All Outputs (42)

Temporal Trends in Equine Sperm Motility and Semen Volume: A Retrospective Analysis from a Single UK Breeding Facility (2024)
Journal Article
Harris, I. T., Nankervis, K., Pyatt, A., Gardner, D. S., Humphreys, P., & Blanchard, R. N. (2024). Temporal Trends in Equine Sperm Motility and Semen Volume: A Retrospective Analysis from a Single UK Breeding Facility. International Journal of Equine Science, 3(2), 100-106

The equine industry preferentially selects sires based on pedigree, performance, and conformation, with little concern given to fertility. Increasing evidence supports the theory of geographic-sensitive declines in a range of semen quality parameters... Read More about Temporal Trends in Equine Sperm Motility and Semen Volume: A Retrospective Analysis from a Single UK Breeding Facility.

Scoping review exploring the evidence base on Vitis vinifera toxicity in dogs after ingestion: Clinical effects, treatments and types of V. vinifera (2024)
Journal Article
Downs, J., Zoltowska, A., Hackney, T., Gardner, D. S., Ashmore, A., & Brennan, M. L. (2024). Scoping review exploring the evidence base on Vitis vinifera toxicity in dogs after ingestion: Clinical effects, treatments and types of V. vinifera. Veterinary Record, https://doi.org/10.1002/vetr.4536

Background
Treatment of Vitis vinifera fruit (VVF) ingestion can be challenging due to no clear toxic dose, signalment factors and variable clinical signs. Current treatment guidance is generalised: decontamination, aggressive fluid therapy, monitor... Read More about Scoping review exploring the evidence base on Vitis vinifera toxicity in dogs after ingestion: Clinical effects, treatments and types of V. vinifera.

Exploring the evidence base on grape (Vitis vinifera; VV) toxicity in dogs after ingestion - clinical effects, treatments, and types of VV fruit (VVF) implicated: A scoping review (2024)
Presentation / Conference Contribution
Downs, J., Zoltowska, A., Hackney, T., Gardner, D., Ashmore, A., & Brennan, M. (2024, March). Exploring the evidence base on grape (Vitis vinifera; VV) toxicity in dogs after ingestion - clinical effects, treatments, and types of VV fruit (VVF) implicated: A scoping review. Presented at BSAVA Congress 2024, Manchester, UK

Cardiovascular Fitness and Stride Acceleration in Race-Pace Workouts for the Prediction of Performance in Thoroughbreds (2024)
Journal Article
Schrurs, C., Dubois, G., Van Erck-Westergren, E., & Gardner, D. S. (2024). Cardiovascular Fitness and Stride Acceleration in Race-Pace Workouts for the Prediction of Performance in Thoroughbreds. Animals, 14(9), Article 1342. https://doi.org/10.3390/ani14091342

In-training racehorse physiological data can be leveraged to further explore race-day performance prediction. To date, no large retrospective, observational study has analysed whether in-training speed and heart rate recovery can predict racehorse su... Read More about Cardiovascular Fitness and Stride Acceleration in Race-Pace Workouts for the Prediction of Performance in Thoroughbreds.

Locomotory Profiles in Thoroughbreds: Peak Stride Length and Frequency in Training and Association with Race Outcomes (2022)
Journal Article
Schrurs, C., Blott, S., Dubois, G., Van Erck-Westergren, E., & Gardner, D. S. (2022). Locomotory Profiles in Thoroughbreds: Peak Stride Length and Frequency in Training and Association with Race Outcomes. Animals, 12(23), Article 3269. https://doi.org/10.3390/ani12233269

Racehorses competing in short (i.e., ‘sprinters’), middle- or longer-distance (i.e., ‘stayers’) flat races are assumed to have natural variation in locomotion; sprinters having an innately shorter stride than stayers. No study has objectively tested... Read More about Locomotory Profiles in Thoroughbreds: Peak Stride Length and Frequency in Training and Association with Race Outcomes.

Cryo-scanning electron microscopy demonstrates that ice morphology is not associated with the post-thaw survival of domestic boar (Sus domesticus) spermatozoa: A comparison of directional and conventional freezing methods (2022)
Journal Article
Gillis, J. D., Holt, W. V., Penfold, L. M., Woad, K. J., Graham, J. K., Watts, J. A., …Yon, L. (2022). Cryo-scanning electron microscopy demonstrates that ice morphology is not associated with the post-thaw survival of domestic boar (Sus domesticus) spermatozoa: A comparison of directional and conventional freezing methods. Cryobiology, 108, 10-18. https://doi.org/10.1016/j.cryobiol.2022.08.006

Directional freezing (in 2 or 10 ml hollow glass tubes) has been reported to improve post-thaw sperm survival parameters compared to conventional methods (in 0.5 ml straws). However, the biophysical properties that increase post-thaw survival are poo... Read More about Cryo-scanning electron microscopy demonstrates that ice morphology is not associated with the post-thaw survival of domestic boar (Sus domesticus) spermatozoa: A comparison of directional and conventional freezing methods.

Does sex of the jockey influence racehorse physiology and performance (2022)
Journal Article
Schrurs, C., Dubois, G., Van Erck-Westergren, E., & Gardner, D. S. (2022). Does sex of the jockey influence racehorse physiology and performance. PLoS ONE, 17(8), Article e0273310. https://doi.org/10.1371/journal.pone.0273310

The racing industry is supported by a predominance of female stablehands and work riders, but few become professional jockeys. Female jockeys have recently had notable race success. No study has assessed whether the sex of the rider may subtly influe... Read More about Does sex of the jockey influence racehorse physiology and performance.

Impact of COVID-19 on student attainment and pedagogical needs when undertaking independent scientific research (2022)
Journal Article
Jeyapalan, J. N., James, V., Gardner, D. S., Lothion-Roy, J. H., Mongan, N. P., & Rutland, C. S. (2022). Impact of COVID-19 on student attainment and pedagogical needs when undertaking independent scientific research. Anatomia, Histologia, Embryologia, https://doi.org/10.1111/ahe.12842

Research is often an essential component of completing a veterinary medicine degree, with universities worldwide aiming to teach students a variety of techniques and general research comprehension and skills. As universities worldwide navigated the C... Read More about Impact of COVID-19 on student attainment and pedagogical needs when undertaking independent scientific research.

Development and the Art of Nutritional Maintenance (2022)
Journal Article
Gardner, D. S., & Gray, C. (2022). Development and the Art of Nutritional Maintenance. British Journal of Nutrition, 1-24. https://doi.org/10.1017/S0007114522001490

Development from early conceptus to a complex, multi-cellular organism is a highly ordered process that is dependent on an adequate supply of nutrients. During this process, the pattern of organ growth is robust, driven by a genetic blueprint and mat... Read More about Development and the Art of Nutritional Maintenance.

Urinary Trace Elements Are Biomarkers for Early Detection of Acute Kidney Injury (2022)
Journal Article
Gardner, D. S., Allen, J. C., Goodson, D., Harvey, D., Sharman, A., Skinner, H., …Devonald, M. A. (2022). Urinary Trace Elements Are Biomarkers for Early Detection of Acute Kidney Injury. Kidney International Reports, 7(7), 1524-1538. https://doi.org/10.1016/j.ekir.2022.04.085

Introduction: Acute kidney injury (AKI) is common in hospitalized patients and associated with poor outcomes. Current methods for identifying AKI (rise in serum creatinine [sCr] or fall in urine output [UO]) are inadequate and delay detection. Early... Read More about Urinary Trace Elements Are Biomarkers for Early Detection of Acute Kidney Injury.

Intra-tracheal multiplexed sensing of contact pressure and perfusion (2021)
Journal Article
Correia, R., Gadsby, B., Korposh, S., Norris, A. M., Hayes-Gill, B. R., Sinha, R., …Morgan, S. P. (2022). Intra-tracheal multiplexed sensing of contact pressure and perfusion. Biomedical Optics Express, 13(1), 48-64. https://doi.org/10.1364/BOE.442165

Incorrect endotracheal tube (ETT) cuff inflation pressure causes significant problems for intubated patients. The technical development and first in vivo use of a smart ETT for measurements at the cuff-trachea interface during mechanical ventilation... Read More about Intra-tracheal multiplexed sensing of contact pressure and perfusion.

Increased Placental Cell Senescence and Oxidative Stress in Women with Pre-Eclampsia and Normotensive Post-Term Pregnancies (2021)
Journal Article
Scaife, P. J., Simpson, A., Kurlak, L. O., Briggs, L. V., Gardner, D. S., Pipkin, F. B., …Mistry, H. D. (2021). Increased Placental Cell Senescence and Oxidative Stress in Women with Pre-Eclampsia and Normotensive Post-Term Pregnancies. International Journal of Molecular Sciences, 22(14), Article 7295. https://doi.org/10.3390/ijms22147295

Up to 11% of pregnancies extend to post-term with adverse obstetric events linked to pregnancies over 42 weeks. Oxidative stress and senescence (cells stop growing and dividing by irreversibly arresting their cell cycle and gradually ageing) can resu... Read More about Increased Placental Cell Senescence and Oxidative Stress in Women with Pre-Eclampsia and Normotensive Post-Term Pregnancies.

Maternal protein restriction affects fetal ovary development in sheep (2021)
Journal Article
Nwachukwu, C. U., Woad, K. J., Barnes, N., Gardner, D. S., & Robinson, R. S. (2021). Maternal protein restriction affects fetal ovary development in sheep. Reproduction and Fertility, 2(2), 161-171. https://doi.org/10.1530/raf-20-0073

Maternal malnutrition has important developmental consequences for the foetus. Indeed, adverse fetal ovarian development could have lifelong impact, with potentially reduced ovarian reserve and fertility of the offspring. This study investigated the... Read More about Maternal protein restriction affects fetal ovary development in sheep.

SOX9 promotes stress-responsive transcription of VGF nerve growth factor inducible gene in renal tubular epithelial cells (2020)
Journal Article
Kim, J. Y., Bai, Y., Jayne, L. A., Abdulkader, F., Gandhi, M., Perreau, T., …Pabla, N. S. (2020). SOX9 promotes stress-responsive transcription of VGF nerve growth factor inducible gene in renal tubular epithelial cells. Journal of Biological Chemistry, 295(48), 16328-16341. https://doi.org/10.1074/jbc.RA120.015110

© 2020 Kim et al. Acute kidney injury (AKI) is a common clinical condition associated with diverse etiologies and abrupt loss of renal function. In patients with sepsis, rhabdomyolysis, cancer, and cardiovascular disorders, the underlying disease or... Read More about SOX9 promotes stress-responsive transcription of VGF nerve growth factor inducible gene in renal tubular epithelial cells.

Equine influenza vaccination as reported by horse owners and factors influencing their decision to vaccinate or not (2020)
Journal Article
Bambra, W., Daly, J. M., Kendall, N. R., Gardner, D. S., Brennan, M., & Kydd, J. H. (2020). Equine influenza vaccination as reported by horse owners and factors influencing their decision to vaccinate or not. Preventive Veterinary Medicine, 180, Article 105011. https://doi.org/10.1016/j.prevetmed.2020.105011

Background: Equine influenza virus is a highly contagious respiratory pathogen that causes pyrexia, anorexia, lethargy and coughing in immunologically naïve horses. Vaccines against equine influenza are available and vaccination is 20 mandatory for... Read More about Equine influenza vaccination as reported by horse owners and factors influencing their decision to vaccinate or not.

A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injury (2020)
Journal Article
Kim, J. Y., Bai, Y., Jayne, L. A., Hector, R. D., Persaud, A. K., Ong, S. S., …Pabla, N. S. (2020). A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injury. Nature Communications, 11(1), Article 1924. https://doi.org/10.1038/s41467-020-15638-6

© 2020, The Author(s). Renal tubular epithelial cells (RTECs) perform the essential function of maintaining the constancy of body fluid composition and volume. Toxic, inflammatory, or hypoxic-insults to RTECs can cause systemic fluid imbalance, elect... Read More about A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injury.

Definition of hourly urine output influences reported incidence and staging of acute kidney injury (2020)
Journal Article
Allen, J. C., Gardner, D. S., Skinner, H., Harvey, D., Sharman, A., & Devonald, M. A. (2020). Definition of hourly urine output influences reported incidence and staging of acute kidney injury. BMC Nephrology, 21(1), Article 19. https://doi.org/10.1186/s12882-019-1678-2

© 2020 The Author(s). Background: Acute kidney injury (AKI) is commonly defined using the KDIGO system, which includes criteria based on reduced urine output (UO). There is no consensus on whether UO should be measured using consecutive hourly readin... Read More about Definition of hourly urine output influences reported incidence and staging of acute kidney injury.

F1000Prime recommendation of Long-term outcomes following kidney transplantation from donors with acute kidney injury. (2019)
Data
Gardner, D. (2019). F1000Prime recommendation of Long-term outcomes following kidney transplantation from donors with acute kidney injury. [Dataset]. https://doi.org/10.3410/f.736024813.793561921

Mucosal injury following short term tracheal intubation: a novel animal model and composite injury score (2018)
Journal Article
Sinha, R., Correia, R., Gardner, D., Grau-Roma, L., de Brot, S., Hardman, J., Morgan, S., & Norris, A. (2018). Mucosal injury following short term tracheal intubation: a novel animal model and composite injury score. Laryngoscope Investigative Otolaryngology, 3(4), 257-262. https://doi.org/10.1002/lio2.168

Objectives: Postintubation laryngotracheal injury is common. Assessment of histopathological changes currently requires animal models. We set about developing a viable, resource effective animal model to study these effects and to develop a detailed... Read More about Mucosal injury following short term tracheal intubation: a novel animal model and composite injury score.

The dog as an animal model for bladder and urethral urothelial carcinoma: comparative epidemiology and histology (2018)
Journal Article
de Brot, S., Robinson, B. D., Scase, T., Grau‑Roma, L., Wilkinson, E., Boorjian, S. A., Gardner, D. S., & Mongan, N. P. (2018). The dog as an animal model for bladder and urethral urothelial carcinoma: comparative epidemiology and histology. Oncology Letters, 16(2), https://doi.org/10.3892/ol.2018.8837

Despite the recent approval of several novel agents for patients with metastatic urothelial carcinoma (UC), survival in this setting remains poor. As such, continued investigation into novel therapeutic options remains warranted. Pre clinical develop... Read More about The dog as an animal model for bladder and urethral urothelial carcinoma: comparative epidemiology and histology.