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All Outputs (15)

Disassembly of self-assembling peptide hydrogels as a versatile method for cell extraction and manipulation (2024)
Journal Article
Ligorio, C., Martinez-Espuga, M., Laurenza, D., Hartley, A., Rodgers, C. B., Kotowska, A. M., Scurr, D. J., Dalby, M. J., Ordóñez-Morán, P., & Mata, A. (2024). Disassembly of self-assembling peptide hydrogels as a versatile method for cell extraction and manipulation. Journal of Materials Chemistry B, 12(46), 11939-11952. https://doi.org/10.1039/D4TB01575D

Self-assembling peptide hydrogels (SAPHs) are increasingly being used as two-dimensional (2D) cell culture substrates and three-dimensional (3D) matrices due to their tunable properties and biomimicry of native tissues. Despite these advantages, SAPH... Read More about Disassembly of self-assembling peptide hydrogels as a versatile method for cell extraction and manipulation.

084 Cosmetic peptide penetration and assembly in human skin: A label-free approach (2024)
Presentation / Conference Contribution
Ligorio, C., Kotowska, A., Scurr, D., Tavasoli, E., Karaman-Jurukovska, N., Mata, A., Moogan, L., German, G., Lu, F., & Mammone, T. (2024, May). 084 Cosmetic peptide penetration and assembly in human skin: A label-free approach. Presented at Society for Investigative Dermatology (SID) 2024 Meeting, Dallas, TX

Collagen-like Osteoclast-Associated Receptor (OSCAR)-Binding Motifs Show a Co-Stimulatory Effect on Osteoclastogenesis in a Peptide Hydrogel System (2023)
Journal Article
Vitale, M., Ligorio, C., Richardson, S. M., Hoyland, J. A., & Bella, J. (2023). Collagen-like Osteoclast-Associated Receptor (OSCAR)-Binding Motifs Show a Co-Stimulatory Effect on Osteoclastogenesis in a Peptide Hydrogel System. International Journal of Molecular Sciences, 25(1), Article 445. https://doi.org/10.3390/ijms25010445

Osteoclastogenesis, one of the dynamic pathways underlying bone remodelling, is a complex process that includes many stages. This complexity, while offering a wealth of therapeutic opportunities, represents a substantial challenge in unravelling the... Read More about Collagen-like Osteoclast-Associated Receptor (OSCAR)-Binding Motifs Show a Co-Stimulatory Effect on Osteoclastogenesis in a Peptide Hydrogel System.

Co-assembling living material as an in vitro lung epithelial infection model (2023)
Journal Article
Wu, Y., Romero, M., Robertson, S. N., Fenn, S., Fisher, L., Willingham, I., Martinez Pomares, L., Ligorio, C., Hill, J., Bu, W., Zhou, Z., Wildman, R. D., Ghaemmaghami, A. M., Sun, H., Sun, J., Cámara, M., & Mata, A. (2024). Co-assembling living material as an in vitro lung epithelial infection model. Matter, 7(1), 216-236. https://doi.org/10.1016/j.matt.2023.10.029

Biofilms are robust living 3D materials that play key roles in nature but also cause major problems, such as tolerance to antibiotic treatment. Recreation of these living structures in vitro is critical to understand their biology and develop solutio... Read More about Co-assembling living material as an in vitro lung epithelial infection model.

Nanocrystalline Cellulose as a Versatile Engineering Material for Extrusion-Based Bioprinting (2023)
Journal Article
A. Read, S., Shuen Go, C., J. S. Ferreira, M., Ligorio, C., Kimber, S., G. Dumanli, A., & Domingos, M. (2023). Nanocrystalline Cellulose as a Versatile Engineering Material for Extrusion-Based Bioprinting. Pharmaceutics, 15(10), Article 2432. https://doi.org/10.3390/pharmaceutics15102432

Naturally derived polysaccharide-based hydrogels, such as alginate, are frequently used in the design of bioinks for 3D bioprinting. Traditionally, the formulation of such bioinks requires the use of pre-reticulated materials with low viscosities, wh... Read More about Nanocrystalline Cellulose as a Versatile Engineering Material for Extrusion-Based Bioprinting.

Synthetic extracellular matrices with function-encoding peptides (2023)
Journal Article
Ligorio, C., & Mata, A. (2023). Synthetic extracellular matrices with function-encoding peptides. Nature Reviews Bioengineering, 1, 518–536. https://doi.org/10.1038/s44222-023-00055-3

The communication of cells with their surroundings is mostly encoded in the epitopes of structural and signalling proteins present in the extracellular matrix (ECM). These peptide epitopes can be incorporated in biomaterials to serve as function-enco... Read More about Synthetic extracellular matrices with function-encoding peptides.

Incorporation of Natural and Recombinant Collagen Proteins within Fmoc-Based Self-Assembling Peptide Hydrogels (2022)
Journal Article
Vitale, M., Ligorio, C., Smith, I. P., Richardson, S. M., Hoyland, J. A., & Bella, J. (2022). Incorporation of Natural and Recombinant Collagen Proteins within Fmoc-Based Self-Assembling Peptide Hydrogels. Gels, 8(5), 254. https://doi.org/10.3390/gels8050254

Hydrogel biomaterials mimic the natural extracellular matrix through their nanofibrous ultrastructure and composition and provide an appropriate environment for cell–matrix and cell–cell interactions within their polymeric network. Hydrogels can be m... Read More about Incorporation of Natural and Recombinant Collagen Proteins within Fmoc-Based Self-Assembling Peptide Hydrogels.

Self-Assembling Peptide Hydrogels as Functional Tools to Tackle Intervertebral Disc Degeneration (2022)
Journal Article
Ligorio, C., Hoyland, J., Hoyland, J. A., & Saiani, A. (2022). Self-Assembling Peptide Hydrogels as Functional Tools to Tackle Intervertebral Disc Degeneration. Gels, 8(4), 211. https://doi.org/10.3390/gels8040211

Low back pain (LBP), caused by intervertebral disc (IVD) degeneration, is a major contributor to global disability. In its healthy state, the IVD is a tough and well-hydrated tissue, able to act as a shock absorber along the spine. During degeneratio... Read More about Self-Assembling Peptide Hydrogels as Functional Tools to Tackle Intervertebral Disc Degeneration.

Acidic and basic self-assembling peptide and peptide-graphene oxide hydrogels: characterisation and effect on encapsulated nucleus pulposus cells (2022)
Journal Article
Ligorio, C., Vijayaraghavan, A., Hoyland, J. A., & Saiani, A. (2022). Acidic and basic self-assembling peptide and peptide-graphene oxide hydrogels: characterisation and effect on encapsulated nucleus pulposus cells. Acta Biomaterialia, 143, 145-158. https://doi.org/10.1016/j.actbio.2022.02.022

Extracellular pH can have a profound effect on cell metabolism, gene and protein expression. Nucleus pulposus (NP) cells, for example, under acidic conditions accelerate the production of degradative enzymes and pro-inflammatory cytokines, leading ul... Read More about Acidic and basic self-assembling peptide and peptide-graphene oxide hydrogels: characterisation and effect on encapsulated nucleus pulposus cells.

TGF-β3-loaded graphene oxide - self-assembling peptide hybrid hydrogels as functional 3D scaffolds for the regeneration of the nucleus pulposus (2021)
Journal Article
Ligorio, C., O'Brien, M., Hodson, N. W., Mironov, A., Iliut, M., Miller, A. F., Vijayaraghavan, A., Hoyland, J. A., & Saiani, A. (2021). TGF-β3-loaded graphene oxide - self-assembling peptide hybrid hydrogels as functional 3D scaffolds for the regeneration of the nucleus pulposus. Acta Biomaterialia, 127, 116-130. https://doi.org/10.1016/j.actbio.2021.03.077

Intervertebral disc (IVD) degeneration is a process that starts in the central nucleus pulposus (NP) and leads to inflammation, extracellular matrix (ECM) degradation, and progressive loss of disc height. Early treatment of IVD degeneration is critic... Read More about TGF-β3-loaded graphene oxide - self-assembling peptide hybrid hydrogels as functional 3D scaffolds for the regeneration of the nucleus pulposus.

Engineering a cell-hydrogel-fibre composite to mimic the structure and function of the tendon synovial sheath (2020)
Journal Article
Imere, A., Ligorio, C., O'Brien, M., Wong, J. K., Domingos, M., & Cartmell, S. H. (2020). Engineering a cell-hydrogel-fibre composite to mimic the structure and function of the tendon synovial sheath. Acta Biomaterialia, 119(1), 140-154. https://doi.org/10.1016/j.actbio.2020.11.017

The repair of tendon injuries is often compromised by post-operative peritendinous adhesions. Placing a physical barrier at the interface between the tendon and the surrounding tissue could potentially solve this problem by reducing adhesion formatio... Read More about Engineering a cell-hydrogel-fibre composite to mimic the structure and function of the tendon synovial sheath.

Methylcellulose Hydrogel with Melissa officinalis Essential Oil as a Potential Treatment for Oral Candidiasis (2020)
Journal Article
Serra, E., Saubade, F., Ligorio, C., Whitehead, K., Sloan, A., W. Williams, D., Hidalgo-Bastida, A., Verran, J., & Malic, S. (2020). Methylcellulose Hydrogel with Melissa officinalis Essential Oil as a Potential Treatment for Oral Candidiasis. Microorganisms, 8(2), Article 215. https://doi.org/10.3390/microorganisms8020215

Candida spp. are the most prevalent fungi of the human microbiota and are opportunistic pathogens that can cause oral candidiasis. Management of such infections is limited due to the low number of antifungal drugs available, their relatively high tox... Read More about Methylcellulose Hydrogel with Melissa officinalis Essential Oil as a Potential Treatment for Oral Candidiasis.

Graphene oxide containing self-assembling peptide hybrid hydrogels as a potential 3D injectable cell delivery platform for intervertebral disc repair applications (2019)
Journal Article
Ligorio, C., Zhou, M., Wychowaniec, J. K., Zhu, X., Bartlam, C., Miller, A. F., Vijayaraghavan, A., Hoyland, J. A., & Saiani, A. (2019). Graphene oxide containing self-assembling peptide hybrid hydrogels as a potential 3D injectable cell delivery platform for intervertebral disc repair applications. Acta Biomaterialia, 92, 92-103. https://doi.org/10.1016/j.actbio.2019.05.004

Cell-based therapies have shown significant promise in tissue engineering with one key challenge being the delivery and retention of cells. As a result, significant efforts have been made in the past decade to design injectable biomaterials to host a... Read More about Graphene oxide containing self-assembling peptide hybrid hydrogels as a potential 3D injectable cell delivery platform for intervertebral disc repair applications.

Four-dimensional imaging and quantification of viscous flow sintering within a 3D printed bioactive glass scaffold using synchrotron X-ray tomography (2019)
Journal Article
Nommeots-Nomm, A., Ligorio, C., Bodey, A. J., Cai, B., Jones, J. R., Lee, P. D., & Poologasundarampillai, G. (2019). Four-dimensional imaging and quantification of viscous flow sintering within a 3D printed bioactive glass scaffold using synchrotron X-ray tomography. Materials Today Advances, 2, Article 100011. https://doi.org/10.1016/j.mtadv.2019.100011

Bioglass® was the first material to form a stable chemical bond with human tissue. Since its discovery, a key goal was to produce three-dimensional (3D) porous scaffolds which can host and guide tissue repair, in particular, regeneration of long bone... Read More about Four-dimensional imaging and quantification of viscous flow sintering within a 3D printed bioactive glass scaffold using synchrotron X-ray tomography.