Definition of hourly urine output influences reported incidence and staging of acute kidney injury

Allen, Jennifer C.; Gardner, David S.; Skinner, Henry; Harvey, Daniel; Sharman, Andrew; Devonald, Mark A.J.

doi:10.1186/s12882-019-1678-2

All Outputs (5)

SOX9 promotes stress-responsive transcription of VGF nerve growth factor inducible gene in renal tubular epithelial cells (2020)
Journal Article
Kim, J. Y., Bai, Y., Jayne, L. A., Abdulkader, F., Gandhi, M., Perreau, T., Parikh, S. V., Gardner, D. S., Davidson, A. J., Sander, V., Song, M. A., Bajwa, A., & Pabla, N. S. (2020). SOX9 promotes stress-responsive transcription of VGF nerve growth factor inducible gene in renal tubular epithelial cells. Journal of Biological Chemistry, 295(48), 16328-16341. https://doi.org/10.1074/jbc.RA120.015110

© 2020 Kim et al. Acute kidney injury (AKI) is a common clinical condition associated with diverse etiologies and abrupt loss of renal function. In patients with sepsis, rhabdomyolysis, cancer, and cardiovascular disorders, the underlying disease or... Read More about SOX9 promotes stress-responsive transcription of VGF nerve growth factor inducible gene in renal tubular epithelial cells.

Equine influenza vaccination as reported by horse owners and factors influencing their decision to vaccinate or not (2020)
Journal Article
Bambra, W., Daly, J. M., Kendall, N. R., Gardner, D. S., Brennan, M., & Kydd, J. H. (2020). Equine influenza vaccination as reported by horse owners and factors influencing their decision to vaccinate or not. Preventive Veterinary Medicine, 180, Article 105011. https://doi.org/10.1016/j.prevetmed.2020.105011

Background: Equine influenza virus is a highly contagious respiratory pathogen that causes pyrexia, anorexia, lethargy and coughing in immunologically naïve horses. Vaccines against equine influenza are available and vaccination is 20 mandatory for... Read More about Equine influenza vaccination as reported by horse owners and factors influencing their decision to vaccinate or not.

A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injury (2020)
Journal Article
Kim, J. Y., Bai, Y., Jayne, L. A., Hector, R. D., Persaud, A. K., Ong, S. S., Rojesh, S., Raj, R., Feng, M. J. H. H., Chung, S., Cianciolo, R. E., Christman, J. W., Campbell, M. J., Gardner, D. S., Baker, S. D., Sparreboom, A., Govindarajan, R., Singh, H., Chen, T., Poi, M., …Pabla, N. S. (2020). A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injury. Nature Communications, 11(1), Article 1924. https://doi.org/10.1038/s41467-020-15638-6

© 2020, The Author(s). Renal tubular epithelial cells (RTECs) perform the essential function of maintaining the constancy of body fluid composition and volume. Toxic, inflammatory, or hypoxic-insults to RTECs can cause systemic fluid imbalance, elect... Read More about A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injury.

Renal accumulation of prooxidant mineral elements and CKD in domestic cats (2020)
Journal Article
Alborough, R., Grau-Roma, L., de Brot, S., Hantke, G., Vazquez, S., & Gardner, D. S. (2020). Renal accumulation of prooxidant mineral elements and CKD in domestic cats. Scientific Reports, 10(1), Article 3160. https://doi.org/10.1038/s41598-020-59876-6

Felids have a high incidence of chronic kidney disease (CKD), for which the most common renal lesion is chronic interstitial nephritis (CIN). CIN can be induced by tissue oxidative stress, which is determined by the cellular balance of pro- and anti-... Read More about Renal accumulation of prooxidant mineral elements and CKD in domestic cats.

Definition of hourly urine output influences reported incidence and staging of acute kidney injury (2020)
Journal Article
Allen, J. C., Gardner, D. S., Skinner, H., Harvey, D., Sharman, A., & Devonald, M. A. (2020). Definition of hourly urine output influences reported incidence and staging of acute kidney injury. BMC Nephrology, 21(1), Article 19. https://doi.org/10.1186/s12882-019-1678-2

© 2020 The Author(s). Background: Acute kidney injury (AKI) is commonly defined using the KDIGO system, which includes criteria based on reduced urine output (UO). There is no consensus on whether UO should be measured using consecutive hourly readin... Read More about Definition of hourly urine output influences reported incidence and staging of acute kidney injury.