PAR2 on oral cancer cells and nociceptors contributes to oral cancer pain that can be relieved by nanoparticle-encapsulated AZ3451

Bhansali, Divya; Tu, Nguyen H.; Inoue, Kenji; Teng, Shavonne; Li, Tianyu; Tran, Hung D.; Kim, Dong H.; Dong, Jessy; Peach, Chloe J.; Sokrat, Badr; Jensen, Dane D.; Dolan, John C.; Yamano, Seiichi; Robinson, Valeria Mezzano; Bunnett, Nigel W.; Albertson, Donna G.; Leong, Kam W.; Schmidt, Brian L.

doi:10.1016/j.biomaterials.2024.122874

All Outputs (3)

Myosin VI drives arrestin-independent internalization and signaling of GPCRs (2024)
Journal Article
Patel, N. M., Ripoll, L., Peach, C. J., Ma, N., Blythe, E. E., Vaidehi, N., Bunnett, N. W., von Zastrow, M., & Sivaramakrishnan, S. (2024). Myosin VI drives arrestin-independent internalization and signaling of GPCRs. Nature Communications, 15, Article 10636. https://doi.org/10.1038/s41467-024-55053-9

G protein-coupled receptor (GPCR) endocytosis is canonically associated with β-arrestins. Here, we delineate a β-arrestin-independent endocytic pathway driven by the cytoskeletal motor, myosin VI. Myosin VI engages GIPC, an adaptor protein that binds... Read More about Myosin VI drives arrestin-independent internalization and signaling of GPCRs.

Neuropilin-1 inhibition suppresses nerve growth factor signaling and nociception in pain models (2024)
Journal Article
Peach, C. J., Tonello, R., Damo, E., Gomez, K., Calderon-Rivera, A., Bruni, R., Bansia, H., Maile, L., Manu, A. M., Hahn, H., Thomsen, A. R., Schmidt, B. L., Davidson, S., des Georges, A., Khanna, R., & Bunnett, N. W. (2025). Neuropilin-1 inhibition suppresses nerve growth factor signaling and nociception in pain models. Journal of Clinical Investigation, 135(4), Article e183873. https://doi.org/10.1172/JCI183873

Nerve growth factor (NGF) monoclonal antibodies inhibit chronic pain, yet failed to gain approval due to worsened joint damage in osteoarthritis patients. We report that neuropilin-1 (NRP1) is a coreceptor for NGF and tropomyosin-related kinase A (Tr... Read More about Neuropilin-1 inhibition suppresses nerve growth factor signaling and nociception in pain models.

PAR2 on oral cancer cells and nociceptors contributes to oral cancer pain that can be relieved by nanoparticle-encapsulated AZ3451 (2024)
Journal Article
Bhansali, D., Tu, N. H., Inoue, K., Teng, S., Li, T., Tran, H. D., Kim, D. H., Dong, J., Peach, C. J., Sokrat, B., Jensen, D. D., Dolan, J. C., Yamano, S., Robinson, V. M., Bunnett, N. W., Albertson, D. G., Leong, K. W., & Schmidt, B. L. (2025). PAR2 on oral cancer cells and nociceptors contributes to oral cancer pain that can be relieved by nanoparticle-encapsulated AZ3451. Biomaterials, 314, Article 122874. https://doi.org/10.1016/j.biomaterials.2024.122874

Oral cancer is notoriously painful. Activation of protease-activated receptor 2 (PAR2, encoded by F2RL1) by proteases in the cancer microenvironment is implicated in oral cancer pain. PAR2 is a G protein-coupled receptor (GPCR) expressed on neurons a... Read More about PAR2 on oral cancer cells and nociceptors contributes to oral cancer pain that can be relieved by nanoparticle-encapsulated AZ3451.