The KDM5B and KDM1A lysine demethylases cooperate in regulating androgen receptor expression and signalling in prostate cancer

Metzler, Veronika M.; de Brot, Simone; Haigh, Daisy B.; Woodcock, Corinne L.; Lothion-Roy, Jennifer; Harris, Anna E.; Nilsson, Emeli M.; Ntekim, Atara; Persson, Jenny L.; Robinson, Brian D.; Khani, Francesca; Laursen, Kristian B.; Gudas, Lorraine J.; Toss, Michael S.; Madhusudan, Srinivasan; Rakha, Emad; Heery, David M.; Rutland, Catrin S.; Mongan, Nigel P.; Jeyapalan, Jennie N.

doi:10.3389/fcell.2023.1116424

All Outputs (2)

Sex-specific attenuation of constant light-induced memory impairment and Clock gene expression in brain in hepatic Npas2 knockout mice (2025)
Journal Article
Chrisp, R., Masterson, M., Pope, R., Roberts, C. J., Collins, H. M., Watson, D. J., O’Neil, D., Aagaard, K. M., Gibson, C. L., Heery, D. M., & Moran, P. M. (2025). Sex-specific attenuation of constant light-induced memory impairment and Clock gene expression in brain in hepatic Npas2 knockout mice. Scientific Reports, 15(1), Article 8347. https://doi.org/10.1038/s41598-025-92938-1

NPAS2 (Neuronal PAS Domain Protein 2) is a component of the core circadian clock and the coordinated activity between central brain and peripheral liver clock proteins postulated to be instrumental for linking behaviour and metabolism. We investigate... Read More about Sex-specific attenuation of constant light-induced memory impairment and Clock gene expression in brain in hepatic Npas2 knockout mice.

The KDM5B and KDM1A lysine demethylases cooperate in regulating androgen receptor expression and signalling in prostate cancer (2023)
Journal Article
Metzler, V. M., de Brot, S., Haigh, D. B., Woodcock, C. L., Lothion-Roy, J., Harris, A. E., Nilsson, E. M., Ntekim, A., Persson, J. L., Robinson, B. D., Khani, F., Laursen, K. B., Gudas, L. J., Toss, M. S., Madhusudan, S., Rakha, E., Heery, D. M., Rutland, C. S., Mongan, N. P., & Jeyapalan, J. N. (2023). The KDM5B and KDM1A lysine demethylases cooperate in regulating androgen receptor expression and signalling in prostate cancer. Frontiers in Cell and Developmental Biology, 11, Article 1116424. https://doi.org/10.3389/fcell.2023.1116424

Histone H3 lysine 4 (H3K4) methylation is key epigenetic mark associated with active transcription and is a substrate for the KDM1A/LSD1 and KDM5B/JARID1B lysine demethylases. Increased expression of KDM1A and KDM5B is implicated in many cancer types... Read More about The KDM5B and KDM1A lysine demethylases cooperate in regulating androgen receptor expression and signalling in prostate cancer.