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Postprandial glycaemic dips predict appetite and energy intake in healthy individuals (2021)
Journal Article
Wyatt, P., Berry, S. E., Finlayson, G., O’Driscoll, R., Hadjigeorgiou, G., Drew, D. A., …Valdes, A. M. (2021). Postprandial glycaemic dips predict appetite and energy intake in healthy individuals. Nature Metabolism, 3, 523–529. https://doi.org/10.1038/s42255-021-00383-x

Understanding how to modulate appetite in humans is key to developing successful weight loss interventions. Here, we showed that postprandial glucose dips 2–3 h after a meal are a better predictor of postprandial self-reported hunger and subsequent e... Read More about Postprandial glycaemic dips predict appetite and energy intake in healthy individuals.

β-blocker prescription is associated with lower cumulative risk of knee osteoarthritis and knee pain consultations in primary care: A propensity score-matched cohort study (2021)
Journal Article
Nakafero, G., Grainge, M. J., Valdes, A. M., Townsend, N., D. Mallen, C., Zhang, W., …Abhishek, A. (2021). β-blocker prescription is associated with lower cumulative risk of knee osteoarthritis and knee pain consultations in primary care: A propensity score-matched cohort study. Rheumatology, 60(12), 5686-5696. https://doi.org/10.1093/rheumatology/keab234

Objectives: To examine the association between β-blocker prescription and first primary-care consultation for knee OA, hip OA, knee pain and hip pain. Methods: Data source: Clinical Practice Research Datalink. Participants aged ≥40 years in receipt o... Read More about β-blocker prescription is associated with lower cumulative risk of knee osteoarthritis and knee pain consultations in primary care: A propensity score-matched cohort study.

Serum glucose, lactate dehydrogenase and hypertension are mediators of the 1 effect of body mass index on severity of COVID-19 (2021)
Journal Article
Yan, H., Vijay, A., Jiang, F., Zheng, N., Hu, Y., Ye, H., …Aithal, G. P. (2021). Serum glucose, lactate dehydrogenase and hypertension are mediators of the 1 effect of body mass index on severity of COVID-19. Endocrinology, Diabetes and Metabolism, 4(2), Article e00215. https://doi.org/10.1002/edm2.215

Background: COVID-19 has a broad clinical specturm. We investigated the role of serum markers measured on admission on severity as assessed at discharge and investigated those which relate to the effect of BMI on severity. Methods: Clinical and la... Read More about Serum glucose, lactate dehydrogenase and hypertension are mediators of the 1 effect of body mass index on severity of COVID-19.

High intake of vegetables is linked to lower white blood cell profile and the effect is mediated by the gut microbiome (2021)
Journal Article
Menni, C., Louca, P., Berry, S. E., Vijay, A., Astbury, S., Leeming, E. R., …Valdes, A. M. (2021). High intake of vegetables is linked to lower white blood cell profile and the effect is mediated by the gut microbiome. BMC Medicine, 19, 1-10. https://doi.org/10.1186/s12916-021-01913-w

Background: Chronic inflammation, which can be modulated by diet, is linked to high white blood cell counts and correlates with higher cardiometabolic risk and risk of more severe infections, as in the case of COVID-19. Methods: Here, we assessed th... Read More about High intake of vegetables is linked to lower white blood cell profile and the effect is mediated by the gut microbiome.

Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals (2021)
Journal Article
Asnicar, F., Berry, S. E., Valdes, A. M., Nguyen, L. H., Piccinno, G., Drew, D. A., …Segata, N. (2021). Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals. Nature Medicine, 27, 321–332. https://doi.org/10.1038/s41591-020-01183-8

The gut microbiome is shaped by diet and influences host metabolism; however, these links are complex and can be unique to each individual. We performed deep metagenomic sequencing of 1,203 gut microbiomes from 1,098 individuals enrolled in the Perso... Read More about Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals.

Role of drugs used for chronic disease management on susceptibility and severity of COVID-19: A large case-control study (2020)
Journal Article
Yan, H., Valdes, A. M., Vijay, A., Wang, S., Liang, L., Yang, S., …Aithal, G. P. (2020). Role of drugs used for chronic disease management on susceptibility and severity of COVID-19: A large case-control study. Clinical Pharmacology and Therapeutics, 108(6), 1185-1194. https://doi.org/10.1002/cpt.2047

The study aimed to investigate whether specific medications used in the treatment chronic diseases affected either the development and/ or severity of COVID-19 in a cohort of 610 COVID-19 cases and 48,667 population-based controls from Zheijang, Chin... Read More about Role of drugs used for chronic disease management on susceptibility and severity of COVID-19: A large case-control study.

East Midlands knee pain multiple randomised controlled trial cohort study: cohort establishment and feasibility study protocol (2020)
Journal Article
Hall, M., Fuller, A., Nomikos, P. A., Millar, B., Ogollah, R., Valdes, A., …Abhishek, A. (2020). East Midlands knee pain multiple randomised controlled trial cohort study: cohort establishment and feasibility study protocol. BMJ Open, 10(9), Article e037760. https://doi.org/10.1136/bmjopen-2020-037760

© 2020 BMJ Open Introduction Knee pain due to osteoarthritis (OA) is a common cause of disability. The UK National Institute for Health and Care Excellence OA guidelines recommend education, exercise and weight loss advice (if overweight) as core int... Read More about East Midlands knee pain multiple randomised controlled trial cohort study: cohort establishment and feasibility study protocol.

The East Midlands Knee Pain Multiple Randomised Controlled Trial Cohort Study: Cohort Establishment and Feasibility study protocol (2020)
Journal Article
Hall, M. C., Fuller, A., Nomikos, P. A., Millar, B., Ogollah, R., Valdes, A., …Abhishek, A. (2020). The East Midlands Knee Pain Multiple Randomised Controlled Trial Cohort Study: Cohort Establishment and Feasibility study protocol. BMJ Open, 10(9), Article e037760

Introduction: Knee pain and osteoarthritis (OA) are a common cause of disability. The UK National Institute of Health and Care Excellence (NICE) OA guidelines recommend education, exercise and weight-loss advice (if overweight) as core interventions... Read More about The East Midlands Knee Pain Multiple Randomised Controlled Trial Cohort Study: Cohort Establishment and Feasibility study protocol.

Serum metabolites reflecting gut microbiome alpha diversity predict type 2 diabetes (2020)
Journal Article
Menni, C., Zhu, J., Le Roy, C. I., Mompeo, O., Young, K., Rebholz, C. M., …Valdes, A. M. (2020). Serum metabolites reflecting gut microbiome alpha diversity predict type 2 diabetes. Gut Microbes, 11(6), 1632-1642. https://doi.org/10.1080/19490976.2020.1778261

Type 2 diabetes (T2D) is associated with reduced gut microbiome diversity, although the cause is unclear. Metabolites generated by gut microbes also appear to be causative factors in T2D. We therefore searched for serum metabolites predictive of gut... Read More about Serum metabolites reflecting gut microbiome alpha diversity predict type 2 diabetes.

Human postprandial responses to food and potential for precision nutrition (2020)
Journal Article
Berry, S. E., Valdes, A. M., Drew, D. A., Asnicar, F., Mazidi, M., Wolf, J., Capdevila, J., Hadjigeorgiou, G., Davies, R., Al Khatib, H., Bonnett, C., Ganesh, S., Bakker, E., Hart, D., Mangino, M., Merino, J., Linenberg, I., Wyatt, P., Ordovas, J. M., Gardner, C. D., …Spector, T. D. (2020). Human postprandial responses to food and potential for precision nutrition. Nature Medicine, 26, 964-973. https://doi.org/10.1038/s41591-020-0934-0

Metabolic responses to food influence risk of cardiometabolic disease, but large-scale high-resolution studies are lacking. We recruited n = 1,002 twins and unrelated healthy adults in the United Kingdom to the PREDICT 1 study and assessed postprandi... Read More about Human postprandial responses to food and potential for precision nutrition.

Real-time tracking of self-reported symptoms to predict potential COVID-19 (2020)
Journal Article
Menni, C., Valdes, A. M., Freidin, M. B., Sudre, C. H., Nguyen, L. H., Drew, D. A., …Spector, T. D. (2020). Real-time tracking of self-reported symptoms to predict potential COVID-19. Nature Medicine, 26, 1037-1040. https://doi.org/10.1038/s41591-020-0916-2

A total of 2,618,862 participants reported their potential symptoms of COVID-19 on a smartphone-based app. Among the 18,401 who had undergone a SARS-CoV-2 test, the proportion of participants who reported loss of smell and taste was higher in those w... Read More about Real-time tracking of self-reported symptoms to predict potential COVID-19.

The Evaluation and Use of a Food Frequency Questionnaire Among the Population in Trivandrum, South Kerala, India (2020)
Journal Article
Vijay, A., Mohan, L., Taylor, M. A., Grove, J. I., Valdes, A. M., Aithal, G. P., & Shenoy, K. T. (2020). The Evaluation and Use of a Food Frequency Questionnaire Among the Population in Trivandrum, South Kerala, India. Nutrients, 12(2), Article 383. https://doi.org/10.3390/nu12020383

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Dietary record tools such as food frequency questionnaire (FFQ) and food diaries (FD) are the most commonly used choices for assessing dietary intakes in most large-scale epidemiological studi... Read More about The Evaluation and Use of a Food Frequency Questionnaire Among the Population in Trivandrum, South Kerala, India.

Baseline self-report ‘central mechanisms’ trait predicts persistent knee pain in the Knee Pain in the Community (KPIC) cohort (2019)
Journal Article
Akin-Akinyosoye, K., Sarmanova, A., Fernandes, G., Frowd, N., Swaithes, L., Stocks, J., …Walsh, D. A. (2020). Baseline self-report ‘central mechanisms’ trait predicts persistent knee pain in the Knee Pain in the Community (KPIC) cohort. Osteoarthritis and Cartilage, 28(2), 173-181. https://doi.org/10.1016/j.joca.2019.11.004

Objectives We investigated whether baseline scores for a self-report trait linked to central mechanisms predict 1 year pain outcomes in the Knee Pain in the Community cohort. Method 1471 participants reported knee pain at baseline and respon... Read More about Baseline self-report ‘central mechanisms’ trait predicts persistent knee pain in the Knee Pain in the Community (KPIC) cohort.

Lower gut microbiome diversity and higher abundance of proinflammatory genus Collinsella are associated with biopsy-proven non-alcoholic steatohepatitis (2019)
Journal Article
Astbury, S., Atallah, E., Vijay, A., Aithal, G., Grove, J., & Valdes, A. (2020). Lower gut microbiome diversity and higher abundance of proinflammatory genus Collinsella are associated with biopsy-proven non-alcoholic steatohepatitis. Gut Microbes, 11(3), 569-580. https://doi.org/10.1080/19490976.2019.1681861

There is increasing evidence for the role of gut microbial composition in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Non-alcoholic steatohepatitis (NASH) is the most serious form of NAFLD where inflammation causes liver damage tha... Read More about Lower gut microbiome diversity and higher abundance of proinflammatory genus Collinsella are associated with biopsy-proven non-alcoholic steatohepatitis.

Do β-adrenoreceptor blocking drugs associate with reduced risk of symptomatic osteoarthritis and total joint replacement in the general population?: A primary-care based prospective cohort study using the Clinical Practice Research Datalink (2019)
Journal Article
Nakafero, G., Grainge, M., Valdes, A., Townsend, N., Mallen, C., Zhang, W., …Abhishek, A. (2019). Do β-adrenoreceptor blocking drugs associate with reduced risk of symptomatic osteoarthritis and total joint replacement in the general population?: A primary-care based prospective cohort study using the Clinical Practice Research Datalink. BMJ Open, 9(8), Article e032050. https://doi.org/10.1136/bmjopen-2019-032050

© Author(s) (or their employer(s)) 2019. Introduction: To investigate if β-adrenoreceptor blocking drug (β-blocker) prescription reduces the risk of knee or hip osteoarthritis, total joint replacement and analgesic prescription. Setting: Primary care... Read More about Do β-adrenoreceptor blocking drugs associate with reduced risk of symptomatic osteoarthritis and total joint replacement in the general population?: A primary-care based prospective cohort study using the Clinical Practice Research Datalink.

Circulating levels of the anti-oxidant indoleproprionic acid are associated with higher gut microbiome diversity (2019)
Journal Article
Menni, C., Hernandez, M. M., Vital, M., Mohney, R. P., Spector, T. D., & Valdes, A. M. (2019). Circulating levels of the anti-oxidant indoleproprionic acid are associated with higher gut microbiome diversity. Gut Microbes, 10(6), 688-695. https://doi.org/10.1080/19490976.2019.1586038

The gut microbiome has recently emerged as an important regulator of insulin resistance and abdominal obesity. The tryptophan metabolite generated by the gut microbiome, indoleproprionic acid (IPA) has been shown to predict the onset of type 2 diabet... Read More about Circulating levels of the anti-oxidant indoleproprionic acid are associated with higher gut microbiome diversity.

Omega-6 oxylipins generated by soluble epoxide hydrolase are associated with knee osteoarthritis (2018)
Journal Article
Valdes, A. M., Ravipati, S., Pousinis, P., Menni, C., Mangino, M., Abhishek, A., …Doherty, M. (in press). Omega-6 oxylipins generated by soluble epoxide hydrolase are associated with knee osteoarthritis. Journal of Lipid Research, 59(7), Article jlr.P085118. https://doi.org/10.1194/jlr.P085118

Omega-6 fatty acids are important inflammatory mediators increased in joints with osteoarthritis (OA) joints. To investigate the relationship between omega-6 fatty acids and knee OA 22 omega-6 lipids (arachidonic acid, linoleic acid and 20 oxylipins)... Read More about Omega-6 oxylipins generated by soluble epoxide hydrolase are associated with knee osteoarthritis.

The fecal metabolome as a functional readout of the gut microbiome (2018)
Journal Article
Zierer, J., Jackson, M. A., Kastenmüller, G., Mangino, M., Long, T., Telenti, A., …Menni, C. (2018). The fecal metabolome as a functional readout of the gut microbiome. Nature Genetics, 50(6), 790-795. https://doi.org/10.1038/s41588-018-0135-7

© 2018 The Author(s). The human gut microbiome plays a key role in human health 1 , but 16S characterization lacks quantitative functional annotation 2 . The fecal metabolome provides a functional readout of microbial activity and can be used as an... Read More about The fecal metabolome as a functional readout of the gut microbiome.

Glycosylation profile of immunoglobulin G is cross-sectionally associated with cardiovascular disease risk score and subclinical atherosclerosis in two independent cohorts (2018)
Journal Article
Menni, C., Gudelj, I., Macdonald-Dunlop, E., Mangino, M., Zierer, J., Bešić, E., …Valdes, A. (2018). Glycosylation profile of immunoglobulin G is cross-sectionally associated with cardiovascular disease risk score and subclinical atherosclerosis in two independent cohorts. Circulation Research, 122(11), 1555-1564. https://doi.org/10.1161/CIRCRESAHA.117.312174

Rationale: One measure of protein glycosylation (GlycA) has been reported to predict higher cardiovascular risk by reflecting inflammatory pathways. Objective: The main objective of this study is to assess the role of a comprehensive panel of Ig... Read More about Glycosylation profile of immunoglobulin G is cross-sectionally associated with cardiovascular disease risk score and subclinical atherosclerosis in two independent cohorts.