Structural dynamics of DNA unwinding by a replicative helicase
(2025)
Journal Article
Shahid, T., Danazumi, A. U., Tehseen, M., Alhudhali, L., Clark, A. R., Savva, C. G., Hamdan, S. M., & De Biasio, A. (2025). Structural dynamics of DNA unwinding by a replicative helicase. Nature, 641(8061), 240-249. https://doi.org/10.1038/s41586-025-08766-w
Hexameric helicases are nucleotide-driven molecular machines that unwind DNA to initiate replication across all domains of life. Despite decades of intensive study, several critical aspects of their function remain unresolved1: the site and mechanism... Read More about Structural dynamics of DNA unwinding by a replicative helicase.