All Outputs (84)

Bacteria clustering by polymers induces the expression of quorum sense controlled phenotypes (2013)
Journal Article
Lui, L. T., Xue, X., Sui, C., Brown, A., Pritchard, D. I., Halliday, N., …Alexander, C. (2013). Bacteria clustering by polymers induces the expression of quorum sense controlled phenotypes. Nature Chemistry, 5(12), https://doi.org/10.1038/nchem.1793

Bacteria deploy a range of chemistries to regulate their behaviour and respond to their environment. Quorum sensing is one mean by which bacteria use chemical reactions to modulate pre-infection behaviour such as surface attachment. Polymers that can... Read More about Bacteria clustering by polymers induces the expression of quorum sense controlled phenotypes.

Enhanced uptake of nanoparticle drug carriers via a thermoresponsive shell enhances cytotoxicity in a cancer cell line (2013)
Journal Article
Abulateefeh, S. R., Spain, S. G., Thurecht, K. J., Aylott, J. W., Chan, W. C., Garnett, M. C., & Alexander, C. (2013). Enhanced uptake of nanoparticle drug carriers via a thermoresponsive shell enhances cytotoxicity in a cancer cell line. Biomaterials Science, 1(4), 434-442. https://doi.org/10.1039/c2bm00184e

Polymer particles consisting of a biodegradable poly[lactide-co-glycolide] (PLGA) core and a thermoresponsive shell have been formulated to encapsulate the dye rhodamine 6G and the potent cytotoxic drug paclitaxel. Cellular uptake of these particles... Read More about Enhanced uptake of nanoparticle drug carriers via a thermoresponsive shell enhances cytotoxicity in a cancer cell line.

Thermoresponsive polymer colloids for drug delivery and cancer therapy (2011)
Journal Article
Abulateefeh, S. R., Spain, S. G., Aylott, J. W., Chan, W. C., Garnett, M. C., & Alexander, C. (2011). Thermoresponsive polymer colloids for drug delivery and cancer therapy. Macromolecular Bioscience, 11(12), 1722-1734. https://doi.org/10.1002/mabi.201100252

Many difficulties in treating cancer arise from the problems in directing highly cytotoxic agents to the deseased tissues, cells and intracellular compartments. Many drug delivery systems have been devised to address this problem, including those tha... Read More about Thermoresponsive polymer colloids for drug delivery and cancer therapy.

Facile synthesis of responsive nanoparticles with reversible, tunable and rapid thermal transitions from biocompatible constituents (2009)
Journal Article
Abulateefeh, S. R., Saeed, A. O., Aylott, J. W., Chan, W. C., Garnett, M. C., Saunders, B. R., & Alexander, C. (2009). Facile synthesis of responsive nanoparticles with reversible, tunable and rapid thermal transitions from biocompatible constituents. Chemical Communications, 6068-6070. https://doi.org/10.1039/b911986h

Responsive polymeric nanoparticles composed of hybrid block co-polymers were prepared from biocompatible components that displayed rapid, tunable and multiply reversible transitions in response to change of temperature. © 2009 The Royal Society of Ch... Read More about Facile synthesis of responsive nanoparticles with reversible, tunable and rapid thermal transitions from biocompatible constituents.