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All Outputs (11)

Gut Microbiome Diversity and Composition Correlates With Time in the Therapeutic Range in Patients on Warfarin Treatment: A Pilot Study (2024)
Journal Article
Agosti, P., Kouraki, A., Dionisi, T., Addolorato, G., D’Innocenzo, L., Sorrentino, S., De Maio, F., De Candia, E., Blanco-Miguez, A., Bazzani, D., Bonadiman, A., Tonidandel, G., Bolzan, M., Gianniello, F., Passamonti, S. M., Abbattista, M., Valdes, A. M., Bucciarelli, P., Peyvandi, F., & Menni, C. (2024). Gut Microbiome Diversity and Composition Correlates With Time in the Therapeutic Range in Patients on Warfarin Treatment: A Pilot Study. Arteriosclerosis, Thrombosis, and Vascular Biology, https://doi.org/10.1161/ATVBAHA.124.321490

Supplementation with Citrus Low-Methoxy Pectin Reduces Levels of Inflammation and Anxiety in Healthy Volunteers: A Pilot Controlled Dietary Intervention Study (2024)
Journal Article
Vijay, A., Kelly, A., Miller, S., Marshall, M., Alonso, A., Kouraki, A., Probert, C., Simpson, E. J., & Valdes, A. M. (2024). Supplementation with Citrus Low-Methoxy Pectin Reduces Levels of Inflammation and Anxiety in Healthy Volunteers: A Pilot Controlled Dietary Intervention Study. Nutrients, 16(19), 3326. https://doi.org/10.3390/nu16193326

Background/Objective: Although low-methoxy (LM) pectin (polysaccharides extracted from citrus peels) can reduce inflammation by binding to and inhibiting the TLR-2 pathway in animal models and in vitro studies, the anti-inflammatory effects of LM pec... Read More about Supplementation with Citrus Low-Methoxy Pectin Reduces Levels of Inflammation and Anxiety in Healthy Volunteers: A Pilot Controlled Dietary Intervention Study.

Metagenomic changes in response to antibiotic treatment in severe orthopedic trauma patients (2024)
Journal Article
Kouraki, A., Zheng, A. S., Miller, S., Kelly, A., Ashraf, W., Bazzani, D., Bonadiman, A., Tonidandel, G., Bolzan, M., Vijay, A., Nightingale, J., Menni, C., Ollivere, B. J., & Valdes, A. M. (2024). Metagenomic changes in response to antibiotic treatment in severe orthopedic trauma patients. iScience, 27(9), Article 110783. https://doi.org/10.1016/j.isci.2024.110783

We investigated changes in microbiome composition and abundance of antimicrobial resistance (AMR) genes post-antibiotic treatment in severe trauma patients. Shotgun sequencing revealed beta diversity (Bray-Curtis) differences between 16 hospitalized... Read More about Metagenomic changes in response to antibiotic treatment in severe orthopedic trauma patients.

Vitamin A carotenoids, but not retinoids, mediate the impact of a healthy diet on gut microbial diversity (2024)
Journal Article
Valdes, A. M., Louca, P., Visconti, A., Asnicar, F., Bermingham, K., Nogal, A., Wong, K., Michelotti, G. A., Wolf, J., Segata, N., Spector, T. D., Berry, S. E., Falchi, M., & Menni, C. (2024). Vitamin A carotenoids, but not retinoids, mediate the impact of a healthy diet on gut microbial diversity. BMC Medicine, 22, Article 321. https://doi.org/10.1186/s12916-024-03543-4

: Background: Vitamin A is essential for physiological processes like vision and immunity. Vitamin A’s effect on gut microbiome composition, which affects absorption and metabolism of other vitamins, is still unknown. Here we examined the relationshi... Read More about Vitamin A carotenoids, but not retinoids, mediate the impact of a healthy diet on gut microbial diversity.

Association of serum biomarkers with radiographic knee osteoarthritis, knee pain and function in a young, male, trauma-exposed population – Findings from the ADVANCE study (2024)
Journal Article
O'Sullivan, O., Stocks, J., Schofield, S., Bilzon, J., Boos, C. J., Bull, A. M., Fear, N. T., Watt, F. E., Bennett, A. N., Kluzek, S., & Valdes, A. M. (2024). Association of serum biomarkers with radiographic knee osteoarthritis, knee pain and function in a young, male, trauma-exposed population – Findings from the ADVANCE study. Osteoarthritis and Cartilage, https://doi.org/10.1016/j.joca.2024.07.016

Objective: The ArmeD SerVices TrAuma RehabilitatioN OutComE (ADVANCE) study is investigating long-term combat-injury outcomes; this sub-study aims to understand the association of osteoarthritis (OA) biomarkers with knee radiographic OA (rOA), pain a... Read More about Association of serum biomarkers with radiographic knee osteoarthritis, knee pain and function in a young, male, trauma-exposed population – Findings from the ADVANCE study.

Modelling the role of enzymatic pathways in the metabolism of docosahexaenoic acid by monocytes and its association with osteoarthritic pain (2024)
Journal Article
Franks, S. J., Gowler, P. R., Dunster, J. L., Turnbull, J., Gohir, S. A., Kelly, A., Valdes, A. M., King, J. R., Barrett, D. A., Chapman, V., & Preston, S. (2024). Modelling the role of enzymatic pathways in the metabolism of docosahexaenoic acid by monocytes and its association with osteoarthritic pain. Mathematical Biosciences, 374, Article 109228. https://doi.org/10.1016/j.mbs.2024.109228

Chronic pain is a major cause of disability and suffering in osteoarthritis (OA) patients. Endogenous specialised pro-resolving molecules (SPMs) curtail pro-inflammatory responses. One of the SPM intermediate oxylipins, 17-hydroxydocasahexaenoic acid... Read More about Modelling the role of enzymatic pathways in the metabolism of docosahexaenoic acid by monocytes and its association with osteoarthritic pain.

Machine Learning Metabolomics Profiling of Dietary Interventions from a Six-Week Randomised Trial (2024)
Journal Article
Kouraki, A., Nogal, A., Nocun, W., Louca, P., Vijay, A., Wong, K., Michelotti, G. A., Menni, C., & Valdes, A. M. (2024). Machine Learning Metabolomics Profiling of Dietary Interventions from a Six-Week Randomised Trial. Metabolites, 14(6), Article 311. https://doi.org/10.3390/metabo14060311

Metabolomics can uncover physiological responses to prebiotic fibre and omega-3 fatty acid supplements with known health benefits and identify response-specific metabolites. We profiled 534 stool and 799 serum metabolites in 64 healthy adults followi... Read More about Machine Learning Metabolomics Profiling of Dietary Interventions from a Six-Week Randomised Trial.

Effects of a personalized nutrition program on cardiometabolic health: a randomized controlled trial (2024)
Journal Article
Bermingham, K. M., Linenberg, I., Polidori, L., Asnicar, F., Arrè, A., Wolf, J., Badri, F., Bernard, H., Capdevila, J., Bulsiewicz, W. J., Gardner, C. D., Ordovas, J. M., Davies, R., Hadjigeorgiou, G., Hall, W. L., Delahanty, L. M., Valdes, A. M., Segata, N., Spector, T. D., & Berry, S. E. (2024). Effects of a personalized nutrition program on cardiometabolic health: a randomized controlled trial. Nature Medicine, 30, 1888-1897. https://doi.org/10.1038/s41591-024-02951-6

Large variability exists in people’s responses to foods. However, the efficacy of personalized dietary advice for health remains understudied. We compared a personalized dietary program (PDP) versus general advice (control) on cardiometabolic health... Read More about Effects of a personalized nutrition program on cardiometabolic health: a randomized controlled trial.

Serum levels of hydroxylated metabolites of arachidonic acid cross-sectionally and longitudinally predict knee pain progression: an observational cohort study (2024)
Journal Article
Turnbull, J., Jha, R. R., Gowler, P. R., Ferrands-Bentley, R., Kim, D.-H., Barrett, D. A., Sarmanova, A., Fernandes, G. S., Doherty, M., Zhang, W., Walsh, D. A., Valdes, A. M., & Chapman, V. (2024). Serum levels of hydroxylated metabolites of arachidonic acid cross-sectionally and longitudinally predict knee pain progression: an observational cohort study. Osteoarthritis and Cartilage, 32(8), 990-1000. https://doi.org/10.1016/j.joca.2024.04.006

Objective: To examine associations between serum oxylipins, which regulate tissue repair and pain signalling, and knee pain/radiographic osteoarthritis (OA) at baseline and knee pain at 3 year follow-up.

Method: Baseline, and 3 year follow-up, kne... Read More about Serum levels of hydroxylated metabolites of arachidonic acid cross-sectionally and longitudinally predict knee pain progression: an observational cohort study.

Bacteriophages, gut bacteria, and microbial pathways interplay in cardiometabolic health (2024)
Journal Article
Kirk, D., Costeira, R., Visconti, A., Khan Mirzaei, M., Deng, L., Valdes, A. M., & Menni, C. (2024). Bacteriophages, gut bacteria, and microbial pathways interplay in cardiometabolic health. Cell Reports, 43(2), Article 113728. https://doi.org/10.1016/j.celrep.2024.113728

Cardiometabolic diseases are leading causes of mortality in Western countries. Well-established risk factors include host genetics, lifestyle, diet, and the gut microbiome. Moreover, gut bacterial communities and their activities can be altered by ba... Read More about Bacteriophages, gut bacteria, and microbial pathways interplay in cardiometabolic health.