All Outputs (98)

Sickle Cell Disorders and Severe COVID-19 Outcomes: A Cohort Study (2021)
Journal Article
Clift, A. K., Saatci, D., Coupland, C. A., Dambha-Miller, H., Hippisley-Cox, J., & International Investigator Group for Ethnicity and COVID-19. (2021). Sickle Cell Disorders and Severe COVID-19 Outcomes: A Cohort Study. Annals of Internal Medicine, 174(10), 1483-1487. https://doi.org/10.7326/M21-1375

Background: Sickle cell disease is a collection of compound heterozygote hemoglobinopathies, including sickle cell anemia (1). The heterozygote hemoglobinopathies are characterized by erythrocyte deformation with hemolysis; immune and coagulation dys... Read More about Sickle Cell Disorders and Severe COVID-19 Outcomes: A Cohort Study.

Implementation fidelity of the Falls Management Exercise Programme: a mixed methods analysis using a conceptual framework for implementation fidelity (2021)
Journal Article
Orton, E., Lafond, N., Skelton, D. A., Coupland, C., Gladman, J. R., Iliffe, S., …Kendrick, D. (2021). Implementation fidelity of the Falls Management Exercise Programme: a mixed methods analysis using a conceptual framework for implementation fidelity. Public Health, 197, 11-18. https://doi.org/10.1016/j.puhe.2021.05.038

Objectives: Falls in older adults cause significant morbidity and mortality and incur cost to health and care services. The Falls Management Exercise (FaME) programme is a 24-week intervention for older adults that, in clinical trials, improves balan... Read More about Implementation fidelity of the Falls Management Exercise Programme: a mixed methods analysis using a conceptual framework for implementation fidelity.

An external validation of the QCovid risk prediction algorithm for risk of mortality from COVID-19 in adults: a national validation cohort study in England (2021)
Journal Article
Nafilyan, V., Humberstone, B., Mehta, N., Diamond, I., Coupland, C., Lorenzi, L., …Hippisley-Cox, J. (2021). An external validation of the QCovid risk prediction algorithm for risk of mortality from COVID-19 in adults: a national validation cohort study in England. The Lancet. Digital Health, 3(7), E425-E433. https://doi.org/10.1016/S2589-7500%2821%2900080-7

Background: Public policy measures and clinical risk assessments relevant to COVID-19 need to be aided by risk prediction models that are rigorously developed and validated. We aimed to externally validate a risk prediction algorithm (QCovid) to esti... Read More about An external validation of the QCovid risk prediction algorithm for risk of mortality from COVID-19 in adults: a national validation cohort study in England.

Mortality and critical care unit admission associated with the SARS-CoV-2 lineage B.1.1.7 in England: an observational cohort study (2021)
Journal Article
Patone, M., Thomas, K., Hatch, R., Tan, P. S., Coupland, C., Liao, W., …Hippisley-Cox, J. (2021). Mortality and critical care unit admission associated with the SARS-CoV-2 lineage B.1.1.7 in England: an observational cohort study. Lancet Infectious Diseases, 21(11), 1518-1528. https://doi.org/10.1016/s1473-3099%2821%2900318-2

Background: A more transmissible variant of SARS-CoV-2, the variant of concern 202012/01 or lineage B.1.1.7, has emerged in the UK. We aimed to estimate the risk of critical care admission, mortality in patients who are critically ill, and overall mo... Read More about Mortality and critical care unit admission associated with the SARS-CoV-2 lineage B.1.1.7 in England: an observational cohort study.

Impact of the national home safety equipment scheme ‘Safe At Home’ on hospital admissions for unintentional injury in children under 5: controlled interrupted time series analysis (2021)
Journal Article
Hill, T., Coupland, C., Kendrick, D., Jones, M., Akbari, A., Rodgers, S., …Orton, E. (2022). Impact of the national home safety equipment scheme ‘Safe At Home’ on hospital admissions for unintentional injury in children under 5: controlled interrupted time series analysis. Journal of Epidemiology and Community Health, 76(1), 53-59. https://doi.org/10.1136/jech-2021-216613

Background: Unintentional home injuries are a leading cause of preventable death in young children. Safety education and equipment provision improve home safety practices, but their impact on injuries is less clear. Between 2009 and 2011 a national h... Read More about Impact of the national home safety equipment scheme ‘Safe At Home’ on hospital admissions for unintentional injury in children under 5: controlled interrupted time series analysis.

Association Between Race and COVID-19 Outcomes Among 2.6 Million Children in England (2021)
Journal Article
Saatci, D., Ranger, T. A., Garriga, C., Clift, A. K., Zaccardi, F., Tan, P. S., …Hippisley-Cox, J. (2021). Association Between Race and COVID-19 Outcomes Among 2.6 Million Children in England. JAMA Pediatrics, 175(9), 928-938. https://doi.org/10.1001/jamapediatrics.2021.1685

Importance: Although children mainly experience mild COVID-19 disease, hospitalization rates are increasing, with limited understanding of underlying factors. There is an established association between race and severe COVID-19 outcomes in adults in... Read More about Association Between Race and COVID-19 Outcomes Among 2.6 Million Children in England.

Anticholinergic drugs and risk of dementia: Time for action? (2021)
Journal Article
Bell, B., Avery, A., Bishara, D., Coupland, C., Ashcroft, D., & Orrell, M. (2021). Anticholinergic drugs and risk of dementia: Time for action?. Pharmacology Research and Perspectives, 9(3), Article e00793. https://doi.org/10.1002/prp2.793

Evidence suggests that the prescription of bladder anticholinergics is increasing. Recent studies have accentuated concerns about whether certain prescribed medications could increase risk of dementia, including anticholinergic drugs, and specificall... Read More about Anticholinergic drugs and risk of dementia: Time for action?.

Depression, anxiety and stress during the COVID-19 pandemic: results from a New Zealand cohort study on mental well-being (2021)
Journal Article
Gasteiger, N., Vedhara, K., Massey, A., Jia, R., Ayling, K., Chalder, T., …Broadbent, E. (2021). Depression, anxiety and stress during the COVID-19 pandemic: results from a New Zealand cohort study on mental well-being. BMJ Open, 11(5), Article e045325. https://doi.org/10.1136/bmjopen-2020-045325

Objectives: The COVID-19 pandemic has caused unprecedented disruption to daily life. This study investigated depression, anxiety and stress in New Zealand (NZ) during the first ten weeks of the COVID-19 pandemic, and associated psychological and beha... Read More about Depression, anxiety and stress during the COVID-19 pandemic: results from a New Zealand cohort study on mental well-being.

Predicting the risk of prostate cancer in asymptomatic men: a cohort study to develop and validate a novel algorithm (2021)
Journal Article
Coupland, C., & Hippisley-Cox, J. (2021). Predicting the risk of prostate cancer in asymptomatic men: a cohort study to develop and validate a novel algorithm. British Journal of General Practice, 71(706), e364-e371. https://doi.org/10.3399/bjgp20x714137

Background: Diagnosis of prostate cancer at an early stage can potentially identify tumours when intervention may improve treatment options and survival.

Aim: To develop and validate an equation to predict absolute risk of prostate cancer in asymp... Read More about Predicting the risk of prostate cancer in asymptomatic men: a cohort study to develop and validate a novel algorithm.

Quantifying the association between ethnicity and COVID-19 mortality: a national cohort study protocol (2021)
Journal Article
Dambha-Miller, H., San Tan, P., Saatci, D., Kieran Clift, A., Zaccardi, F., Coupland, C., …Hippisley-Cox, J. (2021). Quantifying the association between ethnicity and COVID-19 mortality: a national cohort study protocol. BMJ Open, 11(4), Article e045286. https://doi.org/10.1136/bmjopen-2020-045286

Introduction: Recent evidence suggests that ethnic minority groups are disproportionately at increased risk of hospitalisation and death from SARS-CoV-2 infection. Population-based evidence on potential explanatory factors across minority groups and... Read More about Quantifying the association between ethnicity and COVID-19 mortality: a national cohort study protocol.

Association between pre-existing respiratory disease and its treatments and severe COVID-19: population cohort study (2021)
Journal Article
Aveyard, P., Gao, M., Lindson, N., Hartmann-Boyce, J., Watkinson, P., Young, D., …Hippisley-Cox, J. (2021). Association between pre-existing respiratory disease and its treatments and severe COVID-19: population cohort study. Lancet Respiratory Medicine, 9(8), 909-923. https://doi.org/10.1016/S2213-2600%2821%2900095-3

Background: The aim was to assess whether chronic lung disease or use of inhaled corticosteroids (ICS) affect the risk of contracting severe COVID-19.

Methods: English general practice records from the QResearch database were linked to Public Hea... Read More about Association between pre-existing respiratory disease and its treatments and severe COVID-19: population cohort study.

Hormone replacement therapy in women with cancer and risk of cancer-specific mortality and cardiovascular disease: A protocol for a cohort study from Scotland and Wales (2021)
Journal Article
McMenamin, Ú., Hicks, B., Hughes, C., Murchie, P., Hippisley-Cox, J., Ranger, T., …Cardwell, C. (in press). Hormone replacement therapy in women with cancer and risk of cancer-specific mortality and cardiovascular disease: A protocol for a cohort study from Scotland and Wales. BMC Cancer, 21, Article 313. https://doi.org/10.1186/s12885-021-08065-3

Background: Hormone replacement therapy (HRT) is widely used and has proven benefits for women with menopausal symptoms. An increasing number of women with cancer experience menopausal symptoms but the safety of HRT use in women with cancer is uncl... Read More about Hormone replacement therapy in women with cancer and risk of cancer-specific mortality and cardiovascular disease: A protocol for a cohort study from Scotland and Wales.

Temporal relationship between osteoarthritis and comorbidities: a combined case control and cohort study in the UK primary care setting (2021)
Journal Article
Swain, S., Coupland, C., Mallen, C., Kuo, C. F., Sarmanova, A., Bierma-Zeinstra, S. M., …Zhang, W. (2021). Temporal relationship between osteoarthritis and comorbidities: a combined case control and cohort study in the UK primary care setting. Rheumatology, 60(9), 4327-4339. https://doi.org/10.1093/rheumatology/keab067

OBJECTIVE: To determine the burden of comorbidities in OA and their temporal relationships in the UK.

METHODS: The Clinical Practice Research Datalink (CPRD) GOLD was used to identify people with incident OA and age, gender and practice matched n... Read More about Temporal relationship between osteoarthritis and comorbidities: a combined case control and cohort study in the UK primary care setting.

Hormone replacement therapy and dementia risk: nested case-control studies using CPRD and QResearch (2021)
Journal Article
Vinogradova, Y., Dening, T., Hippisley-Cox, J., Taylor, L., Moore, M., & Coupland, C. (2021). Hormone replacement therapy and dementia risk: nested case-control studies using CPRD and QResearch. East Midlands Research into Ageing Network (EMRAN) Discussion Paper Series, 38, 1-16

Introduction: Research from clinical trials of hormone replacement therapy (HRT) has produced conflicting findings about possible risks of dementia after receiving these treatments, and further research on HRT and dementia risk has been identified as... Read More about Hormone replacement therapy and dementia risk: nested case-control studies using CPRD and QResearch.

PROTOCOL: A cohort study examining the association between mirtazapine and mortality risk in adults with a diagnosis of depression (2021)
Preprint / Working Paper
Joseph, R. M., Jack, R. H., Morriss, R., Knaggs, R. D., Hollis, C., Hippisley-Cox, J., & Coupland, C. PROTOCOL: A cohort study examining the association between mirtazapine and mortality risk in adults with a diagnosis of depression

This protocol describes a cohort study comparing the risks of mortality and serious self-harm (suicide or near-fatal deliberate self-harm) between adults with depression prescribed mirtazapine, a selective serotonin reuptake inhibitor (SSRI), amitrip... Read More about PROTOCOL: A cohort study examining the association between mirtazapine and mortality risk in adults with a diagnosis of depression.

‘Real world’ effectiveness of the Falls Management Exercise (FaME) programme: an implementation study (2021)
Journal Article
Orton, E., Audsley, S., Coupland, C., Gladman, J. R., Iliffe, S., Lafond, N., …Kendrick, D. (2021). ‘Real world’ effectiveness of the Falls Management Exercise (FaME) programme: an implementation study. Age and Ageing, 50(4), 1290-1297. https://doi.org/10.1093/ageing/afaa288

Background
Falls incidence increases with age alongside declines in strength and balance. Clinical trials show that the Falls Management Exercise (FaME) programme improves strength and balance, which can reduce falls and improve physical functioning... Read More about ‘Real world’ effectiveness of the Falls Management Exercise (FaME) programme: an implementation study.

Prostate-specific antigen testing and opportunistic prostate cancer screening: a cohort study in England, 1998–2017 (2021)
Journal Article
Clift, A. K., Coupland, C. A., & Hippisley-Cox, J. (2021). Prostate-specific antigen testing and opportunistic prostate cancer screening: a cohort study in England, 1998–2017. British Journal of General Practice, 71(703), e157-e165. https://doi.org/10.3399/bjgp20X713957

Background: Prostate cancer is a leading cause of cancer-related death. Interpretation of results from trials of screening with prostate-specific antigen (PSA) are complex in terms of defining optimal prostate cancer screening policy.

Aims: Assess... Read More about Prostate-specific antigen testing and opportunistic prostate cancer screening: a cohort study in England, 1998–2017.

Development and validation of a novel algorithm to estimate risk of developing prostate cancer in asymptomatic men: a cohort study (2020)
Journal Article
Hippisley-Cox, J., & Coupland, C. (2021). Development and validation of a novel algorithm to estimate risk of developing prostate cancer in asymptomatic men: a cohort study. British Journal of General Practice, 71(706), E364-E371. https://doi.org/10.3399/bjgp20X714137

Abstract Objective: To develop and validate a risk prediction equation to predict absolute risk of prostate cancer in asymptomatic men with prostate specific antigen (PSA) tests in primary care. Design: Open cohort study. Setting: Routine data from 1... Read More about Development and validation of a novel algorithm to estimate risk of developing prostate cancer in asymptomatic men: a cohort study.

Use of hormone replacement therapy and risk of breast cancer: nested case-control studies using the QResearch and CPRD databases (2020)
Journal Article
Vinogradova, Y., Coupland, C., & Hippisley-Cox, J. (2020). Use of hormone replacement therapy and risk of breast cancer: nested case-control studies using the QResearch and CPRD databases. BMJ, 371, Article m3873. https://doi.org/10.1136/bmj.m3873

Objective: To assess breast cancer risks associated with different types and durations of hormone replacement therapy

Design: Two nested case-control studies

Setting: UK general practices contributing to QResearch or Clinical Practice Research... Read More about Use of hormone replacement therapy and risk of breast cancer: nested case-control studies using the QResearch and CPRD databases.

Living risk prediction algorithm (QCOVID) for risk of hospital admission and mortality from coronavirus 19 in adults: national derivation and validation cohort study (2020)
Journal Article
Clift, A. K., Coupland, C. A., Keogh, R. H., Diaz-Ordaz, K., Williamson, E., Harrison, E. M., …Hippisley-Cox, J. (2020). Living risk prediction algorithm (QCOVID) for risk of hospital admission and mortality from coronavirus 19 in adults: national derivation and validation cohort study. BMJ, 371, Article m3731. https://doi.org/10.1136/bmj.m3731

Objective: To derive and validate a risk prediction algorithm to estimate hospital admission and mortality outcomes from coronavirus disease 2019 (covid-19) in adults.

Design: Population based cohort study.

Setting and participants: QResearch d... Read More about Living risk prediction algorithm (QCOVID) for risk of hospital admission and mortality from coronavirus 19 in adults: national derivation and validation cohort study.