All Outputs (61)
The patient acceptable symptom state for knee pain - a systematic literature review and meta-analysis (2021)
Journal Article
Purpose: Knee pain is highly prevalent, most commonly attributed to osteoarthritis in older people, and in younger people often due to internal derangements. Knee pain can be measured using numerical patient-reported outcome measures (PROMs). Several... Read More about The patient acceptable symptom state for knee pain - a systematic literature review and meta-analysis.
The Central Aspects of Pain in the Knee (CAP-Knee) questionnaire; a mixed-methods study of a self-report instrument for assessing central mechanisms in people with knee pain (2021)
Journal Article
OBJECTIVES: Pain is the prevailing symptom of knee osteoarthritis. Central sensitisation creates discordance between pain and joint pathology. We previously reported a central pain mechanisms trait derived from 8 discrete characteristics: neuropathic... Read More about The Central Aspects of Pain in the Knee (CAP-Knee) questionnaire; a mixed-methods study of a self-report instrument for assessing central mechanisms in people with knee pain.
Association of subchondral bone marrow lesion localization with weight-bearing pain in people with knee osteoarthritis: data from the Osteoarthritis Initiative (2021)
Journal Article
© 2021, The Author(s). Background: Subchondral bone marrow lesions (BMLs) detected on MRI in knee osteoarthritis (OA) are associated with knee pain. The prevalence and progression of subchondral BMLs are increased by mechanical knee load. However, as... Read More about Association of subchondral bone marrow lesion localization with weight-bearing pain in people with knee osteoarthritis: data from the Osteoarthritis Initiative.
Contribution of nerves within osteochondral channels to osteoarthritis knee pain in humans and rats (2020)
Journal Article
© 2020 Osteoarthritis Research Society International Objectives: Subchondral bone may contribute to knee osteoarthritis (OA) pain. Nerve growth factor (NGF) can stimulate nerve growth through TrkA. We aimed to identify how sensory nerve growth at the... Read More about Contribution of nerves within osteochondral channels to osteoarthritis knee pain in humans and rats.
Pain distant from the index site and sensitization in people with knee pain and low back pain (2020)
Conference Proceeding
Investigating musculoskeletal health and wellbeing; A cohort study protocol (2020)
Journal Article
© 2020 The Author(s). Background: In an ageing population, pain, frailty and disability frequently coexist across a wide range of musculoskeletal diagnoses, but their associations remain incompletely understood. The Investigating Musculoskeletal Heal... Read More about Investigating musculoskeletal health and wellbeing; A cohort study protocol.
Baseline self-report ‘central mechanisms’ trait predicts persistent knee pain in the Knee Pain in the Community (KPIC) cohort (2019)
Journal Article
Objectives We investigated whether baseline scores for a self-report trait linked to central mechanisms predict 1 year pain outcomes in the Knee Pain in the Community cohort. Method 1471 participants reported knee pain at baseline and respon... Read More about Baseline self-report ‘central mechanisms’ trait predicts persistent knee pain in the Knee Pain in the Community (KPIC) cohort.
Baseline self-report ‘central mechanisms’ trait predicts persistent knee pain in the Knee Pain in the Community (KPIC) cohort (2019)
Journal Article
© 2019 The Authors Objectives: We investigated whether baseline scores for a self-report trait linked to central mechanisms predict 1 year pain outcomes in the Knee Pain in the Community cohort. METHOD: 1471 participants reported knee pain at baselin... Read More about Baseline self-report ‘central mechanisms’ trait predicts persistent knee pain in the Knee Pain in the Community (KPIC) cohort.
Disease Activity Flares and Pain Flares in an early rheumatoid arthritis inception cohort; characteristics, antecedents and sequelae (2019)
Journal Article
Background RA flares are common and disabling. They are described in terms of worsening inflammation but pain and inflammation are often discordant. To inform treatment decisions, we investigated whether inflammatory and pain flares are discrete ent... Read More about Disease Activity Flares and Pain Flares in an early rheumatoid arthritis inception cohort; characteristics, antecedents and sequelae.
PAIN AND FATIGUE IN EARLY RHEUMATOID ARTHRITIS - A CROSS-SECTIONAL STUDY (2019)
Presentation / Conference
O.S. Ifesemen, D.F. McWilliams, A. Young, P.D.W. Kiely, D.A. Walsh Background and Aims Pain and fatigue are prevalent and impair quality of life in people with Rheumatoid Arthritis (RA). They might be caused by multiple and overlapping mechanis... Read More about PAIN AND FATIGUE IN EARLY RHEUMATOID ARTHRITIS - A CROSS-SECTIONAL STUDY.
CGRP and painful pathologies other than headache (2019)
Book Chapter
© 2019, Springer Nature Switzerland AG. CGRP has long been suspected as a mediator of arthritis pain, although evidence that CGRP directly mediates human musculoskeletal pain remains circumstantial. This chapter describes in depth the evidence surrou... Read More about CGRP and painful pathologies other than headache.
Disease Activity Flares and Pain Flares in an early rheumatoid arthritis inception cohort; characteristics, antecedants and sequelae (2019)
Presentation / Conference
Background RA flares are common and disabling. They are described in terms of worsening pain, swelling, or other symptoms. We aimed to determine characteristics, antecedants and sequelae of painful and inflammatory flare subtypes during the first 11... Read More about Disease Activity Flares and Pain Flares in an early rheumatoid arthritis inception cohort; characteristics, antecedants and sequelae.
Self-report central mechanisms trait predicts knee pain persistence in the Knee Pain In the Community (KPIC) cohort (2019)
Presentation / Conference
Quantitative sensory testing and predicting outcomes for musculoskeletal pain, disability, and negative affect: a systematic review and meta-analysis (2019)
Journal Article
Hypersensitivity due to central pain mechanisms can influence recovery and lead to worse clinical outcomes, but the ability of quantitative sensory testing (QST), an index of sensitisation, to predict outcomes in chronic musculoskeletal disorders rem... Read More about Quantitative sensory testing and predicting outcomes for musculoskeletal pain, disability, and negative affect: a systematic review and meta-analysis.
Associations of symptomatic knee OA with histopathologic features in subchondral bone (2019)
Journal Article
© 2019, American College of Rheumatology Objective: Subchondral bone and the osteochondral junction are thought to contribute to osteoarthritis (OA) knee pain. We undertook this study to identify osteochondral pathologies specifically associated with... Read More about Associations of symptomatic knee OA with histopathologic features in subchondral bone.
Discrete trajectories of resolving and persistent pain in people with rheumatoid arthritis despite undergoing treatment for inflammation: results from three UK cohorts (2019)
Journal Article
Rheumatoid arthritis (RA) is an example of human chronic inflammatory pain. Modern treatments suppress inflammation, yet pain remains a major problem for many people with RA. We hypothesised that discrete RA subgroups might display favourable or unfa... Read More about Discrete trajectories of resolving and persistent pain in people with rheumatoid arthritis despite undergoing treatment for inflammation: results from three UK cohorts.
Analgesic effects of the cathepsin K inhibitor L-006235 in the monosodium iodoacetate model of osteoarthritis pain (2018)
Journal Article
© 2018 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The International Association for the Study of Pain. Introduction: The mounting evidence that osteoclasts play an important role in osteoarthritis (OA) pain lead us to invest... Read More about Analgesic effects of the cathepsin K inhibitor L-006235 in the monosodium iodoacetate model of osteoarthritis pain.