All Outputs (4)

Central aspects of pain associated with physical activity: results from the Investigating Musculoskeletal Health and Wellbeing cohort (2025)
Journal Article
Smith, S., Habib, M., Chaplin, W., Millar, B., McWilliams, D., & Walsh, D. (2025). Central aspects of pain associated with physical activity: results from the Investigating Musculoskeletal Health and Wellbeing cohort. PAIN Reports, 10(3), Article e1268. https://doi.org/10.1097/PR9.0000000000001268

Background:
Knee pain reduces activity, while inactivity can increase pain. The central nervous system modulates both pain and activity. The 8-item Central Aspects of Pain (CAP) questionnaire measures self-reported symptoms associated with current a... Read More about Central aspects of pain associated with physical activity: results from the Investigating Musculoskeletal Health and Wellbeing cohort.

Validity and contributions to pain severity from the Central Aspects of Pain (CAP) questionnaire in rheumatoid arthritis (2025)
Journal Article
Smith, S., Georgopoulos, V., Ifesemen, O., James, R., Ferguson, E., Wakefield, R., Wilson, D., Buckley, P., Platts, D., Ledbury, S., Choy, E., Pickles, T., Rutter-Locher, Z., Kirkham, B., Walsh, D., & McWilliams, D. (in press). Validity and contributions to pain severity from the Central Aspects of Pain (CAP) questionnaire in rheumatoid arthritis. PAIN Reports,

Background: The central nervous system (CNS) contributes to pain perception across musculoskeletal conditions. The Central Aspects of Pain (CAP) questionnaire captures a single score associated with quantitative sensory testing (QST) evidence of CNS... Read More about Validity and contributions to pain severity from the Central Aspects of Pain (CAP) questionnaire in rheumatoid arthritis.

The importance of central sensitization for clinical trials of Disease Modifying Osteoarthritis drugs (DMOADs) (2025)
Journal Article
Walsh, D. A., & McWilliams, D. F. (2025). The importance of central sensitization for clinical trials of Disease Modifying Osteoarthritis drugs (DMOADs). Osteoarthritis Imaging, 5(1), Article 100261. https://doi.org/10.1016/j.ostima.2025.100261

Osteoarthritis (OA) pain is associated with structural changes in the joint, which are usually quantified by imaging techniques. It is anticipated that structural disease modifying OA drugs (DMOADs) would reduce the burden of OA pain. However, nocice... Read More about The importance of central sensitization for clinical trials of Disease Modifying Osteoarthritis drugs (DMOADs).

Comparative effectiveness of various exercise interventions on central sensitisation indices: A systematic review and network meta-analysis (2025)
Journal Article
Ibrahim, A. A. E., McWilliams, D. F., Smith, S. L., Chaplin, W. J., Salimian, M., Georgopoulos, V., Kouraki, A., & Walsh, D. A. (2025). Comparative effectiveness of various exercise interventions on central sensitisation indices: A systematic review and network meta-analysis. Annals of Physical and Rehabilitation Medicine, 68(4), Article 101894. https://doi.org/10.1016/j.rehab.2024.101894

Background: Central sensitisation (CS) increases musculoskeletal pain. Quantitative sensory testing (QST) or self-report questionnaires might indicate CS. Indices of CS might be suppressed by exercise, although the optimal exercise regimen remains un... Read More about Comparative effectiveness of various exercise interventions on central sensitisation indices: A systematic review and network meta-analysis.