Hydrogel-Based Pre-Clinical Evaluation of Repurposed FDA-Approved Drugs for AML

James, Jenna R.; Curd, Johnathan; Ashworth, Jennifer C.; Abuhantash, Mays; Grundy, Martin; Seedhouse, Claire H.; Arkill, Kenton P.; Wright, Amanda J.; Merry, Catherine L. R.; Thompson, Alexander

doi:10.3390/ijms24044235

All Outputs (3)

The Mitotic Chromosome Periphery: A Fluid Coat That Mediates Chromosome Mechanics (2024)
Preprint / Working Paper
Mendonca, T., Urban, R., Lucken, K., Coney, G., Tassieri, M., Kad, N. M., Wright, A. J., & Booth, D. G. (2024). The Mitotic Chromosome Periphery: A Fluid Coat That Mediates Chromosome Mechanics

OptoRheo: Simultaneous in situ micro-mechanical sensing and imaging of live 3D biological systems (2023)
Journal Article
Mendonca, T., Lis-Slimak, K., Matheson, A. B., Smith, M. G., Anane-Adjei, A. B., Ashworth, J. C., Cavanagh, R., Paterson, L., Dalgarno, P. A., Alexander, C., Tassieri, M., Merry, C. L. R., & Wright, A. J. (2023). OptoRheo: Simultaneous in situ micro-mechanical sensing and imaging of live 3D biological systems. Communications Biology, 6, Article 463. https://doi.org/10.1038/s42003-023-04780-8

Biomechanical cues from the extracellular matrix (ECM) are essential for directing many cellular processes, from normal development and repair, to disease progression. To better understand cell-matrix interactions, we have developed a new instrument... Read More about OptoRheo: Simultaneous in situ micro-mechanical sensing and imaging of live 3D biological systems.

Hydrogel-Based Pre-Clinical Evaluation of Repurposed FDA-Approved Drugs for AML (2023)
Journal Article
James, J. R., Curd, J., Ashworth, J. C., Abuhantash, M., Grundy, M., Seedhouse, C. H., Arkill, K. P., Wright, A. J., Merry, C. L. R., & Thompson, A. (2023). Hydrogel-Based Pre-Clinical Evaluation of Repurposed FDA-Approved Drugs for AML. International Journal of Molecular Sciences, 24(4), Article 4235. https://doi.org/10.3390/ijms24044235

In vivo models of acute myeloid leukemia (AML) are low throughput, and standard liquid culture models fail to recapitulate the mechanical and biochemical properties of the extracellular matrix-rich protective bone marrow niche that contributes to dru... Read More about Hydrogel-Based Pre-Clinical Evaluation of Repurposed FDA-Approved Drugs for AML.