Cerebral Ischemia: A Scoping Review.

Acute management of adults following chest wall injury: An assessment of institutional clinical practice guidelines across the UK and synthesis of care recommendations (2024)
Journal Article
Chen, C., Sehgal, A., Battle, C., Hardman, J., Ollivere, B., & Hewson, D. W. (2025). Acute management of adults following chest wall injury: An assessment of institutional clinical practice guidelines across the UK and synthesis of care recommendations. Injury, 56(5), Article 112077. https://doi.org/10.1016/j.injury.2024.112077

Objective
Chest wall injury causes significant morbidity and mortality. There is uncertainty regarding many aspects of clinical care for these patients, including optimal analgesia, acuity of monitoring and surgical fixation. Our aim in this work is... Read More about Acute management of adults following chest wall injury: An assessment of institutional clinical practice guidelines across the UK and synthesis of care recommendations.

Development and validation of metrics for assessment of ultrasound-guided fascial block skills (2024)
Journal Article
McLeod, G., Seeley, J., Wilson, M., Hind, D., Cole, A., Hewson, D., Hyslop, M., Keetharuth, A., MacFarlane, A., Wilby, M., McKendrick, M., McKendrick, G., Mustafa, A., Chuan, A., Bangalore, P. R., Record, N., Rombach, I., Sadler, A., Swaby, L., Taylor, A., & Tripathi, S. (2024). Development and validation of metrics for assessment of ultrasound-guided fascial block skills. British Journal of Anaesthesia, 133(4), 862-873. https://doi.org/10.1016/j.bja.2024.06.039

Background

As few anaesthetists provide lumbar erector spinae block for disc surgery, there is a need to provide training to enable a randomised controlled trial investigating analgesia after painful spinal surgery (NIHR153170). The primary object... Read More about Development and validation of metrics for assessment of ultrasound-guided fascial block skills.

Pain relief after instrumented spinal surgery (2024)
Presentation / Conference Contribution
Wilson, M. J., Cole, A., Hewson, D., Hind, D., Hawksworth, O., Hyslop, M., Keetharuth, A., Macfarlane, A., Martin, B., Mcleod, G., Rombach, I., Swaby, L., Tripathi, S., & Wilby, M. (2024, June). Pain relief after instrumented spinal surgery. Presented at The Society for Back Pain Research (SBPR) 2024 Annual General Meeting: “Innovation in Research and Management of Spine Pain”, Aberdeen, Scotland

Background

Over 55,000 spinal operations are performed annually in the NHS. Effective postoperative analgesia facilitates early mobilisation and assists rehabilitation and hospital discharge, but is difficult to achieve with conventional, opioid-b... Read More about Pain relief after instrumented spinal surgery.

Fabrication and assessment of a bio-inspired synthetic tracheal tissue model for tracheal tube cuff leakage testing (2024)
Journal Article
Agbiki, T., Arm, R., Hewson, D. W., Erdody, S., Norris, A. M., Correia, R., Korposh, S., Hayes-Gill, B. R., Shahidi, A., & Morgan, S. P. (2024). Fabrication and assessment of a bio-inspired synthetic tracheal tissue model for tracheal tube cuff leakage testing. BJA Open, 10, Article 100290. https://doi.org/10.1016/j.bjao.2024.100290

Introduction
Leakage of orogastric secretions past the cuff of a tracheal tube is a contributory factor in ventilator-associated pneumonia. Current bench test methods specified in the International Standard for Anaesthetic and Respiratory Equipment... Read More about Fabrication and assessment of a bio-inspired synthetic tracheal tissue model for tracheal tube cuff leakage testing.

Impact of spinal or epidural anaesthesia on perioperative outcomes in adult noncardiac surgery: a narrative review of recent evidence (2024)
Journal Article
Hewson, D. W., Tedore, T. R., & Hardman, J. G. (2024). Impact of spinal or epidural anaesthesia on perioperative outcomes in adult noncardiac surgery: a narrative review of recent evidence. British Journal of Anaesthesia, 133(2), 380-399. https://doi.org/10.1016/j.bja.2024.04.044

Spinal and epidural anaesthesia and analgesia are important anaesthetic techniques, familiar to all anaesthetists and applied to patients undergoing a range of surgical procedures. Although the immediate effects of a well-conducted neuraxial techniqu... Read More about Impact of spinal or epidural anaesthesia on perioperative outcomes in adult noncardiac surgery: a narrative review of recent evidence.

Effects of colour-coded compartmentalised syringe trays on anaesthetic drug error detection under cognitive load (2024)
Journal Article
Laxton, V., Maratos, F. A., Hewson, D. W., Baird, A., Archer, S., & Stupple, E. J. N. (2024). Effects of colour-coded compartmentalised syringe trays on anaesthetic drug error detection under cognitive load. British Journal of Anaesthesia, 132(5), 911-917. https://doi.org/10.1016/j.bja.2023.12.033

Background
Anaesthetic drug administration is complex, and typical clinical environments can entail significant cognitive load. Colour-coded anaesthetic drug trays have shown promising results for error identification and reducing cognitive load.... Read More about Effects of colour-coded compartmentalised syringe trays on anaesthetic drug error detection under cognitive load.

Regional analgesia for total hip arthroplasty and Schwartz's paradox (2023)
Journal Article
HEWSON, D., Macfarlane, A., & Scott, C. (2023). Regional analgesia for total hip arthroplasty and Schwartz's paradox. British Journal of Anaesthesia, 130(6), 650-654

Enhanced recovery after total hip arthroplasty aims to facilitate return to function and early hospital discharge, but the role of novel fascial plane block techniques in such pathways is uncertain. A randomised trial by Kukreja and colleagues descri... Read More about Regional analgesia for total hip arthroplasty and Schwartz's paradox.

Clinical hypnosis: implications in anaesthesia and perioperative care (2023)
Journal Article
Cyna, A. M., Hewson, D. W., & Hardman, J. G. (2023). Clinical hypnosis: implications in anaesthesia and perioperative care. British Journal of Anaesthesia, 130(6), 647-650

A randomised trial published in the British Journal of Anaesthesia describes hypnosis compared with general anaesthesia in 60 children undergoing superficial surgery. We describe a definition of clinical hypnosis; the goals and conduct of hypnotic co... Read More about Clinical hypnosis: implications in anaesthesia and perioperative care.

Closing the gap: artificial intelligence applied to ultrasound-guided regional anaesthesia (2023)
Journal Article
Hewson, D. W., & Bedforth, N. M. (2023). Closing the gap: artificial intelligence applied to ultrasound-guided regional anaesthesia. British Journal of Anaesthesia, 130(3), 245-247. https://doi.org/10.1016/j.bja.2022.12.005

The role of artificial intelligence in ultrasound-guided regional anaesthesia is explored in a recent study by Bowness and colleagues, published in the British Journal of Anaesthesia. The investigators showed that non-expert ability to identify key s... Read More about Closing the gap: artificial intelligence applied to ultrasound-guided regional anaesthesia.

Antiplatelet Resistance: A Review of Concepts, Mechanisms, and Implications for Management in Acute Ischemic Stroke and Transient Ischemic Attack (2023)
Journal Article
Krishnan, K., Nguyen, T. N., Appleton, J. P., Law, Z. K., Caulfied, M., Cabrera, C. P., Lenthall, R., Hewson, D., England, T., McConachie, N., Dhillon, P., Malik, L., Podlasek, A., Smith, C. J., Dawson, J., Robinson, T. G., Sprigg, N., James, M. A., White, P., Desborough, M. J., …Bath, P. M. (2023). Antiplatelet Resistance: A Review of Concepts, Mechanisms, and Implications for Management in Acute Ischemic Stroke and Transient Ischemic Attack. Stroke: Vascular and Interventional Neurology, 3(3), Article e000576. https://doi.org/10.1161/svin.122.000576

Acute ischemic stroke is a leading cause of death and major disability worldwide. Approximately 50% of ischemic strokes are caused by atherothrombotic occlusion of the cerebral arteries, and antiplatelets are the mainstay of secondary stroke preventa... Read More about Antiplatelet Resistance: A Review of Concepts, Mechanisms, and Implications for Management in Acute Ischemic Stroke and Transient Ischemic Attack.

Erector Spinae Plane Blocks for the Early Analgesia of Rib Fractures in Trauma (ESPEAR): protocol for a multicentre pilot randomised controlled trial with feasibility and embedded qualitative assessment (2022)
Journal Article
Hewson, D. W., Nightingale, J., Ogollah, R., Ollivere, B. J., Costa, M. L., Craxford, S., Bates, P., & Bedforth, N. M. (2022). Erector Spinae Plane Blocks for the Early Analgesia of Rib Fractures in Trauma (ESPEAR): protocol for a multicentre pilot randomised controlled trial with feasibility and embedded qualitative assessment. BMJ Open, 12(9), Article e062935. https://doi.org/10.1136/bmjopen-2022-062935

Introduction Patients with rib fractures commonly experience significant acute pain and are at risk of hypoxia, retained secretions, respiratory failure and death. Effective analgesia improves these outcomes. There is widespread variation in analgesi... Read More about Erector Spinae Plane Blocks for the Early Analgesia of Rib Fractures in Trauma (ESPEAR): protocol for a multicentre pilot randomised controlled trial with feasibility and embedded qualitative assessment.

Association between anesthesia modality and clinical outcomes following endovascular stroke treatment in the extended time window (2022)
Journal Article
Dhillon, P. S., Butt, W., Podlasek, A., McConachie, N., Lenthall, R., Nair, S., Malik, L., Hewson, D. W., Bhogal, P., Makalanda, H. L. D., James, M. A., Dineen, R. A., & England, T. J. (2023). Association between anesthesia modality and clinical outcomes following endovascular stroke treatment in the extended time window. Journal of NeuroInterventional Surgery, 15(5), 478-482. https://doi.org/10.1136/neurintsurg-2022-018846

Background: There is a paucity of data on anesthesia-related outcomes for endovascular treatment (EVT) in the extended window (>6 hours from ischemic stroke onset). We compared functional and safety outcomes between local anesthesia (LA) without seda... Read More about Association between anesthesia modality and clinical outcomes following endovascular stroke treatment in the extended time window.

Pressor therapy in acute ischaemic stroke: an updated systematic review (2022)
Journal Article
Strømsnes, T. A., Jørgen, T., Hagen, K., Ouyang, M., Wang, X., Chen, C., Rygg, S.-E., Hewson, D., Lenthall, R., Mcconachie, N., Izzath, W., Bath, P. M., Dhillon, P. S., Podlasek, A., England, T., Sprigg, N., Robinson, T. G., Advani, R., Ihle-Hansen, H., Sandset, E. C., & Krishnan, K. (2022). Pressor therapy in acute ischaemic stroke: an updated systematic review. European Stroke Journal, 7(2), 99-116. https://doi.org/10.1177/23969873221078136

Background:
Low blood pressure (BP) in acute ischaemic stroke (AIS) is associated with poor functional outcome, death, or severe disability. Increasing BP might benefit patients with post-stroke hypotension including those with potentially salvagea... Read More about Pressor therapy in acute ischaemic stroke: an updated systematic review.

Patient-maintained versus anaesthetist-controlled propofol sedation during elective primary lower-limb arthroplasty performed under spinal anaesthesia: a randomised controlled trial (2021)
Journal Article
Hewson, D. W., Worcester, F., Sprinks, J., Smith, M. D., Buchanan, H., Breedon, P., Hardman, J. G., & Bedforth, N. M. (2022). Patient-maintained versus anaesthetist-controlled propofol sedation during elective primary lower-limb arthroplasty performed under spinal anaesthesia: a randomised controlled trial. British Journal of Anaesthesia, 128(1), 186-197. https://doi.org/10.1016/j.bja.2021.09.038

Background: Patient-maintained propofol TCI sedation (PMPS) allows patients to titrate their own target-controlled infusion (TCI) delivery of propofol sedation using a handheld button. The aim of this RCT was to compare PMPS with anaesthetist-control... Read More about Patient-maintained versus anaesthetist-controlled propofol sedation during elective primary lower-limb arthroplasty performed under spinal anaesthesia: a randomised controlled trial.