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All Outputs (91)

Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study (2016)
Journal Article
Inflammation Working Group of the CHARGE Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium, International Consortium for Blood Pressure, GERAD1 Consortium, CKDGen consortium, Autism Spectrum Disorder Working Group of the Psychiatric Genomics Consortium, …Alizadeh, B. Z. (2016). Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study. PLoS Medicine, 13(6), e1001976. https://doi.org/10.1371/journal.pmed.1001976

Background

C-reactive protein (CRP) is associated with immune, cardiometabolic, and psychiatric traits and diseases. Yet it is inconclusive whether these associations are causal.

Methods and Findings

We performed Mendelian randomization (MR)... Read More about Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study.

Familial Aggregation of Systemic Lupus Erythematosus and Coaggregation of Autoimmune Diseases in Affected Families (2015)
Journal Article
Kuo, C.-F., Grainge, M. J., Valdes, A. M., See, L.-C., Luo, S.-F., Yu, K.-H., …Doherty, M. (2015). Familial Aggregation of Systemic Lupus Erythematosus and Coaggregation of Autoimmune Diseases in Affected Families. JAMA Internal Medicine, 175(9), 1518-1526. https://doi.org/10.1001/jamainternmed.2015.3528

IMPORTANCE: Relatives of patients with systemic lupus erythematosus (SLE) appear to be at higher risk of SLE and other autoimmune diseases, but estimates of individual familial risks are largely unavailable or unreliable. Furthermore, relative contri... Read More about Familial Aggregation of Systemic Lupus Erythematosus and Coaggregation of Autoimmune Diseases in Affected Families.

Familial risk of Sjögren's syndrome and co-aggregation of autoimmune diseases in affected families: a nationwide population study (2015)
Journal Article
Kuo, C.-F., Grainge, M. J., Valdes, A. M., See, L.-C., Luo, S.-F., Yu, K.-H., …Doherty, M. (2015). Familial risk of Sjögren's syndrome and co-aggregation of autoimmune diseases in affected families: a nationwide population study. Arthritis and Rheumatology, 67(7), 1904-1912. https://doi.org/10.1002/art.39127

Objective: To investigate familial aggregation of Sjögren's syndrome (SS) and the relative risks (RRs) of other autoimmune disease in relatives of patients with SS.
Methods: We identified 23,658,577 beneficiaries enrolled in the Taiwan National Hea... Read More about Familial risk of Sjögren's syndrome and co-aggregation of autoimmune diseases in affected families: a nationwide population study.

An atlas of genetic influences on human blood metabolites (2014)
Journal Article
Shin, S.-Y., The Multiple Tissue Human Expression Resource (MuTHER) Consortium, Fauman, E. B., Petersen, A.-K., Krumsiek, J., Santos, R., …Soranzo, N. (2014). An atlas of genetic influences on human blood metabolites. Nature Genetics, 46(6), 543-550. https://doi.org/10.1038/ng.2982

Genome-wide association scans with high-throughput metabolic profiling provide unprecedented insights into how genetic variation influences metabolism and complex disease. Here we report the most comprehensive exploration of genetic loci influencing... Read More about An atlas of genetic influences on human blood metabolites.

Familial aggregation of gout and relative genetic and environmental contributions: a nationwide population study in Taiwan (2013)
Journal Article
Kuo, C., Grainge, M. J., See, L., Yu, K., Luo, S., Valdes, A. M., …Doherty, M. (2015). Familial aggregation of gout and relative genetic and environmental contributions: a nationwide population study in Taiwan. Annals of the Rheumatic Diseases, 74(2), 369-374. https://doi.org/10.1136/annrheumdis-2013-204067

© 2015, BMJ Publishing Group. All rights reserved. Objective: To examine familial aggregation of gout and to estimate the heritability and environmental contributions to gout susceptibility in the general population. Methods: Using data from the Nati... Read More about Familial aggregation of gout and relative genetic and environmental contributions: a nationwide population study in Taiwan.

A clinical assessment tool to improve the use of pain relieving treatments in knee osteoarthritis
Presentation / Conference Contribution
Akin-Akinyosoye, K., Frowd, N., Marshall, L., Stocks, J., Fernandes, G., Valdes, A., McWilliams, D., Zhang, W., Doherty, M., Ferguson, E., & Walsh, D. (2018, April). A clinical assessment tool to improve the use of pain relieving treatments in knee osteoarthritis. Presented at 2018 OARSI World Congress on Osteoarthritis : Promoting Clinical and Basic Research in Osteoarthritis, Liverpool, United Kingdom

Purpose: Approximately 1 in 4 individuals in the UK over the age of 55 experience knee pain (KP), predominantly due to osteoarthritis (OA). Following treatment targeted at the affected knee, pain relief is reported in only 60%–80% of individuals with... Read More about A clinical assessment tool to improve the use of pain relieving treatments in knee osteoarthritis.

Mediators of the predictive relationship between a self-report measure of central mechanisms and future knee pain outcomes in the knee pain in the community (KPIC) cohort
Presentation / Conference Contribution
Matthews, R., Akin-Akinyosoye, K., Frowd, N., Swaithes, L., Stocks, J., Sarmanova, A., Fernandes, G. S., Valdes, A., McWilliams, D. F., Zhang, W., Doherty, M., Ferguson, E., & Walsh, D. A. (2020, April). Mediators of the predictive relationship between a self-report measure of central mechanisms and future knee pain outcomes in the knee pain in the community (KPIC) cohort. Presented at OARSI 2020 World Congress, Vienna, Austria

Pain distant from the index site and sensitization in people with knee pain and low back pain
Presentation / Conference Contribution
Akin-Akinyosoye, K., Georgopoulos, V., Frowd, N., Swaithes, L., Stocks, J., Fernandes, G. S., Valdes, A., McWilliams, D., Zhang, W., Doherty, M., Ferguson, E., & Walsh, D. (2020, April). Pain distant from the index site and sensitization in people with knee pain and low back pain. Presented at OARSI 2020 World Congress, Vienna, Austria