All Outputs (2)

Hypoxia-induced switch in SNAT2/SLC38A2 regulation generates endocrine resistance in breast cancer (2019)
Journal Article
Morotti, M., Bridges, E., Valli, A., Choudhry, H., Sheldon, H., Wigfield, S., Gray, N., Zois, C. E., Grimm, F., Jones, D., Teoh, E. J., Cheng, W.-C., Lord, S., Anastasiou, D., Haider, S., McIntyre, A., Goberdhan, D. C. I., Buffa, F., & Harris, A. L. (2019). Hypoxia-induced switch in SNAT2/SLC38A2 regulation generates endocrine resistance in breast cancer. Proceedings of the National Academy of Sciences, 116(25), 12452-12461. https://doi.org/10.1073/pnas.1818521116

Tumor hypoxia is associated with poor patient outcomes in estrogen receptor-α–positive (ERα+) breast cancer. Hypoxia is known to affect tumor growth by reprogramming metabolism and regulating amino acid (AA) uptake. Here, we show that the glutamine t... Read More about Hypoxia-induced switch in SNAT2/SLC38A2 regulation generates endocrine resistance in breast cancer.

Adaptation to HIF1a deletion in hypoxic cancer cells by upregulation of GLUT14 and creatine metabolism (2019)
Journal Article
Valli, A., Morotti, M., Zois, C. E., Albers, P. K., Soga, T., Feldinger, K., Fischer, R., Frejno, M., McIntyre, A., Bridges, E., Haider, S., Buffa, F. M., Baban, D., Rodriguez, M., Yanes, O., Whittington, H. J., Lake, H. A., Zervou, S., Lygate, C. A., Kessler, B. M., & Harris, A. L. (2019). Adaptation to HIF1a deletion in hypoxic cancer cells by upregulation of GLUT14 and creatine metabolism. Molecular Cancer Research, 17(7), 1531-1544. https://doi.org/10.1158/1541-7786.MCR-18-0315

© 2019 American Association for Cancer Research. Hypoxia-inducible factor 1a is a key regulator of the hypoxia response in normal and cancer tissues. It is well recognized to regulate glycolysis and is a target for therapy. However, how tumor cells a... Read More about Adaptation to HIF1a deletion in hypoxic cancer cells by upregulation of GLUT14 and creatine metabolism.