All Outputs (5)

Alkyl-modified oligonucleotides as intercalating vehicles for doxorubicin uptake via albumin binding (2017)
Journal Article
Purdie, L., Alexander, C., Spain, S. G., & Magnusson, J. P. (2018). Alkyl-modified oligonucleotides as intercalating vehicles for doxorubicin uptake via albumin binding. Molecular Pharmaceutics, 15(2), https://doi.org/10.1021/acs.molpharmaceut.7b00805

DNA-based drug delivery vehicles have displayed promise for the delivery of intercalating drugs. Here, we demonstrate that oligonucleotides modified with an alkyl chain can bind to human serum albumin, mimicking the natural binding of fatty acids. Th... Read More about Alkyl-modified oligonucleotides as intercalating vehicles for doxorubicin uptake via albumin binding.

A design of experiments (DoE) approach to identify the influencing parameters that determine poly-D,L-lactic acid (PDLLA) electrospun scaffold morphologies (2017)
Journal Article
Ruiter, F. A. A., Alexander, C., Rose, F. R., & Segal, J. (2017). A design of experiments (DoE) approach to identify the influencing parameters that determine poly-D,L-lactic acid (PDLLA) electrospun scaffold morphologies. Biomedical Materials, 12(5), Article 055009. https://doi.org/10.1088/1748-605X/aa7b54

Electrospun fibrous materials have increasing applications in regenerative medicine due to the similarity of fibre constructs to the morphology of certain extracellular matrices. Although experimentally the electrospinning method is relatively simple... Read More about A design of experiments (DoE) approach to identify the influencing parameters that determine poly-D,L-lactic acid (PDLLA) electrospun scaffold morphologies.

Rapid nano-gram scale screening method of micro-arrays to evaluate drug-polymer blends using high-throughput printing technology (2017)
Journal Article
Taresco, V., Louzao, I., Scurr, D. J., Turpin, E. R., Laughton, C. A., Alexander, C., …Garnett, M. (in press). Rapid nano-gram scale screening method of micro-arrays to evaluate drug-polymer blends using high-throughput printing technology. Molecular Pharmaceutics, 14(6), https://doi.org/10.1021/acs.molpharmaceut.7b00182

A miniaturized, high-throughput assay was optimized to screen polymer-drug solid dispersions using a 2-D Ink-jet printer. By simply printing nanoliter amounts of polymer and drug solutions onto an inert surface, drug:polymer micro-dots of tunable com... Read More about Rapid nano-gram scale screening method of micro-arrays to evaluate drug-polymer blends using high-throughput printing technology.

Dually sensitive dextran-based micelles for methotrexate delivery (2017)
Journal Article
Blanco-Fernandez, B., Concheiro, A., Makwana, H., Fernandez-Trillo, F., Alexander, C., & Alvarez-Lorenzo, C. (2017). Dually sensitive dextran-based micelles for methotrexate delivery. RSC Advances, 7(24), https://doi.org/10.1039/c7ra00696a

Temperature-sensitive polymeric micelles were prepared from dextran grafted with poly(N-isopropylacrylamide) (PNIPAAm) or polyethylene glycol methyl ether (PEGMA) via controlled radical polymerization and evaluated as delivery systems of the anticanc... Read More about Dually sensitive dextran-based micelles for methotrexate delivery.

Bioreducible cross-linked core polymer micelles enhance in vitro activity of methotrexate in breast cancer cells (2017)
Journal Article
Gulfam, M., Matini, T., Monteiro, P. F., Riva, R., Collins, H., Spriggs, K., …Alexander, C. (2017). Bioreducible cross-linked core polymer micelles enhance in vitro activity of methotrexate in breast cancer cells. Biomaterials Science, 5, https://doi.org/10.1039/c6bm00888g

Polymer micelles have emerged as promising carriers for controlled release applications, however, several limitations of micelle-based drug delivery have also been reported. To address these issues, we have synthesized a functional biodegradable and... Read More about Bioreducible cross-linked core polymer micelles enhance in vitro activity of methotrexate in breast cancer cells.