All Outputs (2)

The rat osteoarthritis bone score for histological pathology relevant to human bone marrow lesions and pain (2024)
Journal Article
McWilliams, D. F., Shahtaheri, M., Koushesh, S., Joseph, C., Gowler, P. R., Xu, L., Chapman, V., Sofat, N., & Walsh, D. A. (2025). The rat osteoarthritis bone score for histological pathology relevant to human bone marrow lesions and pain. Osteoarthritis and Cartilage Open, 7(1), Article 100544. https://doi.org/10.1016/j.ocarto.2024.100544

Objectives
Histological osteochondral characteristics of inflammation, fibrosis, vascularity, cartilage islands, vessels entering cartilage, thickened trabeculae and cysts are associated with bone marrow lesions (BMLs) in human knee osteoarthritis (... Read More about The rat osteoarthritis bone score for histological pathology relevant to human bone marrow lesions and pain.

The rat Osteoarthritis Bone Score: a new histological system for scoring subchondral pathology in rat knees analogous to histological correlates of human OA bone marrow lesions (2024)
Presentation / Conference Contribution
McWilliams, D. F., Shahtaheri, M., Koushesh, S., Joseph, C., Gowler, P., Chapman, V., Sofat, N., & Walsh, D. A. The rat Osteoarthritis Bone Score: a new histological system for scoring subchondral pathology in rat knees analogous to histological correlates of human OA bone marrow lesions. Presented at 2024 OARSI World Congress on Osteoarthritis, Vienna, Austria

Purpose (the aim of the study): Bone marrow lesions (BMLs) are detected by MRI in the in human osteoarthritis (OA) subchondral bone and associated with pain. We previously described 7 histological features associated with BMLs from which we developed... Read More about The rat Osteoarthritis Bone Score: a new histological system for scoring subchondral pathology in rat knees analogous to histological correlates of human OA bone marrow lesions.