Angiogenesis in the synovium and at the osteochondral junction in osteoarthritis

Walsh, D. A.; Bonnet, C. S.; Turner, E. L.; Wilson, D.; Situ, M.; McWilliams, D. F.

doi:10.1016/j.joca.2007.01.020

Prediction of persistent knee pain by pressure pain detection thresholds: results from the Knee Pain In the Community cohort (KPIC) (2018)
Presentation / Conference Contribution
McWilliams, D. F., Frowd, N., Marshall, L., Stocks, J., Sarmanova, A., Fernandes, G. S., Hall, M. C., Zhang, W., Doherty, M., & Walsh, D. A. Prediction of persistent knee pain by pressure pain detection thresholds: results from the Knee Pain In the Community cohort (KPIC). Presented at EULAR 2018 (Annual European Congress of Rheumatology)

Background:
Knee pain results from a combination of nociceptive input from the joint, and processing by the central nervous system. Pressure pain detection thresholds (PPTs) are lower and pain is more severe in people with greater central sensitisat... Read More about Prediction of persistent knee pain by pressure pain detection thresholds: results from the Knee Pain In the Community cohort (KPIC).

Discordance between pain and inflammation in rheumatoid arthritis (2018)
Presentation / Conference Contribution
McWilliams, D. F. (2018, May). Discordance between pain and inflammation in rheumatoid arthritis. Paper presented at British Society for Rheumatology Annual Conference 2018, Liverpool. UK

Recent research interest has focused on the continuing problem of pain in RA. The long term prognosis for pain could be improved, even when inflammation is being suppressed. This talk will describe the progression of pain, and examine how factors oth... Read More about Discordance between pain and inflammation in rheumatoid arthritis.

Interpretation of DAS28 and its components in the assessment of inflammatory and non-inflammatory aspects of rheumatoid arthritis (2018)
Journal Article
McWilliams, D. F., Kiely, P. D., Young, A., Joharatnam, N., Wilson, D., & Walsh, D. A. (in press). Interpretation of DAS28 and its components in the assessment of inflammatory and non-inflammatory aspects of rheumatoid arthritis. BMC Rheumatology, 2(8), https://doi.org/10.1186/s41927-018-0016-9

Background: DAS28 is interpreted as the inflammatory disease activity of RA. Non-inflammatory pain mechanisms can confound assessment. We aimed to examine the use of DAS28 components or DAS28-derived measures that have been published as indices of no... Read More about Interpretation of DAS28 and its components in the assessment of inflammatory and non-inflammatory aspects of rheumatoid arthritis.

Traits associated with central pain augmentation in the Knee Pain in the Community (KPIC) cohort (2018)
Journal Article
Akin-Akinyosoye, K., Frowd, N., Marshall, L., Stocks, J., Fernandes, G. S., Valdes, A. M., …Walsh, D. A. (2018). Traits associated with central pain augmentation in the Knee Pain in the Community (KPIC) cohort. PAIN, 159(6), 1035–1044. https://doi.org/10.1097/j.pain.0000000000001183

This study aimed to identify self-report correlates of central pain augmentation in individuals with knee pain. A subset of participants (n=420) in the Knee Pain and related health In the Community (KPIC) baseline survey undertook pressure pain thres... Read More about Traits associated with central pain augmentation in the Knee Pain in the Community (KPIC) cohort.

Pain mechanisms in rheumatoid arthritis (2017)
Journal Article
McWilliams, D. F., & Walsh, D. A. (2017). Pain mechanisms in rheumatoid arthritis. Clinical and Experimental Rheumatology, 35(S107), Article s94-s101

Understanding of the causes and underlying mechanisms of pain in people with RA is rapidly changing. With the advent of more effective disease modifying drugs, joint inflammation is becoming a more treatable cause of pain, and joint damage can often... Read More about Pain mechanisms in rheumatoid arthritis.

Reductions in radiographic progression in early RA over 25-years: changing contribution from RF in 2 multi-centre UK inception cohorts (2017)
Journal Article
Carpenter, L., Norton, S., Nikiphorou, E., Jayakumar, K., McWilliams, D. F., Rennie, K. L., Dixey, J., Kiely, P. D., Walsh, D. A., & Young, A. (2017). Reductions in radiographic progression in early RA over 25-years: changing contribution from RF in 2 multi-centre UK inception cohorts. Arthritis Care and Research, 69(12), 1809-1817. https://doi.org/10.1002/acr.23217

Objectives: To assess 5-year progression of erosions and Joint Space Narrowing (JSN), and their associations with RF status in two large, multi-centre early-RA cohorts spanning 25-years.

Methods: Radiographic joint damage was recorded using the Sh... Read More about Reductions in radiographic progression in early RA over 25-years: changing contribution from RF in 2 multi-centre UK inception cohorts.

Responsiveness of SF-36 Health Survey and Patient Generated Index in people with chronic knee pain commenced on oral analgesia: analysis of data from a randomised controlled clinical trial (2016)
Journal Article
Papou, A., Hussain, S., McWilliams, D. F., Zhang, W., & Doherty, M. (in press). Responsiveness of SF-36 Health Survey and Patient Generated Index in people with chronic knee pain commenced on oral analgesia: analysis of data from a randomised controlled clinical trial. Quality of Life Research, https://doi.org/10.1007/s11136-016-1484-2

Purpose. (1) to assess the responsiveness of the Short Form 36 Health Survey (SF-36) and Patient Generated Index (PGI) in people with knee pain who were given oral analgesics; and (2) to perform content analysis of the SF-36 and PGI aiming to identif... Read More about Responsiveness of SF-36 Health Survey and Patient Generated Index in people with chronic knee pain commenced on oral analgesia: analysis of data from a randomised controlled clinical trial.

Discordant inflammation and pain in early and established rheumatoid arthritis: Latent Class Analysis of Early Rheumatoid Arthritis Network and British Society for Rheumatology Biologics Register data (2016)
Journal Article
McWilliams, D. F., Ferguson, E., Young, A., Kiely, P. D., & Walsh, D. A. (2016). Discordant inflammation and pain in early and established rheumatoid arthritis: Latent Class Analysis of Early Rheumatoid Arthritis Network and British Society for Rheumatology Biologics Register data. Arthritis Research and Therapy, 18(1), Article 295. https://doi.org/10.1186/s13075-016-1186-8

Background
Rheumatoid arthritis (RA) disease activity is often measured using the 28 joint Disease Activity Score (DAS28). We aimed to identify and independently verify subgroups of people with RA that may be discordant with respect to self-reported... Read More about Discordant inflammation and pain in early and established rheumatoid arthritis: Latent Class Analysis of Early Rheumatoid Arthritis Network and British Society for Rheumatology Biologics Register data.

Factors predicting pain and early discontinuation of tumour necrosis factor-α-inhibitors in people with rheumatoid arthritis: results from the British society for rheumatology biologics register (2016)
Journal Article
McWilliams, D. F., & Walsh, D. A. (2016). Factors predicting pain and early discontinuation of tumour necrosis factor-α-inhibitors in people with rheumatoid arthritis: results from the British society for rheumatology biologics register. BMC Musculoskeletal Disorders, 17(1), Article 337. https://doi.org/10.1186/s12891-016-1192-7

Background: We examined pain levels in 2 cohorts assembled from the British Society for Rheumatology Biologics Register (BSRBR), and investigated which factors predicted Bodily Pain scores and discontinuation of TNFα-inhibitors.
Method: Data were re... Read More about Factors predicting pain and early discontinuation of tumour necrosis factor-α-inhibitors in people with rheumatoid arthritis: results from the British society for rheumatology biologics register.

Erosive and osteoarthritic structural progression in early rheumatoid arthritis (2016)
Journal Article
McWilliams, D. F., Marshall, M., Jayakumar, K., Doherty, S., Doherty, M., Zhang, W., …Walsh, D. A. (2016). Erosive and osteoarthritic structural progression in early rheumatoid arthritis. Rheumatology, 55(8), 1477-1488. https://doi.org/10.1093/rheumatology/kew197

OBJECTIVES: To investigate factors associated with joint damage in early RA, and how comorbid OA might influence patient assessment and outcomes. METHODS: Baseline radiographs of hands and feet from 512 participants in the Early RA Network cohort, an... Read More about Erosive and osteoarthritic structural progression in early rheumatoid arthritis.

A cross-sectional study of pain sensitivity, disease-activity assessment, mental health, and fibromyalgia status in rheumatoid arthritis (2015)
Journal Article
Joharatnam, N., McWilliams, D. F., Wilson, D., Wheeler, M., Pande, I., & Walsh, D. A. (2015). A cross-sectional study of pain sensitivity, disease-activity assessment, mental health, and fibromyalgia status in rheumatoid arthritis. Arthritis Research and Therapy, 17(11), https://doi.org/10.1186/s13075-015-0525-5

INTRODUCTION: Pain remains the most important problem for people with rheumatoid arthritis (RA). Active inflammatory disease contributes to pain, but pain due to non-inflammatory mechanisms can confound the assessment of disease activity. We hypothes... Read More about A cross-sectional study of pain sensitivity, disease-activity assessment, mental health, and fibromyalgia status in rheumatoid arthritis.

Self-reported adult footwear and the risks of lower limb osteoarthritis: the GOAL case control study. (2014)
Journal Article
McWilliams, D. F., Muthuri, S., Muir, K. R., Maciewicz, R. A., Zhang, W., & Doherty, M. (2014). Self-reported adult footwear and the risks of lower limb osteoarthritis: the GOAL case control study. BMC Musculoskeletal Disorders, 15(1), https://doi.org/10.1186/1471-2474-15-308

Background: Biomechanical factors may play a role in osteoarthritis (OA) development and progression. Previous biomechanical studies have indicated that types of footwear may modulate forces across the knee joint, and high heeled womens' shoes in par... Read More about Self-reported adult footwear and the risks of lower limb osteoarthritis: the GOAL case control study..

Mechanisms, impact and management of pain in rheumatoid arthritis (2014)
Journal Article
Walsh, D. A., & McWilliams, D. F. (2014). Mechanisms, impact and management of pain in rheumatoid arthritis. Nature Reviews Rheumatology, 10(10), 581-592. https://doi.org/10.1038/nrrheum.2014.64

© 2014 Macmillan Publishers Limited. All rights reserved. People with rheumatoid arthritis (RA) identify pain as their most important symptom, one that often persists despite optimal control of inflammatory disease. RA pain arises from multiple mecha... Read More about Mechanisms, impact and management of pain in rheumatoid arthritis.

Work disability and state benefit claims in early rheumatoid arthritis: the ERAN cohort (2013)
Journal Article
McWilliams, D. F., Varughese, S., Young, A., Kiely, P. D., & Walsh, D. A. (2014). Work disability and state benefit claims in early rheumatoid arthritis: the ERAN cohort. Rheumatology, 53(3), 473-481. https://doi.org/10.1093/rheumatology/ket373

Objective. RA is an important cause of work disability. This study aimed to identify predictive factors for work disability and state benefit claims in a cohort with early RA.

Methods. The Early RA Network (ERAN) inception cohort recruited from 22... Read More about Work disability and state benefit claims in early rheumatoid arthritis: the ERAN cohort.

Baseline factors predicting change from the initial DMARD treatment during the first 2 years of rheumatoid arthritis: experience in the ERAN inception cohort (2013)
Journal Article
McWilliams, D. F., Kiely, P. D., Young, A., & Walsh, D. A. (2013). Baseline factors predicting change from the initial DMARD treatment during the first 2 years of rheumatoid arthritis: experience in the ERAN inception cohort. BMC Musculoskeletal Disorders, 14(May), Article 7. https://doi.org/10.1186/1471-2474-14-153

Background
Outcomes in early Rheumatoid Arthritis (RA) may be improved by rapidly establishing a stable and effective disease modifying anti-rheumatic drug (DMARD) treatment regimen. We aimed to investigate whether baseline factors and initial treat... Read More about Baseline factors predicting change from the initial DMARD treatment during the first 2 years of rheumatoid arthritis: experience in the ERAN inception cohort.

Pain in rheumatoid arthritis (2012)
Journal Article
Walsh, D. A., & McWilliams, D. F. (2012). Pain in rheumatoid arthritis. Current Pain and Headache Reports, 16(6), 509-517. https://doi.org/10.1007/s11916-012-0303-x

Rheumatoid arthritis (RA) is an inflammatory disease of synovial joints, and pain is the predominant problem for people with RA. Pain in RA is distressing in its own right and adversely affects disability and psychosocial outcomes. RA pain may be due... Read More about Pain in rheumatoid arthritis.

Quantitative sensory testing in painful osteoarthritis: A systematic review and meta-analysis (2012)
Journal Article
Suokas, A. K., Walsh, D. A., McWilliams, D. F., Condon, L., Moreton, B., Wylde, V., …Zhang, W. (2012). Quantitative sensory testing in painful osteoarthritis: A systematic review and meta-analysis. Osteoarthritis and Cartilage, 20(10), 1075-1085. https://doi.org/10.1016/j.joca.2012.06.009

Objective: To systematically review the use of Quantitative sensory testing (QST) in pain characterisation (phenotyping) in Osteoarthritis (OA). Methods: Six bibliographic databases (Medline, Embase, Amed, Cinahl, PubMed, Web of Science) were searche... Read More about Quantitative sensory testing in painful osteoarthritis: A systematic review and meta-analysis.

Predictors of change in bodily pain in early rheumatoid arthritis: an inception cohort study (2012)
Journal Article
McWilliams, D. F., Zhang, W., Mansell, J. S., Kiely, P. D., Young, A., & Walsh, D. A. (2012). Predictors of change in bodily pain in early rheumatoid arthritis: an inception cohort study. Arthritis Care and Research, 64(10), https://doi.org/10.1002/acr.21723

Objective: To investigate possible predictors for lack of pain improvement after 1 year of treatment for early rheumatoid arthritis (RA).

Methods: The Early Rheumatoid Arthritis Network (ERAN) database was used for analysis of baseline and 1-year... Read More about Predictors of change in bodily pain in early rheumatoid arthritis: an inception cohort study.

Lymphatic vessels in osteoarthritic human knees (2012)
Journal Article
Walsh, D. A., Verghese, P., Cook, G. J., McWilliams, D. F., Mapp, P. I., Ashraf, S., & Wilson, D. (2012). Lymphatic vessels in osteoarthritic human knees. Osteoarthritis and Cartilage, 20(5), 405-412. https://doi.org/10.1016/j.joca.2012.01.012

Objectives: The distribution and function of lymphatic vessels in normal and diseased human knees are understood incompletely. This study aimed to investigate whether lymphatic density is associated with clinical, histological or radiographic paramet... Read More about Lymphatic vessels in osteoarthritic human knees.

Angiogenesis in the synovium and at the osteochondral junction in osteoarthritis (2007)
Journal Article
Walsh, D. A., Bonnet, C. S., Turner, E. L., Wilson, D., Situ, M., & McWilliams, D. F. (2007). Angiogenesis in the synovium and at the osteochondral junction in osteoarthritis. Osteoarthritis and Cartilage, 15(7), 743-751. https://doi.org/10.1016/j.joca.2007.01.020

Objectives:
We hypothesised that osteochondral and synovial angiogenesis in osteoarthritis (OA) are independent processes. We investigated whether indices of osteochondral and synovial angiogenesis display different relationships with synovitis, di... Read More about Angiogenesis in the synovium and at the osteochondral junction in osteoarthritis.

All Outputs (68)