All Outputs (11)

A Systematic Review of the Biological Effects of Cordycepin (2021)
Journal Article
Radhi, M., Ashraf, S., Lawrence, S., Tranholm, A. A., Wellham, P. A. D., Hafeez, A., …De Moor, C. H. (2021). A Systematic Review of the Biological Effects of Cordycepin. Molecules, 26(19), Article 5886. https://doi.org/10.3390/molecules26195886

We conducted a systematic review of the literature on the effects of cordycepin on cell survival and proliferation, inflammation, signal transduction and animal models. A total of 1204 publications on cordycepin were found by the cut-off date of 1 Fe... Read More about A Systematic Review of the Biological Effects of Cordycepin.

Culture degeneration reduces sex-related gene expression, alters metabolite production and reduces insect pathogenic response in cordyceps militaris (2021)
Journal Article
Wellham, P. A. D., Hafeez, A., Gregori, A., Brock, M., Kim, D. H., Chandler, D., & de Moor, C. H. (2021). Culture degeneration reduces sex-related gene expression, alters metabolite production and reduces insect pathogenic response in cordyceps militaris. Microorganisms, 9(8), Article 1559. https://doi.org/10.3390/microorganisms9081559

Cordyceps militaris is an entomopathogenic ascomycete, known primarily for infecting lepidopteran larval (caterpillars) and pupal hosts. Cordycepin, a secondary metabolite produced by this fungus has anti-inflammatory properties and other pharmacolog... Read More about Culture degeneration reduces sex-related gene expression, alters metabolite production and reduces insect pathogenic response in cordyceps militaris.

Cordycepin, a metabolite of Cordyceps militaris, reduces immune-related gene expression in insects (2020)
Journal Article
Woolley, V. C., Teakle, G. R., Prince, G., de Moor, C. H., & Chandler, D. (2020). Cordycepin, a metabolite of Cordyceps militaris, reduces immune-related gene expression in insects. Journal of Invertebrate Pathology, 177, Article 107480. https://doi.org/10.1016/j.jip.2020.107480

Hypocrealean entomopathogenic fungi (EPF) (Sordariomycetes, Ascomycota) are natural regulators of insect populations in terrestrial environments. Their obligately-killing life-cycle means that there is likely to be strong selection pressure for trait... Read More about Cordycepin, a metabolite of Cordyceps militaris, reduces immune-related gene expression in insects.

DEAD-box helicase eIF4A2 inhibits CNOT7 deadenylation activity (2019)
Journal Article
Meijer, H. A., Schmidt, T., Gillen, S. L., Langlais, C., Jukes-Jones, R., de Moor, C. H., …Bushell, M. (2019). DEAD-box helicase eIF4A2 inhibits CNOT7 deadenylation activity. Nucleic Acids Research, 47(15), 8224-8238. https://doi.org/10.1093/nar/gkz509

The CCR4–NOT complex plays an important role in the translational repression and deadenylation of mRNAs. However, little is known about the specific roles of interacting factors. We demonstrate that the DEAD-box helicases eIF4A2 and DDX6 interact dir... Read More about DEAD-box helicase eIF4A2 inhibits CNOT7 deadenylation activity.

Lung function associated gene Integrator Complex subunit 12 regulates protein synthesis pathways (2017)
Journal Article
Kheirallah, A. K., de Moor, C. H., Faiz, A., Sayers, I., & Hall, I. P. (2017). Lung function associated gene Integrator Complex subunit 12 regulates protein synthesis pathways. BMC Genomics, 18(1), Article 248. https://doi.org/10.1186/s12864-017-3628-3

BACKGROUND: Genetic studies of human lung function and Chronic Obstructive Pulmonary Disease have identified a highly significant and reproducible signal on 4q24. It remains unclear which of the two candidate genes within this locus may regulate lung... Read More about Lung function associated gene Integrator Complex subunit 12 regulates protein synthesis pathways.

Hyperlipidaemia alone and in combination with acidosis can increase the incidence and severity of statin-induced myotoxicity (2017)
Journal Article
Taha, D. A., Zgair, A., Lee, J. B., de Moor, C. H., Barrett, D. A., Bruce, K. D., …Gershkovich, P. (2017). Hyperlipidaemia alone and in combination with acidosis can increase the incidence and severity of statin-induced myotoxicity. European Journal of Pharmaceutical Sciences, 100, 163-175. https://doi.org/10.1016/j.ejps.2017.01.018

The association of lipophilic statins with plasma lipoproteins in the presence of disturbed acid-base balance can modify the pharmacokinetics and tissue distribution of these drugs, resulting in alteration in their efficacy and toxicity profiles. The... Read More about Hyperlipidaemia alone and in combination with acidosis can increase the incidence and severity of statin-induced myotoxicity.

The role of acid-base imbalance in statin-induced myotoxicity (2016)
Journal Article
Taha, D. A., de Moor, C. H., Barrett, D. A., Lee, J. B., Gandhi, R. D., Hoo, C. W., & Gershkovich, P. (2016). The role of acid-base imbalance in statin-induced myotoxicity. Translational Research, The Journal of Laboratory and Clinical Medicine, 174, 140-160.e14. https://doi.org/10.1016/j.trsl.2016.03.015

Disturbances in acid-base balance, such as acidosis and alkalosis, have potential to alter the pharmacological and toxicological outcomes of statin therapy. Statins are commonly prescribed for elderly patients who have multiple co-morbidities such as... Read More about The role of acid-base imbalance in statin-induced myotoxicity.

Genome-wide analysis of PAPS1-dependent polyadenylation identifies novel roles for functionally specialized poly(A) polymerases in Arabidopsis thaliana (2015)
Journal Article
Kappel, C., Trost, G., Cseznick, H., Ramming, A., Kolbe, B., Vi, S. L., …Lenhard, M. (2015). Genome-wide analysis of PAPS1-dependent polyadenylation identifies novel roles for functionally specialized poly(A) polymerases in Arabidopsis thaliana. PLoS Genetics, 11(8), Article e1005474. https://doi.org/10.1371/journal.pgen.1005474

The poly(A) tail at 3’ ends of eukaryotic mRNAs promotes their nuclear export, stability and translational efficiency, and changes in its length can strongly impact gene expression. The Arabidopsis thaliana genome encodes three canonical nuclear poly... Read More about Genome-wide analysis of PAPS1-dependent polyadenylation identifies novel roles for functionally specialized poly(A) polymerases in Arabidopsis thaliana.

GSM1386775: Ler - sample 1 - long fraction (2015)
Data
Michael, L., Cornelia, D. M., Christian, K., Gerda, T., H, C., Anna, R., …JD, B. (2015). GSM1386775: Ler - sample 1 - long fraction. [Dataset]

The poly(A) tail at 3' ends of eukaryotic mRNAs promotes their nuclear export, stability and translational efficiency, and changes in its length can strongly impact gene expression. The Arabidopsis thaliana genome encodes three canonical nuclear poly... Read More about GSM1386775: Ler - sample 1 - long fraction.

GSM1386776: Ler - sample 1 -short fraction (2015)
Data
Cornelia, D. M., Michael, L., Christian, K., Gerda, T., H, C., Anna, R., …JD, B. (2015). GSM1386776: Ler - sample 1 -short fraction. [Dataset]

The poly(A) tail at 3' ends of eukaryotic mRNAs promotes their nuclear export, stability and translational efficiency, and changes in its length can strongly impact gene expression. The Arabidopsis thaliana genome encodes three canonical nuclear poly... Read More about GSM1386776: Ler - sample 1 -short fraction.

Specificity factors in cytoplasmic polyadenylation (2013)
Journal Article
Charlesworth, A., Meijer, H. A., & de Moor, C. H. (2013). Specificity factors in cytoplasmic polyadenylation. Wiley Interdisciplinary Reviews: RNA, 4(4), https://doi.org/10.1002/wrna.1171

Poly(A) tail elongation after export of an messenger RNA (mRNA) to the cytoplasm is called cytoplasmic polyadenylation. It was first discovered in oocytes and embryos, where it has roles in meiosis and development. In recent years, however, has been... Read More about Specificity factors in cytoplasmic polyadenylation.