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Structure-optimized interpolymer polyphosphazene complexes for effective gene delivery against glioblastoma (2018)
Journal Article
Hsu, W.-H., Sánchez-Gómez, P., Gomez-Ibarlucea, E., Ivanov, D. P., Rahman, R., Grabowska, A. M., …Garcia-Fuentes, M. (2019). Structure-optimized interpolymer polyphosphazene complexes for effective gene delivery against glioblastoma. Advanced Therapeutics, 2(3), Article 1800126. https://doi.org/10.1002/adtp.201800126

Safe and efficient gene delivery vectors will enhance the prospects for polynucleotide-based therapies. Herein a new approach toward structurally optimized gene vector design based on the preparation of clickable poly(allylamino-phosphazene)s that ca... Read More about Structure-optimized interpolymer polyphosphazene complexes for effective gene delivery against glioblastoma.

Rapid formulation of redox-responsive oligo-β-aminoester polyplexes with siRNA via jet printing (2018)
Journal Article
Lovato, T., Taresco, V., Alazzo, A., Sansone, C., Stolnik, S., Alexander, C., & Conte, C. (2018). Rapid formulation of redox-responsive oligo-β-aminoester polyplexes with siRNA via jet printing. Journal of Materials Chemistry B, 6(41), 6550-6558. https://doi.org/10.1039/C8TB01215F

Here we describe a rapid inkjet formulation method for screening newly-synthesised cationic materials for siRNA delivery into cancer cells. Reduction responsive oligo-β-aminoesters were prepared and evaluated for their ability to condense siRNA into... Read More about Rapid formulation of redox-responsive oligo-β-aminoester polyplexes with siRNA via jet printing.

In Silico Screening for Solid Dispersions: The Trouble with Solubility Parameters and χFH (2018)
Journal Article
Turpin, E. R., Taresco, V., Al-Hachami, W. A., Booth, J., Treacher, K., Tomasi, S., …Garnett, M. C. (2018). In Silico Screening for Solid Dispersions: The Trouble with Solubility Parameters and χFH. Molecular Pharmaceutics, 15(10), 4654-4667. https://doi.org/10.1021/acs.molpharmaceut.8b00637

© Copyright 2018 American Chemical Society. The problem of predicting small molecule-polymer compatibility is relevant to many areas of chemistry and pharmaceutical science but particularly drug delivery. Computational methods based on Hildebrand and... Read More about In Silico Screening for Solid Dispersions: The Trouble with Solubility Parameters and χFH.

Structural variations in hyperbranched polymers prepared via thermal polycondensation of lysine and histidine and their effects on DNA delivery (2018)
Journal Article
Alazzo, A., Lovato, T., Collins, H. M., Taresco, V., Stolnik, S., Soliman, M. E., …Alexander, C. (2018). Structural variations in hyperbranched polymers prepared via thermal polycondensation of lysine and histidine and their effects on DNA delivery. Journal of Interdisciplinary Nanomedicine, 3(2), https://doi.org/10.1002/jin2.36

The successful clinical translation of non-viral gene delivery systems has yet to be achieved due to the biological and technical obstacles to preparing a safe, potent and cost-effective vector. Hyper-branched polymers have emerged as promising candi... Read More about Structural variations in hyperbranched polymers prepared via thermal polycondensation of lysine and histidine and their effects on DNA delivery.

Time and cell-dependent effects of endocytosis inhibitors on the internalization of biomolecule markers and nanomaterials (2018)
Journal Article
Sasso, L., Purdie, L., Grabowska, A. M., Jones, A. T., & Alexander, C. (2018). Time and cell-dependent effects of endocytosis inhibitors on the internalization of biomolecule markers and nanomaterials. Journal of Interdisciplinary Nanomedicine, 3(2), https://doi.org/10.1002/jin2.39

Endocytosis is an essential function of cells, with key roles in the internalisation of nutrients, signal molecules and also drugs. Endocytic processes are therefore widely investigated in the context of drug delivery, and inhibitors of endocytic pat... Read More about Time and cell-dependent effects of endocytosis inhibitors on the internalization of biomolecule markers and nanomaterials.

Stimuli-responsive prodrug chemistries for drug delivery (2018)
Journal Article
Taresco, V., Alexander, C., Singh, N., & Pearce, A. K. (in press). Stimuli-responsive prodrug chemistries for drug delivery. Advanced Therapeutics, https://doi.org/10.1002/adtp.201800030

Research into advanced therapeutic materials is of growing importance worldwide, particularly in the disease areas of infection, neurodegeneration, and oncology. Advances have been made in treating these diverse pathologies but there still remain man... Read More about Stimuli-responsive prodrug chemistries for drug delivery.

Star-shaped poly(oligoethylene glycol) copolymer-based gels: thermo-responsive behaviour and bioapplicability for risedronate intranasal delivery (2018)
Journal Article
Soliman, M. E., Elmowafy, E., Casettari, L., & Alexander, C. (2018). Star-shaped poly(oligoethylene glycol) copolymer-based gels: thermo-responsive behaviour and bioapplicability for risedronate intranasal delivery. International Journal of Pharmaceutics, 543(1-2), 224-233. https://doi.org/10.1016/j.ijpharm.2018.03.053

The aim of this work was to obtain an intranasal delivery system with improved mechanical and mucoadhesive properties that could provide prolonged retention time for the delivery of risedronate (RS). For this, novel in situ forming gels comprising th... Read More about Star-shaped poly(oligoethylene glycol) copolymer-based gels: thermo-responsive behaviour and bioapplicability for risedronate intranasal delivery.