All Outputs (6)

Deuterium brain imaging at 7T during D2O dosing (2022)
Journal Article
Cocking, D., Damion, R. A., Franks, H., Jaconelli, M., Wilkinson, D., Brook, M., …Bowtell, R. (2023). Deuterium brain imaging at 7T during D2O dosing. Magnetic Resonance in Medicine, 89(4), 1514-1521. https://doi.org/10.1002/mrm.29539

Purpose
To characterize the (2H) deuterium MR signal measured from human brain at 7T in participants loading with D2O to ˜1.5% enrichment over a six-week period.

Methods
2H spectroscopy and imaging measurements were used to track the time-course... Read More about Deuterium brain imaging at 7T during D2O dosing.

Effects of GLP-1 Infusion Upon Whole-body Glucose Uptake and Skeletal Muscle Perfusion During Fed-state in Older Men (2022)
Journal Article
Abdulla, H., Phillips, B., Wilkinson, D., Gates, A., Limb, M., Jandova, T., …Atherton, P. (2023). Effects of GLP-1 Infusion Upon Whole-body Glucose Uptake and Skeletal Muscle Perfusion During Fed-state in Older Men. Journal of Clinical Endocrinology and Metabolism, 108(4), 971-978. https://doi.org/10.1210/clinem/dgac613

Introduction
Ageing skeletal muscles become both insulin resistant and atrophic. The hormone glucagon-like peptide 1 (GLP-1) facilitates postprandial glucose uptake as well as augmenting muscle perfusion, independent of insulin action. We thus hypot... Read More about Effects of GLP-1 Infusion Upon Whole-body Glucose Uptake and Skeletal Muscle Perfusion During Fed-state in Older Men.

Caloric restriction improves glycaemic control without reducing plasma branched-chain amino acids or keto-acids in obese men (2022)
Journal Article
Sayda, M. H., Abdul-Aziz, M. H., Gharahdaghi, N., Wilkinson, D. J., Greenhaff, P. L., Philips, B. E., …Atherton, P. J. (2022). Caloric restriction improves glycaemic control without reducing plasma branched-chain amino acids or keto-acids in obese men. Scientific Reports, 12, Article 19273. https://doi.org/10.1038/s41598-022-21814-z

Higher plasma leucine, isoleucine and valine (BCAA) concentrations are associated with diabetes, obesity and insulin resistance (IR). Here, we evaluated the effects of 6-weeks very-low calorie diet (VLCD) upon fasting BCAA in overweight (OW) non-diab... Read More about Caloric restriction improves glycaemic control without reducing plasma branched-chain amino acids or keto-acids in obese men.

Motor unit dysregulation following 15 days of unilateral lower limb immobilisation (2022)
Journal Article
Inns, T. B., Bass, J. J., Hardy, E. J., Wilkinson, D. J., Stashuk, D. W., Atherton, P. J., …Piasecki, M. (2022). Motor unit dysregulation following 15 days of unilateral lower limb immobilisation. Journal of Physiology, 600(21), 4753-4769. https://doi.org/10.1113/jp283425

Abstract: Disuse atrophy, caused by situations of unloading such as limb immobilisation, causes a rapid yet diverging reduction in skeletal muscle function when compared to muscle mass. While mechanistic insight into the loss of mass is well studied,... Read More about Motor unit dysregulation following 15 days of unilateral lower limb immobilisation.

Declines in muscle protein synthesis account for short‐term muscle disuse atrophy in humans in the absence of increased muscle protein breakdown (2022)
Journal Article
Brook, M. S., Stokes, T., Gorissen, S. H., Bass, J. J., McGlory, C., Cegielski, J., …Atherton, P. J. (2022). Declines in muscle protein synthesis account for short‐term muscle disuse atrophy in humans in the absence of increased muscle protein breakdown. Journal of Cachexia, Sarcopenia and Muscle, 13(4), 2005-2016. https://doi.org/10.1002/jcsm.13005

Background: We determined the short-term (i.e. 4days) impacts of disuse atrophy in relation to muscle protein turnover [acute fasted-fed muscle protein synthesis (MPS)/muscle protein breakdown (MPB) and integrated MPS/estimated MPB]. Methods: Healthy... Read More about Declines in muscle protein synthesis account for short‐term muscle disuse atrophy in humans in the absence of increased muscle protein breakdown.

Neuromuscular recruitment strategies of the vastus lateralis according to sex (2022)
Journal Article
Guo, Y., Jones, E. J., Inns, T. B., Ely, I. A., Stashuk, D. W., Wilkinson, D. J., …Piasecki, M. (2022). Neuromuscular recruitment strategies of the vastus lateralis according to sex. Acta Physiologica, 235(2), Article e13803. https://doi.org/10.1111/apha.13803

Aim: Despite males typically exhibiting greater muscle strength and fatigability than females, it remains unclear if there are sex-based differences in neuromuscular recruitment strategies e.g. recruitment and modulation of motor unit firing rate (MU... Read More about Neuromuscular recruitment strategies of the vastus lateralis according to sex.